ID A0A1U8GDT9_CAPAN Unreviewed; 1474 AA.
AC A0A1U8GDT9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=T459_00207 {ECO:0000313|EMBL:PHT92325.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT92325.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT92325.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT92325.1}.
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DR EMBL; AYRZ02000001; PHT92325.1; -; Genomic_DNA.
DR RefSeq; XP_016566219.1; XM_016710733.1.
DR EnsemblPlants; PHT92325; PHT92325; T459_00207.
DR Gramene; PHT92325; PHT92325; T459_00207.
DR OMA; DRFCTEY; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000222542; Chromosome 1.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223:SF263; ABC-TYPE XENOBIOTIC TRANSPORTER; 1.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1032..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..580
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 617..838
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 911..1187
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1224..1458
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 843..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 164151 MW; 8A1ACBA0EF81D306 CRC64;
MDLWPVFCGE DDCSQKAGES CSSTFPDPSS CTSRILVISA NILLLIILVF LFSAKFSSRK
SVSSSEFQGN SILSTFSYIF NGTLALAYLS LGTWKVLHIV VSGHTVLPLL QWLVPMSQGL
MLLMLSLLSI YKKQYTSSPG KWCLFMASLL ESFLCISSVW QVIVENTVYT KSVLDVLPLL
GVILMIISAS KGQEKLSTCE PLLGEKANAC GQAESKDNTT PFAKAGFFSR MSFCWLNDLL
KKGKEKTLND EDIPALRMED QAGTLYSLFK EQVNRSKQKT SSPRPSVFSA IVFCQWKAIV
VSGFFALIKT VTVSIGPLFL YAFIEVAKGK GAFKYEGYVL AGAILIAKCI ESLAERQWFF
RTRLIGLQVK SLLTAAIYDK QLHLSNVAKN THSPGEIINY ATVDTFKVGE FPYWFHQIWT
TCIQICIALV IMYYAVGLAT VPALLLVVAS VLGNSPVAKY QHKYLTELMV AQDRMLMAIT
ESLTSMKVLK LYAWEKHFKN AIVKLREEEY RWLSAVQMQK GYYLVLFWST PIIVSAVTFW
SCYLLKVPLN TTNVFTFLAT LRIVQEPVRS VPDILGVFIE AKVSLSRIVE FLEAPELQNR
RIEQKYRRKE LEPSIIIKSN GISWVASSPN PAVKSVNLHV KQGQKLAICG EVGSGKSTLL
AAILGEVPYV DGLVQVHGTV SYVSQNAWIQ TGTIRDNILF GSTMDQIKYQ EVLERCSLVK
DLEMLPFGDQ TIIGERGVNL SGGQKQRVQL ARALYQDSDI YLLDDPFSAV DAHTSTCLFN
DYVMGALSGK IVLLVTHQVD FLPTFDAILL MSKGNIMQSA SFDQLLLSSE EFRNLIHAHG
EATKSESNRG CAPQGRTKRS EENIHQLSAE EQLITLIGEQ LIKQEERESG YTGIKPYKHY
LVQSNGLFHL LLAIFSHLLF MVGQLGQNLL LAADLQSSRT TMFNLILVYS SIGFGMSLTL
FIRSYAVIDL GLKSSKSIFT KLLTSIFRAP MSFYDSTPLG RILSRLSSDL SVLDLDMSFR
FSQTLSSTFT TYFSLGLLAA LTWPILIVII PTIYMTVILQ RFYFASAKEL MRIDGTTKSS
VASNLAEAIA GAMTIRAFEE EDRFCTEYLQ LVDSNAVAFF HSFSATEWLI QRLEILCAVV
LSSSALAMVL LPFEASDSGY IGMALSYALS LNVFLVSSVQ NQCMLENSII SVERLEQYMH
IPSERPEIIQ GNRPDPSWPS TGKVEIVDLK VRYQPNVPLV LQGISCIIEG GYKVGIVGRT
GSGKTTLISA LFRLVEPTEG MIIIDGLNIS TIGNHDLRSS LSIIPQDPTL FSGTVRYNLD
PLSEHTDQEI WEVLGKCQLR DAVQQKEGRL DSSVAQDGSN WSMGQRQLFC LGRALLKRRK
ILVLDEATAS IDNATDSIIQ KTIRTEFEDC TVITVAHRIP TVMDCTMVLA ISDGKLVEYD
KPMKLMNKES SLFGQLVDEY WSRSQNADIQ INSI
//
