ID A0A1Z5KL46_FISSO Unreviewed; 645 AA.
AC A0A1Z5KL46;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:GAX26792.1};
DE EC=1.1.99.1 {ECO:0000313|EMBL:GAX26792.1};
GN ORFNames=FisN_9Lh057 {ECO:0000313|EMBL:GAX26792.1};
OS Fistulifera solaris (Oleaginous diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Naviculaceae;
OC Fistulifera.
OX NCBI_TaxID=1519565 {ECO:0000313|EMBL:GAX26792.1, ECO:0000313|Proteomes:UP000198406};
RN [1] {ECO:0000313|EMBL:GAX26792.1, ECO:0000313|Proteomes:UP000198406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCC DA0580 {ECO:0000313|EMBL:GAX26792.1,
RC ECO:0000313|Proteomes:UP000198406};
RX PubMed=25634988; DOI=10.1105/tpc.114.135194;
RA Tanaka T., Maeda Y., Veluchamy A., Tanaka M., Abida H., Marechal E.,
RA Bowler C., Muto M., Sunaga Y., Tanaka M., Yoshino T., Taniguchi T.,
RA Fukuda Y., Nemoto M., Matsumoto M., Wong P.S., Aburatani S., Fujibuchi W.;
RT "Oil accumulation by the oleaginous diatom Fistulifera solaris as revealed
RT by the genome and transcriptome.";
RL Plant Cell 27:162-176(2015).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX26792.1}.
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DR EMBL; BDSP01000252; GAX26792.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Z5KL46; -.
DR InParanoid; A0A1Z5KL46; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000198406; Unassembled WGS sequence.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF213; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Oxidoreductase {ECO:0000313|EMBL:GAX26792.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..645
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013051985"
FT DOMAIN 347..361
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 294
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 645 AA; 71085 MW; 054EF9907C96773B CRC64;
MNALALLLLL FCWYEGAQPT PDDASRCANG ENRTADNTYD YIVVGAGASG GLVASRLARA
GYRTLLLDAG PRFRDEPSVT VPLLWPLSTE DRDIEWRFRS SNSALDPGRD AVLYPRASTI
GGSALHNAML AMYPFPDCFS NLQQLTGDDE FAESKMRARF QRIEKCEYIQ SNNKLLKKGH
GFQGFMSTSL ADLGLAVKPG FLDPQLVAVV NRFLLTAIPQ NPIARFFQSL KKFPKNLPLI
FDINAPGANL REGAHLTPSS ISPAKGSVRS SVADLIYETE QSTSTLTVKD NSFVTQILFD
TTTGDTPIAY GVQVQEGTAL YSIATGPRTV GDETMYFANK EVILAGGTFN TPQILMLSGV
GPSQHLVEHN IPMLVDLPGV GENLHDKLEA TMNWQMPRTW KLFQQGCTFL KPTPEDDPCF
VRFQNGEFPS LYSSSGTLIA IQRKSDPSLP YPDMYVQIVV NKFQGYQDGW VNLTFYDGEE
DTLSIHTMNT RSGPGKGTVR LASSSPFDSV KIDFNGYDDI DLEKTTRVFE DMRKAFRRLQ
RLGVVGEEIA PGYDVKSFDD VKAWVRANGW GHHPMGTAKI GSGDDVMAVV DGQLRVRGVQ
RLRVVDASVF PDQAGFYPMV PVYMMAEKVA DDILRDADST TSQCG
//
