ID   A0A2C9LA74_BIOGL        Unreviewed;       350 AA.
AC   A0A2C9LA74;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Cysteine dioxygenase {ECO:0000256|ARBA:ARBA00013133, ECO:0000256|RuleBase:RU366010};
DE            EC=1.13.11.20 {ECO:0000256|ARBA:ARBA00013133, ECO:0000256|RuleBase:RU366010};
GN   Name=106078701 {ECO:0000313|EnsemblMetazoa:BGLB028891-PC};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB028891-PC, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB028891-PC}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB028891-PC};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC         Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC         Evidence={ECO:0000256|RuleBase:RU366010};
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|RuleBase:RU366010};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000256|RuleBase:RU366010};
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine
CC       from L-cysteine: step 1/2. {ECO:0000256|ARBA:ARBA00004759,
CC       ECO:0000256|RuleBase:RU366010}.
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006622, ECO:0000256|RuleBase:RU366010}.
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DR   RefSeq; XP_013095153.1; XM_013239699.1.
DR   AlphaFoldDB; A0A2C9LA74; -.
DR   EnsemblMetazoa; BGLB028891-RC; BGLB028891-PC; BGLB028891.
DR   VEuPathDB; VectorBase:BGLB028891; -.
DR   OrthoDB; 314969at2759; -.
DR   UniPathway; UPA00012; UER00537.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0017172; F:cysteine dioxygenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042412; P:taurine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd10548; cupin_CDO; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR010300; CDO_1.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR12918; CYSTEINE DIOXYGENASE; 1.
DR   PANTHER; PTHR12918:SF1; CYSTEINE DIOXYGENASE TYPE 1; 1.
DR   Pfam; PF05995; CDO_I; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000256|RuleBase:RU366010};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR610300-51};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR610300-51};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU366010};
KW   Thioether bond {ECO:0000256|ARBA:ARBA00022784,
KW   ECO:0000256|PIRSR:PIRSR610300-50}.
FT   BINDING         85
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610300-51"
FT   BINDING         87
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610300-51"
FT   BINDING         138
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610300-51"
FT   CROSSLNK        92..155
FT                   /note="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610300-50"
SQ   SEQUENCE   350 AA;  38828 MW;  1EDB6594E110F0E1 CRC64;
     MPMTEGKMSL EKLLTNIEAQ FQGDTCNVGA VGELIHNYKS NKVDWEKYAF SNPAEGYSRN
     LVVEKSGKFN ALILCWQPGK GSKIHAHEGS NCFLKVLQGE LREEMFDWPT KVCQMIPREE
     KIYTDGDLNL MTDDKGLHRV TNNNKSEMTI SLHIYLPPFR HCSWFEEETG KEVRAEMTFT
     SIEGKRTEVK GSYNPLAGTS TEQQLSTMFT DVSKCCPEKC GNPKCAKQCE NTCCPEKCDG
     PQCAKHCEDS CCPEKCDGPK CAKHCEDSCC PEKCGDGPKC AKQCEDSCCP EKCGDGPKCA
     KQCEDSCCPE KCDGPKCAKQ CEDSCCPENC DGPKCAKQCE DTCCPEKHCG
//