ID A0A2N3N4U3_9PEZI Unreviewed; 1373 AA.
AC A0A2N3N4U3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=jhhlp_006050 {ECO:0000313|EMBL:PKS07446.1};
OS Lomentospora prolificans.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Microascaceae; Lomentospora.
OX NCBI_TaxID=41688 {ECO:0000313|EMBL:PKS07446.1, ECO:0000313|Proteomes:UP000233524};
RN [1] {ECO:0000313|EMBL:PKS07446.1, ECO:0000313|Proteomes:UP000233524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHH-5317 {ECO:0000313|EMBL:PKS07446.1,
RC ECO:0000313|Proteomes:UP000233524};
RX PubMed=28963165; DOI=10.1534/g3.117.300107;
RA Luo R., Zimin A., Workman R., Fan Y., Pertea G., Grossman N., Wear M.P.,
RA Jia B., Miller H., Casadevall A., Timp W., Zhang S.X., Salzberg S.L.;
RT "First Draft Genome Sequence of the Pathogenic Fungus Lomentospora
RT prolificans (Formerly Scedosporium prolificans).";
RL G3 (Bethesda) 7:3831-3836(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKS07446.1}.
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DR EMBL; NLAX01000701; PKS07446.1; -; Genomic_DNA.
DR STRING; 41688.A0A2N3N4U3; -.
DR VEuPathDB; FungiDB:jhhlp_006050; -.
DR InParanoid; A0A2N3N4U3; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000233524; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022257; PHM7_ext.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233524};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 167..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 984..1158
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1193..1342
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 152504 MW; 41C72258EC7E2827 CRC64;
MADGRRKRQL QGAQDNNATS GQPIPTSETV DDNAPSRQED IEKAVSTLPD VNGSVAAQWI
RARERPHHRP IANFFRRVDT IKWTRNRLKI LTPAIRKMKR RLLAGEGKPL PAAFIEFTTQ
AEAELAYQAQ AHHSPMHMSP RFIGVRPDEI IWSVLNMGWA ERIIRRFVVL AGVTAAIIFW
SFPSAFIGLL SNISFLAETF PFLSWIVKLP DAITGVLQGF LPAFFLSLVM AAVPWMLRGC
ARVAGIPSLS MIELFVQNAY FAFQVIQVFL VTTITSAASG AVTAIIKDPL SVKDLLSENL
PKSSNFYISY ILLQCLAAGA NALVHIIEIV RHHLMSKRLD SPRMKFNIWH RVRRIHWGGV
FPIFTNMGVI AISYACISPL VLGFATVGLY VIYLVYRYNL LYIYNTEIDT RGLVYPRALL
QLLVGLYLAE VCMIGLFALR SAFAPMMIMI VFLVLSVLIH FSINDAISPL LYNLPRTLPF
ENEELAAGCR PFEVGQNDVI RNEPVGQGSS GPNSNSTSRP HDSFDVVDNE DGKVEVEEHF
TARSRGLGTR GVEGAEGFVT SILDTTKDSI AKRLQGHADA LGLTVVQGYF QYWIKPDRNI
KPNFVLKWLH PGIFQDFATL QHMLPPGMPD PTESYPDDYA HHAYWPPVMT TPLETLWIPR
DEGGVSKQEV KHSGEVIEIT DEGAWLNENG RVEVDLDKAP PPGVAKSYDP RQPSSPRLLT
LVWYSIDFSA SQLMPSAENI AVVTTDAPVI DKVKKEKKVK KEKKDKKEKK KKLKTNDVES
LIPAEIGINE SVMADDNGEI EKKKKKEKKK EKKEKKEKKK AKRLDSAENN TEAEDTPMAE
APTEESDKKS SKKKRKHDQV TEDVADVANG ADATESESKP KKKSKKEGKK DGKKENGIET
NGATDGRHDA PNGSYSQSSA LSDVPQSEID DFLKTKFVTI TDPTGKLSHL RPIVQFSHLP
STPLLRKNPF KAFSAPTPIQ AASWPFTLSR RDVIGVAETG SGKTMAFALP CVEGLSKGPK
NRSVKAVVVS PTRELAMQTH EQVSQLAGLV GLSCVCVYGG APKPEQRNLL GRGADIVVAT
PGRLRDFMSE GVCDLSNVQF AVLDEADRML DTGFEEDIKQ ILAATPPREK RQTLMFTATW
PLSVQALAAS MMVDPVRINI SNSDEDRADG ELQANKRITQ RVEVIDPRAK EGRLLQILRE
YQQGSKRNDR ILVFALYKKE ATRVEETLAR KGIRVAGIHG DLKQEQRTRS LEAFKAGTTS
VLVATDVAAR GLDIPEVKLV INLTFPLTIE DYVHRIGRTG RAGKTGEAIT LFTQHDKSHS
GELINILKQA GQPVPEDLLK FGTTVKKKLH PVYGAFYRDV DTTNVPEKIV FDD
//
