ID A0A2U1QFV2_ARTAN Unreviewed; 1390 AA.
AC A0A2U1QFV2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=CTI12_AA035180 {ECO:0000313|EMBL:PWA96896.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA96896.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA96896.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA96896.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA96896.1}.
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DR EMBL; PKPP01000154; PWA96896.1; -; Genomic_DNA.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd00048; DSRM_SF; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:PWA96896.1};
KW Helicase {ECO:0000313|EMBL:PWA96896.1};
KW Hydrolase {ECO:0000313|EMBL:PWA96896.1};
KW Nucleotide-binding {ECO:0000313|EMBL:PWA96896.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 829..1004
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 155551 MW; 10763BF4107112F9 CRC64;
MAPKKKQQQQ KSSKHKPSSS STGPKLQISA ENENRLRRLL LTSGRSTAAV TVPEESNLTK
AQKAKKLHSV YEKLSCEGFS DDSIERALSH LKESATFEGA LDWLCLILPP NELPLKFRSN
TAALPDDGGS VGIISTARDD WAPLPDSPVA TENEMPEVTI KSKGQRKVDT LDTFQQSQAD
WIRQYMEQQE EDEYESWEDA ADADDKASEP RSYEIIREEY HSARLQAINA KERRDKKGQE
QSGQIIRKLK QEMAALGISV DTLAAEFESR HRVIEESPSK NLDAVICEED VCIDSSVEQM
GPEDNEIVTE KFSEAVSTQG ISSSVPSQEG TVADEDPGDI ELGDMFLEDS SSSQVLHPDI
VELQKKEKMK ELTSEKNLEK LEGIWKKGDP LKMPKAILHQ LCQRSGWEAP KYSKVQGTRD
GFSYTVSVIR KASGRGKNRK VGGLTTLQLP TPGETFENAE DAQNRVAAFA LYQLFPDLPV
HMMMTKPYMS LVLQWLEGDL SGDLKEPEVD RRAGFVDSLL DADASDAIVS VDASDISVKN
DSHISHAQED KSSRDAGIDK NAESIDYHKQ AESSYLKKQH ESKRKTKKYE DMLKSRAALP
IAELKGEILH LLKENDVLVV CGETGCGKTT QVPQFILDDM IEEGHGGICN IVCTQPRRIA
AISVAERVAD ELHERSLLGD FLLIILKSFI EKQSTQRTQK LKVILMSATV DSQLFSHYFG
DCPVIHAQGR THPVTTHFLE DIHESTDYRL ASDSPASLRS DAPKHKLQGA AVDNHRGKKN
LVISAWGDES VLSKGNTNPY YVPENYQTYS EQTQQNLKKL NEDVIDYDLL EDLICHVDET
YPEGAILVFL PGVAEIHTLL DKLAASYQFR GEASEWLLPL HSNIASSEQK KVFQRPADGI
RKVIIATNIA ETSITIDDVV YVIDCGKHKE NRYNPRKKLS SMVEDWISRA NARQRRGRAG
RVKPGICFCL YTRHRFEKLM RPFQLPEMLR MPLVELCLQI KLLSLGRIMP FLQKALEPPT
EEAITSAVSL LYEVGAVDGD EELTPLGYHL AKLPVDVLIG KMMLYGGIFG CLSPILSISA
FLSYKSPFIY PKDERHAVDR AKLALLTDKA GGANDQDNGD RQSDHLIMMI AYKKWDKILR
ENGAHAAERF CKSHFLSSSV MYMIRDMRVQ FGTLLADIGL IDLPKNYQSG GKWREKLDSW
FSDASQTFNV YSNHSSVVKA LLCAGLYPNV AATEQGISEK ALNSLRQSAG PATEDSNVWF
DGRRVVHVHP TSVNSNTKTF QHPFLVFLEK VETTKVFLRD TTITSPYSIL LFGGSMNIQH
QTGLVIIDGW LKMAAPAQTA VLFKELRLTL HSILEELIRK PQTANIAENS VIQSIVHLLL
EEDKPKIHHR
//
