ID A0A1U7RIN9_ALLSI Unreviewed; 557 AA.
AC A0A1U7RIN9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=L-dopachrome tautomerase {ECO:0000256|ARBA:ARBA00039823};
DE EC=5.3.3.12 {ECO:0000256|ARBA:ARBA00038932};
DE AltName: Full=L-dopachrome Delta-isomerase {ECO:0000256|ARBA:ARBA00042019};
DE AltName: Full=Tyrosinase-related protein 2 {ECO:0000256|ARBA:ARBA00041443};
GN Name=DCT {ECO:0000313|RefSeq:XP_006020746.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006020746.1};
RN [1] {ECO:0000313|RefSeq:XP_006020746.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate;
CC Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509;
CC EC=5.3.3.12; Evidence={ECO:0000256|ARBA:ARBA00036823};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Pigment biosynthesis; melanin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037907}.
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR RefSeq; XP_006020746.1; XM_006020684.1.
DR STRING; 38654.A0A1U7RIN9; -.
DR GeneID; 102378044; -.
DR KEGG; asn:102378044; -.
DR CTD; 1638; -.
DR eggNOG; ENOG502QRNA; Eukaryota.
DR InParanoid; A0A1U7RIN9; -.
DR OrthoDB; 70287at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 2.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF4; L-DOPACHROME TAUTOMERASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 2.
DR PROSITE; PS00497; TYROSINASE_1; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..557
FT /note="L-dopachrome tautomerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010550123"
FT TRANSMEM 506..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 217..234
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
SQ SEQUENCE 557 AA; 63475 MW; 3E4BF9FF38D0DE81 CRC64;
MTFLQQWAKW FRWMVLSYLS CCYPPQAEAQ FPRACMTVEA LRAKRCCPAL GLEPSNMCGS
RQGRGSCTEV QADARPWSGP YTLRNVDDRE RWPLKFFNQS CQCTGNFAGY NCGNCKFGWT
GSNCDEKKPL VVRKNIHSMT AEERDQFLDA LDRAKNTIHP DYVIATQHWL SLLGSNGTEP
QVANCSIYNY FVWLHYYSVR DTLLGPGRPF TAIDFSHQGP AFVTWHRYHL LLLERDLQQL
TGNESFALPY WNFATGRNVC DVCTDQLFGA SRPDDPSLIS QNSRFSRWEV VCNSLDDYNR
LVTLCNGTNE GLLRRNPRGR LNEQLPTMED IRNCLSLQEF DSPPFFRNSN FSFRXALEGF
ENPDGTFVSP VMSLHNLVHS FLNGTSALPH AAANDPIFVV MNNSVVGNLT TILLHLKEQV
TTLLPNVLIS ILHSFTDAVF DEWMKRFNPS DSVWPEELAP IGHNRLYNMV PFFPPVTNDQ
LFLTAEQLGY TYAIELPEAF EETHAWAVMV GSILGGALIA LIVLILLLAL FQHRRQRKGF
EPLMNVSFNR KKYTEEG
//
