ID A0A2C9KC51_BIOGL Unreviewed; 1430 AA.
AC A0A2C9KC51;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=106050680 {ECO:0000313|EnsemblMetazoa:BGLB017438-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017438-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB017438-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017438-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013061158.1; XM_013205704.1.
DR STRING; 6526.A0A2C9KC51; -.
DR EnsemblMetazoa; BGLB017438-RB; BGLB017438-PB; BGLB017438.
DR GeneID; 106050680; -.
DR KEGG; bgt:106050680; -.
DR VEuPathDB; VectorBase:BGLB017438; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 2..71
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 180..252
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 411..577
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 650..823
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 303..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1158..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 155712 MW; EECB539B0F4C830E CRC64;
MDVKQVLYSW CGKNKVGTPN YEFSVGGPKH RQRFKCEVRL ENFDYVGVGN STNKKDSQAN
AAKDFIQYLV RIGKIKTDEV PPNLLGAAIL EQTLEQDQID GDSKDKCGSS GILPGGTLAP
HLRLQADGIG QEVGAPREFP PYQRGPPLAY MDRIAEKRKL EESEDCDFNA EIHGNWTMEN
AKSRLHQFLQ MHKIKADYKY HVMGPDHNRS FAAEMSFFVK QIGLKLHARE TGSNKQVASK
SCALSLVRQL YHMKVIEPNT GQKKKKGTEK LPPYEVNIGE ELEMKIDQCL KQWGVEPVTY
FEPTEQNSSN EGEPEAPSPV TLINHPSLEE FDPAPAKNTP GVVSWSPPQP NWNPWSNCNI
DEGPLASASL DQISKDLKMA LQIQYAEDEN LKKMLESRAQ LPVHSACETI LFEVNRSPVT
LIRGETGCGK TTQVPQFLLD QMINAGLGAN CNIIVTQPRR ISAVSIAERV AAERSECLGN
SVGYSVRFES VMPRAYGSIL YCTVGTLLRR LEGGLRGVSH VIVDEIHERD INTDFLLVLL
RDMVRVYKEL RIILMSATVD TTLFTDYFGD VAIVEVYGRT YPVQEYYLED IIEMLNFRPP
PEDKRKKHED DDDGGEGDDE NCNKIIAPGY AESTKIAMSQ LSEKEIPFEL VETLLRYIKG
LGVPGAVLFF LPGWNLIFML HKHLEQSPEF GSSRYRILPL HSSIPREDQR RVFEPVPPGV
TKIILSTNIS ETSVTIDDVV YVIDSCKVKM KLFTSHNNMT NYATVWASKT NLEQRRGRAG
RVRAGFAFHL CSKARFEKLE QHATPEIFRT PLHELALSIK LLRLGPIGMF LAKAVEPPPI
DAVIEAEVML RAMRALDAND ELTPLGRLLA KMPIEPRLGK MIIYGCIFYV GDAMCVIAAS
TTFPEPFIVP TDRRRLGWMH KNLAGNRASD HVALLNAFQM WEDARSGGER DEISFCENKL
LNMQTLRMTW EAKNQLRDIL INGGFPEECL LPQSFNFTGP DNKLDIAITL LCLGLYPNVC
YHKEKRKVLT QEFKPALVHK SSVNCSNFTI EFPSPFFIFG EKIRTRAVSC KQMTNISPVQ
LLLFGPRSVC RQGEEVIMDG WLNLKMEFLQ AAKVVALRPP LEALIVRATK NPEGVATPGP
QEETLMALVR ALSRPQAGRH GLEQKGVSPY RNNPPPKMAR SDGFRGGRLG GYGSGFGAGS
TGFGAGRGGG GYGSGLGRGY GGGFGGRDGG GFAERSGSGF GGGYGGGFGG RDRGGFGGRD
GGGFAERSGS GYGGGFGSGA GVDRSGGGYG GESDDGYGGG YGGASGGGYG GASGGGYNVA
SGGGYGGSSG GGFGGSLVQG GRGGYGGGNY GRFNTGGGDS FNSKGSFGGR LSDGFDSGYN
YDRQSSGFGT EGIGGFGDES NWRGPSSLTG GNGNAGGYSQ YRGGDYGGGY
//
