ID A0A287B3Q7_PIG Unreviewed; 1093 AA.
AC A0A287B3Q7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=MOV10 {ECO:0000313|Ensembl:ENSSSCP00000051048.2,
GN ECO:0000313|VGNC:VGNC:90316};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000051048.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000051048.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000051048.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000051048.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
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DR AlphaFoldDB; A0A287B3Q7; -.
DR SMR; A0A287B3Q7; -.
DR STRING; 9823.ENSSSCP00000051048; -.
DR Ensembl; ENSSSCT00000041267.3; ENSSSCP00000051048.2; ENSSSCG00000006776.5.
DR VGNC; VGNC:90316; MOV10.
DR GeneTree; ENSGT00940000156024; -.
DR InParanoid; A0A287B3Q7; -.
DR ChiTaRS; MOV10; pig.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006776; Expressed in blood and 41 other cell types or tissues.
DR ExpressionAtlas; A0A287B3Q7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0035279; P:miRNA-mediated gene silencing by mRNA destabilization; IEA:Ensembl.
DR GO; GO:0035194; P:regulatory ncRNA-mediated post-transcriptional gene silencing; IBA:GO_Central.
DR GO; GO:0141008; P:retrotransposon silencing by mRNA destabilization; IEA:Ensembl.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR049079; Mov-10_helical.
DR InterPro; IPR049077; MOV-10_Ig-like.
DR InterPro; IPR049075; MOV-10_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF537; HELICASE MOV-10; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR Pfam; PF21635; Mov-10_helical; 1.
DR Pfam; PF21633; MOV-10_Ig-like; 2.
DR Pfam; PF21632; MOV-10_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A287B3Q7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 80..108
FT /note="Helicase MOV-10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21632"
FT DOMAIN 146..226
FT /note="Helicase MOV-10 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21633"
FT DOMAIN 284..331
FT /note="Helicase MOV-10 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21633"
FT DOMAIN 383..449
FT /note="Helicase MOV-10 helical"
FT /evidence="ECO:0000259|Pfam:PF21635"
FT DOMAIN 450..539
FT /note="Helicase MOV-10-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21634"
FT DOMAIN 591..661
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 702..779
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 791..1013
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1058..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 122299 MW; 261E49287F885554 CRC64;
MTGLFFSEVH RPPPAVQNQP YFGGEVLSAS PETLKILSVP ILSLCPGPVL PHTEWPSDAV
PSLPAAVPHS PVSSAPGSFG NPTPGFSSML YGMKIANLAY VTRTRVRFFK LDHWADVWFP
EKRRMKLGSE ISKHHRSLLA KIFYDRAEYL HGKHGVDVEV QGPHEARDGQ LLIRLDLNRK
EVLTLRLRNG GTQPVTLTHL FPLCRTPQFA FYNGDQELPC PLGPGEWVSK GKSPWRRAYP
RKKHALAGQW APALARSCLG AVPRLGMLVG GSLRHADSRS RPPPGESYEL HVHCKTSFVG
YFPATVLWEL LGPGEPGSEG AGTFYIARFL AGVAHSPLAA QLKPTTPFKR TQITGNPVVT
NRVEEGERPD RSRNYDLELS MALGTYCPPL RLRQLLPILL QGTNIFTAPK EIAEIKAQLE
AALKWRNYEV KLRLLLHLEE LQMEHDIRHY DLESVPMTWD PIDQNPRLLT LEVPGVAESR
PSVLRGDHLF AVLSSETHQE DAVTYKGFVH RVELDRVKLS FSASLLDRFV DGLTFKVNFT
FNRQPLRVQH RALELTGRWP LWPMLFPVAS RGVPLLPSDV KLKLYDRSLE SNPEQLQAMK
HIVMGTTRPA PYIIFGPPGT GKTVTLVEAI KQVVKHLPKA HILACAPSNS GADLLCQRLR
VHLPSSIYRL LAPSRDIRLV PEDIKPCCNW DAQKGDYVFP AKKKLQEYRV LITTLITASR
LVSAQFPIDH FTHIFIDEAG HSMEPESLVA IAGLLEVKEA DNPGGQLVLA GDPRQLGPVL
RCPLTQKHGL GYSLLERLLT YNALYKKGPD GYNPQFITKL LRNYRSHPTI LDIPNQLYYE
GELQACADVV DRERFCRWEG LPRQGFPIIF HGVMGKDERE GNSPSFFNPE EAATVTSYLK
QLLTSSSKKG KARLSPRSVG VISPYRKQVE KIRHCITKLD KELRGLDDIK DLKVGSVEEF
QGQERSVILI STVRSSQSFV QLDLDFNLGF LKNPKRFNVA VTRAKALLIV VGNPLLLGHD
PDWKAFLEFC KENGGYTGCP FPAKLDLQQG QNLLQGLSKL SPSTSGPRSH NYLPQEGEGG
LPLQVEPEWR NEL
//
