ID   A0A1V9YV32_9STRA        Unreviewed;       598 AA.
AC   A0A1V9YV32;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=cathepsin X {ECO:0000256|ARBA:ARBA00012516};
DE            EC=3.4.18.1 {ECO:0000256|ARBA:ARBA00012516};
GN   ORFNames=THRCLA_09650 {ECO:0000313|EMBL:OQR89649.1};
OS   Thraustotheca clavata.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Thraustotheca.
OX   NCBI_TaxID=74557 {ECO:0000313|EMBL:OQR89649.1, ECO:0000313|Proteomes:UP000243217};
RN   [1] {ECO:0000313|EMBL:OQR89649.1, ECO:0000313|Proteomes:UP000243217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34112 {ECO:0000313|EMBL:OQR89649.1,
RC   ECO:0000313|Proteomes:UP000243217};
RX   PubMed=25527045; DOI=10.1093/gbe/evu276;
RA   Misner I., Blouin N., Leonard G., Richards T.A., Lane C.E.;
RT   "The secreted proteins of Achlya hypogyna and Thraustotheca clavata
RT   identify the ancestral oomycete secretome and reveal gene acquisitions by
RT   horizontal gene transfer.";
RL   Genome Biol. Evol. 7:120-135(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of C-terminal amino acid residues with broad
CC         specificity, but lacks action on C-terminal proline. Shows weak
CC         endopeptidase activity.; EC=3.4.18.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001594};
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQR89649.1}.
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DR   EMBL; JNBS01002694; OQR89649.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V9YV32; -.
DR   STRING; 74557.A0A1V9YV32; -.
DR   OrthoDB; 5475703at2759; -.
DR   Proteomes; UP000243217; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02698; Peptidase_C1A_CathepsinX; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR   InterPro; IPR033157; CTSZ.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   PANTHER; PTHR12411:SF929; CATHEPSIN Z; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 2.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 2.
DR   SUPFAM; SSF54001; Cysteine proteinases; 2.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:OQR89649.1};
KW   Protease {ECO:0000313|EMBL:OQR89649.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243217};
KW   Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..598
FT                   /note="cathepsin X"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012596569"
FT   DOMAIN          42..287
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   DOMAIN          352..590
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   598 AA;  66947 MW;  1907E8D8B61DEA27 CRC64;
     MRIAHLLSLL SVAAAFTKCH QRHPNRTEVL SSALPHEYVT DLPTNFDWRD VNGTNFVTVS
     RNQHIPHYCG SCWAFAATSA LSDRIRIARE RYNDGKDRVL VTREVNLSPQ VLLNCDKEDQ
     GCHGGEGLSA YRYIHENGIP EEGCQRYLAT GHDLGNTCTD IDVCRNCVPS KGCFPQKSYD
     TYHVDEYGTV DGEAKMMAEI YARGPIVCGV AVTDEFLHYA GGVIDDKTGR TDIDHDISIV
     GWGVDEHGTK FWVGRNSWGT YWGEEGWFRL RRGNNNLGVE TDCAFGVPSN NGWPKRKILD
     TTPVKAPVWS SEIGSLLAPP RQNSTCRHPV HFTQGEKILT PRPHEIIDVA TLPKQWDWRN
     IAGVNYVTWD KNQHIPQYCG SCWAQGTTSA LSDRIAILRN ATWPEIALSP QVVINCHGGG
     SCEGGNPGAV YEYAHNHGIP DQTCQAYEAK DGTCSPLRIC ETCWPTDESF SPGKCEVVSK
     FKSYYVSEYG HVRGADQMKA ELYKRGPIGC GMHVTDKFEQ YTGGIYSESI WFPIPNHEIS
     IAGWGYDEET KTEYWIGRNS WGTYWGENGW FRIKMHSDNL GIESDCDWGV PIPDGSQP
//