ID A0A1U7XVU0_NICSY Unreviewed; 692 AA.
AC A0A1U7XVU0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=LOC104238425 {ECO:0000313|RefSeq:XP_009791074.1};
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096 {ECO:0000313|Proteomes:UP000189701, ECO:0000313|RefSeq:XP_009791074.1};
RN [1] {ECO:0000313|Proteomes:UP000189701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23773524; DOI=10.1186/gb-2013-14-6-r60;
RA Sierro N., Battey J.N., Ouadi S., Bovet L., Goepfert S., Bakaher N.,
RA Peitsch M.C., Ivanov N.V.;
RT "Reference genomes and transcriptomes of Nicotiana sylvestris and Nicotiana
RT tomentosiformis.";
RL Genome Biol. 14:R60.1-R60.17(2013).
RN [2] {ECO:0000313|RefSeq:XP_009791074.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_009791074.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR RefSeq; XP_009791074.1; XM_009792772.1.
DR AlphaFoldDB; A0A1U7XVU0; -.
DR STRING; 4096.A0A1U7XVU0; -.
DR GeneID; 104238425; -.
DR KEGG; nsy:104238425; -.
DR eggNOG; KOG0922; Eukaryota.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17980; DEXHc_DHX35; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|RefSeq:XP_009791074.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189701}.
FT DOMAIN 58..223
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 258..433
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 692 AA; 77466 MW; 31DBD40C38A51EF9 CRC64;
MSQFWKPGTE RPRLVDDEEG GVLLYPTSSS SSSSGFGYGS LEKQRQRLPV YKYRTDILYL
VETHATTIIV GETGSGKTTQ IPQYLKEAGW AEGGRMIACT QPRRLAVQAV ASRVAEEMDV
KLGEEVGYTI RFEDITNEEL TRVKFLTDGV LLREMMDDPL LSKYSVIMVD EAHERSLSTD
ILLGLLKKIQ RRRPELRIII SSATIEAKSM AAFFNTSKKR REQEQGPTRE PAILSVEGRG
FNVEIFYVDD PVSDYVRAVI STVLSIHDQE RTGDILVFLT GQDDIDAAIQ LLTEEAQSSG
KQGLVAVPLY SGLPRADQDL VFSPTPRGKR KVIFSTNIAE TSLTLEGIVY VVDSGFSKQR
FYNPISDIEN LVVAPISKAS ARQRAGRAGR VRPGKCFRLY TEDYFASEMS IVGIPEIQRS
NLVSCVIQLK ALGIDNILGF DWPASPSPEA MIRALEILYS LGVLDDDAKL TSPTGFQVAE
FPLDPLISKM ILASCELGCT EEIITIAATL SIQSIWIPVR GVQKELDEAK LRFAAAEGDH
VTFLNVYKGF IQSNKSSKWC HKNFVNYHAM RKVIEVREQL KRITQRLGIG LKSCEGDMQA
VRKAITAGFF ANASRLEPFS HNGMYKTVRT SQEVYIHPSS VLFRVNPKWI VYHSLVSTDR
QYMRNVITVD PSWLTEAAPH FYQKQMHSSI PQ
//
