ID A0A2I0IA07_PUNGR Unreviewed; 1225 AA.
AC A0A2I0IA07;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=CRG98_038822 {ECO:0000313|EMBL:PKI40811.1};
OS Punica granatum (Pomegranate).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Lythraceae; Punica.
OX NCBI_TaxID=22663 {ECO:0000313|EMBL:PKI40811.1, ECO:0000313|Proteomes:UP000233551};
RN [1] {ECO:0000313|EMBL:PKI40811.1, ECO:0000313|Proteomes:UP000233551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AG2017 {ECO:0000313|Proteomes:UP000233551};
RC TISSUE=Leaf {ECO:0000313|EMBL:PKI40811.1};
RA Akparov Z., Amiraslanov A., Hajiyeva S., Abbasov M., Kaur K., Hamwieh A.,
RA Solovyev V., Salamov A., Braich B., Kosarev P., Mahmoud A., Hajiyev E.,
RA Babayeva S., Izzatullayeva V., Mammadov A., Mammadov A., Sharifova S.,
RA Ojaghi J., Eynullazada K., Bayramov B., Abdulazimova A., Shahmuradov I.;
RT "De-novo sequencing of pomegranate (Punica granatum L.) genome.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKI40811.1}.
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DR EMBL; PGOL01003489; PKI40811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0IA07; -.
DR STRING; 22663.A0A2I0IA07; -.
DR Proteomes; UP000233551; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009536; C:plastid; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18598; ABC_6TM_MRP7_D1_like; 1.
DR CDD; cd18605; ABC_6TM_MRP7_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF330; ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233551};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 186..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..339
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 375..602
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 666..953
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 988..1221
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1225 AA; 135907 MW; ABA00EF088A4B1EF CRC64;
MNRGVLKQLD FEDLLPLPTD MNPSSCHEKL QSCWEAQWNQ NDSDPSLFRS LFHAYGWAYL
SLGLLKVIND CIGFAGPLLL NRLIRFLERG SGHLEGYVLA VSLGGTSIVK SFLDTQYSFR
VAKLKLKLRS SIMTVIYQKC LRVGLAERSR FSVGEIQTFM SVDADRTVNL CNSFHDMWSL
PLQIGVALYL LYTQVKFAFV AGVAITVLLI PVNKWISELI ASATQKMMKQ KDERIRRTGE
LLAHIRTLKM YGWELLFSDW LMETRSSEVK HLSTRKYLDA WCVFFWATTP TLFSLCTFGL
FTLMGHQLDA ATVFTCLALF NTLISPLNSF PWVINGLIDA FISIRRLSRF LSCSEHQYQQ
WKLVDSPYSS GNVAVVMEDA CCDWSSSKSE ELNIIINHIT LTLPKGLLVA IIGEVGSGKS
SLLNSILGEM RLLHGSIRSA RSVAYVPQAP WILSGTVRDN ILFGNNYDSK RYCDTLQACA
LDVDVSVMAG GDMAHIGEKG VNLSGGQRAR IGLARALYHS ADILMLDDVL SAVDAQVAQW
ILNNAILGPL MDQKTCLLCT HNVQAISRAD MVVVMEKGGV MWVGQPAELA ISEYSAFLTL
TWSNALLQCP VQESCMSSSE VREETELLSA LEIAQEIIEE ELRKEGRVEL IVYKKYAAFA
GSLIAFVILL SAVSMQASRN GSDLWLSYWV DTTKGSSETA SSTTFYLVIL CLFCVMNSFL
TLVRAFLFAY GGLRAAVKVH ATLLCKIVNA PVKFFNQTPS GRILNRFSSD LYTIDDSLPF
ILNILLANFV GLLGIAVVLS YVQVLFLFLL LPFWFIYSRL QFFYRSTSRE LRRLDSVTRS
PIYSSFTETL DGSSTIRAFN SQDFFWAKFI EHVALYQRTS LSELIASLWL SLRLQLLAAF
IISFVAITSV IGSRGNLPVS FGTPGLVGLA LSYAAPIVSL LGSFLTSFTE TEKEMVAVER
ALQYVDIPEE ELGGCQLANL DWPSQGLIEF QNVTLRYGPT LPPALRNLTF TIPGGMQVGV
VGRTGAGKSS ILNALFRLNP ICSGCILVDG LNINNVPVRD LRSSFAVVPQ SPFLFEGSLR
DNLDPFRMTD DIKIWDVLEK CHLKDEVEAA GGLDLHIKES GMSFSVGQRQ LLCLARALLK
SSKVLCLDEC TASIDTRTAS LLQKTLSSGC KGTTVITIAH RISTVQDMDC ILVLDHGVLV
EQGDPKDLLE DEFSRFSSFA KASTM
//
