ID A0A2K6CAT8_MACNE Unreviewed; 5521 AA.
AC A0A2K6CAT8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2D {ECO:0000313|Ensembl:ENSMNEP00000020761.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000020761.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000020761.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 9545.ENSMNEP00000020761; -.
DR Ensembl; ENSMNET00000045010.1; ENSMNEP00000020761.1; ENSMNEG00000034150.1.
DR GeneTree; ENSGT00940000156707; -.
DR OMA; EFHYVDT; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034150; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR CDD; cd15695; ePHD1_KMT2D; 1.
DR CDD; cd15698; ePHD2_KMT2D; 1.
DR CDD; cd22027; HMG-box_KMT2D; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15597; PHD3_KMT2D; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15601; PHD5_KMT2D; 1.
DR CDD; cd19209; SET_KMT2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 6.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041961; KMT2D_ePHD1.
DR InterPro; IPR041964; KMT2D_ePHD2.
DR InterPro; IPR047000; KMT2D_PHD3.
DR InterPro; IPR046999; KMT2D_PHD5.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037890; SET_KMT2D.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE 2D; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 7.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00184; RING; 6.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 104..218
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 226..276
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 229..274
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 273..323
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1377..1430
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1427..1477
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1504..1559
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 5013..5121
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 5381..5497
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 5505..5521
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1610..1767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1904..2001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2167..2683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2697..2787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..2977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3077..3212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3263..3330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3463..3500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3597..3675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3758..3802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3966..4171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4217..4409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4487..4528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4597..4711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4805..4840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4889..4964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3718..3745
