ID A0A1U8J8B7_GOSHI Unreviewed; 914 AA.
AC A0A1U8J8B7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=LOC107904655 {ECO:0000313|RefSeq:XP_016686590.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016686590.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016686590.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016686590.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR RefSeq; XP_016686590.1; XM_016831101.1.
DR AlphaFoldDB; A0A1U8J8B7; -.
DR GeneID; 107904655; -.
DR KEGG; ghi:107904655; -.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd00048; DSRM_SF; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF229; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|RefSeq:XP_016686590.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 26..193
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 282..456
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 914 AA; 102232 MW; 4024CA840CE7043D CRC64;
MESPEGQKML EFRRSLPAYK ERDALLNAIS QNQVVVVSGE TGCGKTTQLP QYILESEIEA
ARGASCSIIC TQPRRISAMA VSERVAAERG EKLGESVGYK VRLEGMKGRD TRLLFCTTGI
LLRRLLVDRD LRGVSHVIVD EIHERGMNED FLLIVLKDLL PRRPELRLIL MSATLNAELF
SSYYGGAPTI HIPGFTYPVR AHFLENILEM SGYRLTPYNQ IDDYGQEKMW KMQKQAQSFK
KRKSQLTSAV EDVLEDADFR GCSLRTRESL SCWNPDSIGF NLIEHVLCHI VRKERPGAVL
VFMTGWDDIN SLKGQLQAHP LLGDPSKVLL LACHGSMPSS EQRLIFEKPE DGVRKIVLAT
NMAETSITIN DVVFVVDCGK AKETSYDALN NTPCLLPSWI SKAAARQRRG RAGRVQPGEC
YHLYPKCVYD TFADYQLPEL LRTPLQSLCL QIKSLELGGI TEFLSRALQP PELLSVQNAV
EYLKITGASD DNENLTVLGC NLSMLPVEPK LGKMLILGAI FNCLDPIMTV VAGLSVRDPF
LMPFDKKDLA ETAKAQFAGQ EYSDHIAVIR AYEGWKEAER EQSGYEYCWK NFLSAQTLKA
IHSLRKQFFY LLKDAGLVDQ NVENCNKWSH DEHLVRAVIC AGLFPGICSV VNKEKSIAMK
TMEDGQVLLH SNSVNAEVPK VPYPWLVFNE KVKVNAVFLR DSTGVSDSIL LLFGGNISRG
GLDGHLKMLG GYLEFFMKPA LAVMYLSVKR ELEELIQRKL LDPTLDMHSS NELLSAVRLL
VSEDRCEGRF VFGRQVTLSS KKTATVKTPG KSEADNSKNH LQTVLTRAGH GPPTYKTKQL
KNNQFRSTVI FNGLDFVGQP CSSKKLAEKD AAAQALLWLR GEDHSTSRDI DHASLLLKKS
KSRRKTSVSD AKWS
//
