ID A0A1V4JKF4_PATFA Unreviewed; 1429 AA.
AC A0A1V4JKF4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=YTHDC2 {ECO:0000313|EMBL:OPJ72640.1};
GN ORFNames=AV530_008947 {ECO:0000313|EMBL:OPJ72640.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ72640.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ72640.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ72640.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ72640.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ72640.1}.
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DR EMBL; LSYS01006904; OPJ72640.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4JKF4; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OPJ72640.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 37..105
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 202..368
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 505..537
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 607..783
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1287..1417
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 159946 MW; FCFD616A4925ECC5 CRC64;
MSRPNSVFSP QPGAGSSAPA ASAGPAAGRG RSKGLKDIRV DEEVEIAVNL ALDRFRSGEE
KEMEFPSSFT STERAFVHRL CQSLGLISKS KGKGANRYLT VRKKDGSELT HAVMICCLAP
SIKHAIRSFI QRFPVTNKER TELLPKTERG NACAVESENR EVKKTSGRLN SGIPQVPVKR
GESEFDSFRQ SLPVFEKQEE IVKTIKENKV VLIVGETGSG KTTQIPQFVL DDCSKNGTPC
RMFCTQPRRL AAIAVAERVA AERREKIGQT IGYQIRLESR VSPKTLLTFC TNGILLRTLM
AGDSTLSTVT HVIVDEVHER DRFSDFLLIK LRDVLQKQPN LKLIISSAAL DADLFIRYFG
SCPVIHIQGR PFEVKEMFLE DILRSTGYTN KEMVKYKKEK QREEKQQSTL TEWCSAQESN
SKLESQRQRS VPSAIEEYNL LDDGGDTVFT QLTEKDANCL EPWLIKEMDS CLSDIWLHKD
VDSFAQVFHL ILTENVSVDY RHSETSATAL MIASGRGFLS QVEQLISMGA NIHLKSSNGW
MALDWAKCFG QTEVVDLLES YSASVEFGNA DESSLVQSTS SDLSAEDREL LKAYHHSFDS
EKVDLDLIMH LLYNICHSYD AGAILIFLPG YDEIVSLRDR ILFDDKRFAD NAHRYQVFML
HSNMQTLDQK KVLKSPPPGI RKIILSTNIA ETSVTVNDVV FVIDSGKMKE MSFDALSCVT
MLKMVWISKA SAIQRKGRAG RCQPGVCFHL FSRLRFQNML EFQTPELLRM PLQELCLHTK
LLAPVNCPIV DFLMKAPDPP PALIVKNAVQ MLKTIDAMDP WEDLTELGYH LTELPVEPHL
GKMVLCAVIL KCLDPILTIA CTLAYRDPFV LPTLASQKRA AMLCRKRFAA GTFSDHMALL
RAFQAWQKAR SDGWERAFCE KNFLSQATME IIIGMRTQLL GQLRASGFVR ARGGADIRDV
NTNSENWAVV KAALVAGMYP NLVHVDRENL VLTGPKEKKV RFHPTSVLSQ PQYKKIPPAN
GQAAAIQALP TDWVIYDEMT RAHRIANIRC CSVVTPVTVS LFCGPARLPS SSLQEPASFR
EDVVPGDNSD SEVEDKATTN LAVLKLDEWL HLRMEPEAAG LLLQLRQKWH SLFLRHMRAP
SKPWSQADET TIRAITAVLS TEEQSAGLQQ PSGIGQRPRP MTSEELPLAS TWRSTNSRKS
SAETEFSDDS SNAEKVLMKS TPPALHQPKK HKEKKNLHSK RTSDDRSDQS SVKSTDSSSY
PSPCASPSSP ISGKGSKSPS PRPNVPVRYF IMKSSNLQNI DISQQKGIWS TTPNNERKLN
RAFWESSMVY LIFSVQGSGH FQGFARMASE IGSEKSQDWG CAVFGGVFKV EWIRKESIPF
QFAHHLLNPW NDNKKVQISR DSQELEPQVG EQLLQLWDHI PLAGKNSTD
//