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..477
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..513
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..713
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..741
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..888
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..917
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..944
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1021
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1052
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1081
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1744..1767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1973..2001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2186..2207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2346..2361
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2398
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2442..2476
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2545..2564
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2570..2607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2729..2744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3163..3182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3264..3290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3463..3488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3597..3631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3781..3796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3966..3981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4005..4039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4056..4119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4126..4151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4217..4241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4287..4305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4321..4337
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4369..4383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4498..4528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4604..4618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4631..4653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4811..4825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4893..4911
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4922..4940
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4946..4964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5521 AA; 591284 MW; 0447EE1D189D07A8 CRC64;
MDSQKLPGED KDSEPAADGP AASEDPSATE SDLPNPHVGE VSVPSSGSPS LQETPQDCSG
GPVRRCALCN CGEPSLHGQR ELRRFELPFD WPRCPVVSPG GSPGPNEAVL PSEDLSQIGF
PEGLTPAHLG EPGGSCWAHH WCAAWSAGVW GQEGPELCGV DKAIFSGISQ RCSHCTRLGA
SIPCRSPGCP RLYHFPCATA SGSFLSMKTL QLLCPEHSEG AAHLEEARCA VCEGPGELCD
LFFCTSCGHH YHGACLDTAL TARKRAGWQC PECKVCQACR KPGNDSKMLV CETCDKGYHT
FCLKPPMEEL PAHSWKCKAC RVCRACGAGS AELNPNSEWF ENYSLCHRCH RAQGGQPVSS
VAEQHTPVCS RFSPPESGDT PTDEPDALYV ACQGQPKGGH VTSMQPKEPG PLQCEAKPLG
RAGVQLEPQL EAPLNEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP PEDSPASPLP
EALHLSRPPE ESPLSPPPEE SPLSPPPESS PFSPLEESPF SPLEESPPSP ALETPLSPPP
EASPLSAPFE ESPLSPPPEE LPTSPPPEAS RLSPPPEESP MSPPPEESPM SPPPEASRLF
PPFEESPLSP PPEESPLSPP PEASRLSPPP EDSPMSPPPE ESPMSPPPEV SRLSPLPVVS
RLSPPPEESP LSPPPEESPT SPPPEDSPTS PPPENSPTSP PPENSPTSPP PEDSLMSLPL
EESPLSPLPE EPQLCPPSEE PHLSPRPEEP HLSPRPEEPH LSPQPEEPHL SPQPEEPCLC
AVPEEPHLSP QAEGPHLSPQ PEELHLSPQT EEPHLSPVPE EPFLSPQPEE SHLSPQSEEP
CLSPRPEESH LSPQLEEPPL SPRPEEHPEE PGQCPAPEEL PLFPPAGEPS LSPLLGEPAL
SEPGEPPLSP LPEELPLSPS GEPSLSPQLM PSDPLPPPLS PIITAVAPPA LSPLGELEYP
FGAKGDSDPE SPLAAPILET PISPPPEANC TDPEPVPPMI LPPSPGSPVG PASPILMEPL
PPQCSPLLQH SLAPQNSPPS QCSPPALPLS VPSPLSPIGK VVGVSDEPEL HEMETEKVPE
PECPALEPSA TSPLPSPMGD LSCPAPSPAP ALDDFSGLGE DTAPLDGIDA PGSQPEAGQT
PGSLASELKG SPVLLDPEEL APVTPMEVYP ECKQTAGQGS PCEEQEEPRA PVAPTPPTLI
KSDIVNEISN LSQGDASASF PGSEPLLGSP DPEGGGSLSM ELGVSTDVSP ARDEGSLRLC
TDSLPETDDS LLCDAGTAIS GGKTEGEKGR RRSSPARSRI KQGRSSSFPG RRRPRGGAHG
GRGRGRARLK STASSIETLV VADIDSSPSK EEEEEDDDTM QNTVVLFSNT DKFVLMQDMC
VVCGSFGRGA EGHLLACSQC SQCYHPYCVN SKITKVMLLK GWRCVECIVC EVCGQASDPS
RLLLCDDCDI SYHTYCLDPP LLTVPKGGWK CKWCVSCMQC GAASPGFHCE WQNSYTHCGP
CASLVTCPIC HAPYVEEDLL IQCRHCERWM HAGCESLFTE DDVEQAADEG FDCISCQPYV
VKPVAPVAPP ELVPMKVKEP EPQYFRFEGV WLTETGMALL RNLTMSPLHK RRQRRGRLGL
PGEAGLEGSE PSEALGPDDK KDGDLDTDEL LKGEGGVEHM ECEIKLEGPV SPDVEPGKEE
TEESKKRKRK PYRPGIGGFM VRQRKSHTRT KKGPAAQAEV LSGDGQPDEV IPADLPAEGT
VEQSLAEGDE KKKQQRRGRK KSKLEDMFPA YLQEAFFGKE LLDLSRKALF AVGVGRPSFG
LGTPKAKGDG GSERKELPTS QKGDDGPDIA DEESRGLEGK ADTPGPEDGG VKASPVPSDP
EKPGTPGEGM LSSDLDRIST EELPKMESKD LQQLFKDVLG SEREQHLGCG TPGLEGSRTP
LQRPFLQGGL PLGNLPSSSP MDSYPGLCQS PFLDSRERGG FFSPEPGEPD SPWTGSGGTT
PSTPTTPTTE GEGDGLSYNQ RSLQRWEKDE ELGQLSTISP VLYANINFPN LKQDYPDWSS
RCKQIMKLWR KVPAADKAPY LQKAKDNRAA HRINKVQKQA ESQINKQTKV GDIARKTDRP
ALHLRIPSQP GALGSPPPAA APTIFIGSPA TPAGLSTSAD GFLKPPAGSV PGPDSPGELF
LKLPPQVPAQ VPSQDPFGLT PAYPLEPRFP TAPPTYPPYP SPTGAPAQPP MLGASSRPGT
GQPGEFHTTP PGTPRHQPST PDPFLKPRCP SLDNLAVPES PGVGGGKASE PLLSPPPFGE
SRKALEVKKE ELGASSPSYG PPNLGFVDSP SSGPHLGGLE LKTPDVFKAP LTPRASQVEP
QSPGLGLRPQ EPPPAQALAP SPPSHPDIFR TGSYPDPYAQ PPLTPRPQPP PPESCCALPP
RSLPSDPFSR VPASPQSQSS SQSPLTPRPL SAEAFCPSPV TPRFQSPDPY SRPPSRPQSR
DPFAPLHKPP RPQPPEVAFK AGSLAHTSLG AGGFPAALPS GPAGELHTKV PSGQPPNFVR
SPGTGAFVGT PSPMRFTFPQ AVGEPSLKPP VPQPGLPPPH GINSHFGPGP TLGKPQSTNY
AVATGNFHPS GSPLGPSSGS TGESYGLSPL RPPSVLPPPA PDGSLPYLSH GASQRSGITS
PVEKREDPGA GMGSSLATPE LPGTQDPGMS GLSQTELEKQ RQRQRLRELL IRQQIQRNTL
RQEKETAAAA AGAVGPPGSW GAEPSSPAFE QLSRGQTAFA GTQDKSNLVG LPPGKLSGPI
LGQGSFPGDD RLSRPPPPAT PSSMDVNSRQ LVGGSQAFYQ RAPYPGSLPL QGQQQQLWQQ
QQATAATSMR FAMSARFPST PVPELGRQAL GSPLAGIPTR LPGPGEPVPG PAGPAQFIEL
