ID A0A1S3WS19_ERIEU Unreviewed; 461 AA.
AC A0A1S3WS19;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B {ECO:0000256|ARBA:ARBA00031786};
DE EC=2.1.1.361 {ECO:0000256|ARBA:ARBA00012187};
DE EC=2.1.1.362 {ECO:0000256|ARBA:ARBA00012188};
DE AltName: Full=[histone H4]-lysine20 N-methyltransferase KMT5B {ECO:0000256|ARBA:ARBA00031835};
GN Name=KMT5C {ECO:0000313|RefSeq:XP_016048964.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016048964.1};
RN [1] {ECO:0000313|RefSeq:XP_016048964.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61992, Rhea:RHEA-
CC COMP:15556, Rhea:RHEA-COMP:15998, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; Evidence={ECO:0000256|ARBA:ARBA00001543};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61993;
CC Evidence={ECO:0000256|ARBA:ARBA00001543};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine
CC = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60348, Rhea:RHEA-COMP:15555, Rhea:RHEA-
CC COMP:15556, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61929, ChEBI:CHEBI:61976; EC=2.1.1.362;
CC Evidence={ECO:0000256|ARBA:ARBA00000167};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60349;
CC Evidence={ECO:0000256|ARBA:ARBA00000167};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016048964.1; XM_016193478.1.
DR AlphaFoldDB; A0A1S3WS19; -.
DR GeneID; 103124485; -.
DR CTD; 84787; -.
DR OrthoDB; 5396777at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140944; F:histone H4K20 monomethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0140941; F:histone H4K20me methyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR039977; Suv4-20/Set9.
DR InterPro; IPR025790; Suv4-20_animal.
DR PANTHER; PTHR12977:SF11; HISTONE-LYSINE N-METHYLTRANSFERASE KMT5C; 1.
DR PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 107..221
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 299..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 49098 MW; D78069A5C857B7EC CRC64;
MGPDRVDRVT ARELCENDDL ATSLVLDPYL GFRTHKMNVS PVPPLRRQHH LRSALEAFLR
QRDLEAAYRA LTLGGWMAHY FQSRGPRQEA ALKTHIYRYL RAFLPESGFA ILPCTRYSME
TNGAKIVSTR AWKKNEKLEL LVGCIAELRD DDEGLLRAGE NDFSIMYSTR KRSAQLWLGP
AAFINHDCKP NCKFVPADGN AACVKALRDI EPGDEVTCFY GDGFFGEKNE HCECHTCERA
TGQVRAPGDQ AAAAAGPAGL QGLHPPVLAA ARPLLRPFLR CLPAAPPALW RRPPPLAPVA
PPAPSPRAAL RAPQEAPAAP APQGSRSAPA APSSPDLPAP LGRLRPPMLP ACGGAGGAGP
GTPPTLGPPT GLALGPALRP ALRGAGGPEP SGPHRACSTH PDGAPRPRPT AQAGPRLRPL
LPTQASATGG QPRLHRPGRP WRGPMTQVWG GRLGLPGALG L
//
