ID A0A2K6GWB9_PROCO Unreviewed; 439 AA.
AC A0A2K6GWB9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
GN Name=LCAT {ECO:0000313|Ensembl:ENSPCOP00000030525.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000030525.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000030525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR RefSeq; XP_012516016.1; XM_012660562.1.
DR AlphaFoldDB; A0A2K6GWB9; -.
DR STRING; 379532.ENSPCOP00000030525; -.
DR Ensembl; ENSPCOT00000041473.1; ENSPCOP00000030525.1; ENSPCOG00000027983.1.
DR GeneID; 105823374; -.
DR KEGG; pcoq:105823374; -.
DR CTD; 3931; -.
DR GeneTree; ENSGT00940000160052; -.
DR OMA; PWQWVPL; -.
DR OrthoDB; 353098at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:Ensembl.
DR GO; GO:0034186; F:apolipoprotein A-I binding; IEA:Ensembl.
DR GO; GO:0004607; F:phosphatidylcholine-sterol O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0047179; F:platelet-activating factor acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0004771; F:sterol esterase activity; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Ensembl.
DR GO; GO:0090107; P:regulation of high-density lipoprotein particle assembly; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..439
FT /note="Phosphatidylcholine-sterol acyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014366636"
SQ SEQUENCE 439 AA; 49681 MW; 845BF5A043F59EA6 CRC64;
MGPPGSLWQW GLLVGLLLPP AAPFWLLNVL FPPHATPKAE LNNHTRPVIL VPGCLGNQLE
AKLDKPDVVN WMCYRKTEDF FTIWLDLNVF LPLGVDCWID NTRVVYNRSS GLLSNAPGVQ
IRVPGFGKTY SVEYLDTSKL AGYMHTLVQN LVNNGYVRDE TVRAAPYDWR LEPSQQEEYY
RKLARLVEEM HAAYGKPVFL VGHSLGCLHL LYFLLRQPQS WKDRFIDGFI SLGAPWGGSI
KPMLVLASGD NQGIPIMSSI KLREEQRITT TSPWMFPSTM AWPEDHVFIS TPSFNYTGRD
FQRFFADLRF EEGWYMWLQS RDLLKGLPAP GVEVYCLYGV GLPTPHTYIY DHDFPYTDPV
GALYEDGDDT VATRSSDLCG RWQSRQPQPV HLLPLHGLQH LNMVFSNQTL EHINSILLGA
YRQGSPASAS ASPEPLPPE
//