RHNVQKGLGP GGTPFPGQGP PQRPRFYPVS EDPHRLAPEG LRGLAVSGLP PQKPSAPPAP
ELNNSLHPTP HTKGPTLPTG LELVSRPASS TELGRPTPLA LEAGKLPCED PELDDDFDAH
KALEDDEELA HLGLGVDVAK GDDELGTLEN LETNDPHLDD LLNGDEFDLL AYTDPELDTG
DKKDIFNEHL RLVESANEKA EREALLRGVE PGPLGPEERP PPAADASEPR LASVLPEVKP
KVEEGGRHPS PCQFTIATPK VEPAPAANTL GLGLKPGQSV MGSRDTRMGT GPFSSSGHTA
EKGSFGATGG PPAHLLTPSP LSGPGGSSLL EKFELESGAL TLPGGPVASG DELDKMESSL
VASELPLLIE DLLEHEKKEL QKKQQLSAQL QPAQQQQQQQ QQQHSLLSAP GPAQAMSLPH
EGSSPSLAGS QQQLSLGLGG ARQPGLPQPL MPTQPPAHAL QQRLAPSMAM VSNQGHMLSG
QHGGQAGLVP QQSSQPVLSQ KPMGTMPPSM CMKPQQLAMQ QQLANSFFPD TDLDKFAAED
IIDPIAKAKM VALKGIKKVM AQGSIGVAPG MNRQQVSLLA QRLSGGPGSD LQNHVAPGSG
QERSAGDPSQ PRPNPPTFAQ GVINEADQRQ YEEWLFHTQQ LLQMQLKVLE EQIGVHRKSR
KALCAKQRTA KKAGREFPEA DAEKLKLVTE QQSKIQKQLD QVRKQQKEHT NLMAEYRNKQ
QQQQQQQQQQ QQQQHSAVLA LSPSQSPRLL SKLPGQLLPG HGLQPPQGPP GGQAGGLRLP
PGGMALPGQP GGPFLNTALA QQQQQQHSGG AGSLAGPSGG FFPGNLALRS LGPDSRLLQE
RQLQLQQQRM QLAQKLQQQQ QQQQQHLLGQ VAIQQQQQQG PGVQTNQALG PKPQGLLPPS
SHQGLLVQQL SPQPPQGPQG MLGPAQVAVL QQQHPGALGP QGPHRQVLMT QSRVLSSPQL
AQQGQGLMGH RLVTAQQQQQ QQQHQQQGSM AGLSHLQQSL MSHSGQPKLS TQPMGSLQQL
QQQQQQQQQL QQQQQLQQQQ LQQQQQQQQL QQQQQQLQQQ QQQLQQQQQQ QQQQLQQQQQ
QQQQHRTLLS PQQQQQQQVA LGPGMPAKPL QHFSSPGALG PTLLLTGKEQ NTVDPAVSSE
VTEGPSTHQG GSLAIGTTPE SMATEPGEVK PSLSGDSQLL LIQPQPQPQS SSLQLQPPLR
LPGQQQQQVS LLHTAGGGSH GQLGSGSSSE ASSMPHLLAQ PSVSLGEQPG PMTQNLLGPQ
QPMLERPMQN NTGPQPPKPG PVLQSGQGLP GVGIMPTVGQ LRAQLQGVLA KNPQLRHLSP
QQQQQLQALL MQRQLQQSQA VRQTPPYQEP GTQTSPLQGL LGCQPQLGGF PGSQTGPLQE
LGAGPRPQGP PRLPAPPGAL STGPVLGPVH PTPPPSSPQE PKRPSQLPSP SSQLPTEAQL
PPAHPGTPKP QGPTLELPPG RVSPAAAQLA DTLFGKGMGP WDPPDNLAET QKPEQSSLVP
GHLDQVNGQV VPEAPQLSIK QEPREEPCAL GAQSVKREAN GEPIGAPGTS NHLLLAGPRS
EAGHLLLQKL LRAKNVQLST GRGSEGLRAE INGHIDSKLA GLEQKLQGTP SNKEDAAARK
PLTPKPKRVQ KASDRLVSSR KKLRKEDGVR ASEALLKQLK QELSLLPLTE PAITANFSLF
APFGSGCPVN GQSQLRGAFG SGALPTGPDY YSQLLTKNNL SNPPTPPSSL PPTPPPSVQQ
KMVNGVTPSE ELGEHPKDAA SARDTEGALR DTSEVKSLDL LAALPTPPHN QTEDVRMESD
EDSDSPDSIV PASSPESILG EEAPRFPHLG SGRWEQEDRA LSPVIPLIPR ASIPVFPDTK
PYGALDLEVP GKLPATTWEK GKGSEVSVML TVSAAAAKNL NGVMVAVAEL LSMKIPNSYE
VLFPEGPARA GTEPKKGEAE GPGGKEKGLG GKSQDTGPDW LKQFDAVLPG YTLKSQLDIL
SLLKQESPAP EPPTQHSYTY NVSNLDVRQL SAPPPEEPSP PPSPLAPSPA SPATEPLVEL
PAEPLAEPPV PSPLPLASSP ESARPKPRAR PPEEGEDSRP PRLKKWKGVR WKRLRLLLTV
QKGSGRQEDE REVAEFMEQL GTALRPDKVP RDMRRCCFCH EEGDGATDGP ARLLNLDLDL
WVHLNCALWS TEVYETQGGA LMNVEVALHR GLLTKCSLCQ RTGATSSCNR MRCPNVYHFA
CAIRAKCMFF KDKTMLCPMH KIKGPCEQEL SSFAVFRRVY IERDEVKQIA SIIQRGERLH
MFRVGGLVFH AIGQLLPHQM ADFHSATALY PVGYEATRIY WSLRTNNRRC CYRCSIGENN
GRPEFIIKVI EQGLEDLVFT DASPQAVWNR IIEPVAAMRK EADMLRLFPE YLKGEELFGL
TVHAVLRIAE SLPGVENCQN YLFRYGRHPL MELPLMINPT GCARSEPKIL THYKRPHTLN
STSMSKAYQS TFTGETNTPY SKQFVHSKSS QYRRLRTEWK NNVYLARSRI QGLGLYAAKD
LEKHTMVIEY IGTIIRNEVA NRREKIYEEQ NRGIYMFRIN NEHVIDATLT GGPARYINHS
CAPNCVAEVV TFDKEDKIII ISSRRIPKGE ELTYDYQFDF EDDQHKIPCH CGAWNCRKWM
N
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