ID A0A367L5J6_9HYPO Unreviewed; 1154 AA.
AC A0A367L5J6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=L249_3978 {ECO:0000313|EMBL:RCI09694.1};
OS Ophiocordyceps polyrhachis-furcata BCC 54312.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1330021 {ECO:0000313|EMBL:RCI09694.1, ECO:0000313|Proteomes:UP000253664};
RN [1] {ECO:0000313|EMBL:RCI09694.1, ECO:0000313|Proteomes:UP000253664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC 54312 {ECO:0000313|EMBL:RCI09694.1,
RC ECO:0000313|Proteomes:UP000253664};
RX PubMed=26511477; DOI=10.1186/s12864-015-2101-4;
RA Wichadakul D., Kobmoo N., Ingsriswang S., Tangphatsornruang S.,
RA Chantasingh D., Luangsa-ard J.J., Eurwilaichitr L.;
RT "Insights from the genome of Ophiocordyceps polyrhachis-furcata to
RT pathogenicity and host specificity in insect fungi.";
RL BMC Genomics 16:881-881(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI09694.1}.
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DR EMBL; LKCN02000014; RCI09694.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367L5J6; -.
DR STRING; 1330021.A0A367L5J6; -.
DR Proteomes; UP000253664; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000253664}.
FT DOMAIN 190..261
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 499..663
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 688..861
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 77..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 129156 MW; 24CA17B817EE5248 CRC64;
MDDVSNLELL SLVSKVTSEL QNHAGTSDKT LAEFLIFQRV KSSSLEDFRK WLDTVKNPFP
ESFVNSLDRL VLTLHPKFKG NAKPSDGDEH RPSRTLEDKE KIFSGLALPD EKNGGGGGGD
AIDDTLAMLE GLESKTKTGP PSKKRRRSPE DDPTDRRNGH RGSRKARRHR SDARIDRSPE
PEVDETPQMH KIYKGHVTGI KDFGAFVSLH HVRGKVNGLV HVSRLSAGQR VSHPSDLLSK
GQQVFVKVFS IEGSRIGLSM KDVEQATGID LEPQSRFSTG ANMEALGGGK RRGFGENVPA
MPRDGVGPPT RQKKRMTSPE RWEIRQLIAS GVAKASDFPD LEEDYNATLR GDGELELEED
VDIEVRDEEP PFLAGQTKQS LELSPIRVVK APDGSMNRAA MAGSVIAKER KELKRQEADT
KEEPKENLSS QWLDPMADPD KRKFASDMRT ARMNPKPEEV PEWKKAVIPR GQSLGKRTNL
SIKEQRRQLP VYAFRSQLIQ AVKENQILIV VGETGSGKTT QLTQYLAEAG FAGKGGIIGC
TQPRRVAAMS VAKRVAEEVG CKLGDAVGYT IRFEDCTSPA TKIKYMTDGM LQREILMDPD
MRRYSVIMLD EAHERTISTD VLFALLKKAL KRRPDLKVIV TSATLDADKF SAYFNECPIF
TIPGRTFPVE ILYSREPESD YLDVALLTVM QIHLTEPKGD ILLFLTGQEE IDTACETLFD
RKKALGPSVP DLIILPVYSQ LPTEMQTRIF EPAPPGSRKV VIATNIAETS ITIDEIYYVV
DPGFVKQNAY DPKLGMDSLV VTPISQAQAN QRAGRAGRTG PGKCFRLYTE AAYQSEMLPT
TIPEIQRQNL AHTILMLKAM GINDLLHFDF MDPPPVNSML TALEELYALS ALDDEGLLTR
LGRKMADFPM EPSLAKVLIA AVDRNCSDEM LSLVAMLNVP TIFYRPKDKQ QQADQKKAKF
HDPHGDHLTL LNVYNAWKRS GFSNPWCHEN FIQARSMRRA KDVRDQLLKI MDRYRHPVVS
CGRDTQKLRR ALCSGFFRNA ARKDPQEGYK TLIEGTPVYL HPSSALFGKH AEWVVYHTLV
LTTKEYMHCT TSIEPKWLVE AAPTFFKVAP SDRMSKRKQA ERIQPLYNRF AGENDWRLSA
QRRGGRGGGG STWG
//
