ID A0A2Y9QTN8_TRIMA Unreviewed; 1276 AA.
AC A0A2Y9QTN8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=LOC101343570 {ECO:0000313|RefSeq:XP_023582709.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023582709.1};
RN [1] {ECO:0000313|RefSeq:XP_023582709.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR RefSeq; XP_023582709.1; XM_023726941.1.
DR AlphaFoldDB; A0A2Y9QTN8; -.
DR STRING; 127582.A0A2Y9QTN8; -.
DR KEGG; tmu:101343570; -.
DR InParanoid; A0A2Y9QTN8; -.
DR OrthoDB; 5351296at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd20434; Tudor_TDRD12_rpt1; 1.
DR CDD; cd20435; Tudor_TDRD12_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047390; Tudor_TDRD12_rpt1.
DR PANTHER; PTHR22655:SF2; ATP-DEPENDENT RNA HELICASE TDRD12-RELATED; 1.
DR PANTHER; PTHR22655; UNCHARACTERIZED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00567; TUDOR; 2.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51203; CS; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Helicase {ECO:0000313|RefSeq:XP_023582709.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 1131..1217
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 1086..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1242..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 144994 MW; 21CD9F8F2F38D4D1 CRC64;
MLEVLVLKIE DPGCFWVVIK GYSPFLDHEV DYQKLNSAMN DFYNSRCQDR KIKPLLLEEG
QVCVVYCQEL KCWCRAIIKS IMSSADHYLA ECFLVDFAKY IPVKSKNIRV AVEAFMQLPY
RAKKFGLYCT KPVTLHIDIC EDSAEIVPAR KWDSAAIQYF QNILKATTHV EAKLCAVEED
TFEVYLYVTI KSEKVCVNDD LVAKNFACYV SPTENKILDC LEKARLNIKS ASFSNKLNPA
LTLWPMFLQG KASQGIKNKA VKCNTEPMKD SPKKKAEKKQ QCVPLKGVNE YVESSAYWPT
RRGITIYADP DIPAASVLCQ KPKEKPLRLA EKKEYDEKNG CLKLLQFLNP DPLRADGISD
LQQLQKLKLG LQQPFVVLGN KIEPCLTIEM SPLSADLKKA LQRNKFPGPS HTESYSWPPI
ARGCDVVVIS HCGNDPLLYL PPVLTILQTG GCYKSLPSRN GPLAVIVCPG WKKAQFIFQL
LGDYSMSSRP LHPMLLTIGL HKDEAKNMKL PRGCDVIVTT PHSLLRLLKY QSLLFLRVCH
LILDEVEVLL FEANEQMFAI LDNFKKNIEI EERESAPHQI IAVGVHWNKH IDHLIKEFMY
DPYVVITAME EAALYGSVQQ VVHLCLESEK TSTLLQTLDF IPRQAQKTLI FTCSAAETET
VCKVVESSSV FCLKMHKEMV FNLKSVLEQW KELSAGSHIV LALTDDCIPL LAVTDATCVI
HFSFPSSPKI FGGRLYCMSD HFQSLTEQGS AVEQGDKKTK SVLLLTERNA CHAVGVLRYL
ERADAKIPSE LYEFTAGVLE AKEEKKAKRP LCPYLKAFGF CKDKRICLDR HYINPEIDMP
RKLSNQALPV FGYVKMIPFY ILNATNYFGR IIDKHVDLYE ALNAEMTKYF KDSSNKTIVE
KVEKFGLYGL AEKTHFHRVQ VLEMSQEEDS WTLDNVLVKF IDEGRTGLVT RDQLLHLPEG
FRTLPPQAVE FIVCRVRPAD NEVEWNPKVT RYVHHKIIGK LHDAKVMLAL GNTVWIDPMV
HITKLSNLKT SVVDYNVRSE ILSMGMGVDN SEHIEQLRKL YKGATMPAFE ETLTPPRAED
AAALKNTGKE DGGSERGAHS GTNSENPEHE ALSENTEDTS INKSAQPDLK SFHPQIKWFQ
KDDVIILKIK IRNVKDYRCK YFRDRVVFSA WVGDRFYLAD MELQANIIKD DCRCIINNEE
PVITLAKERR ESWCSLLKRK NPNVAFDFDH WEECEEDSHF SKVVNSKSPP SKVAEVVENS
DKSSEDGKVR VSETVN
//
