ID   A0A369SCD0_9METZ        Unreviewed;       696 AA.
AC   A0A369SCD0;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=TrispH2_003846 {ECO:0000313|EMBL:RDD44132.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD44132.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD44132.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD44132.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD44132.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD44132.1}.
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DR   EMBL; NOWV01000029; RDD44132.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369SCD0; -.
DR   STRING; 287889.A0A369SCD0; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd17980; DEXHc_DHX35; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:RDD44132.1};
KW   Helicase {ECO:0000313|EMBL:RDD44132.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000313|EMBL:RDD44132.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT   DOMAIN          61..226
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          258..431
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   696 AA;  79147 MW;  5BFE1A657507CEFC CRC64;
     MSDFTFKPKF LRPGANESDE IERREVSQGA GECIHYNRFM TLPLTQQRQR LPVFQYRNHI
     LYMLEKYSTL VVVGETGCGK STQIPQYLHE SGWSKGGRVI CVTQPRRIAT VTVATRVAEE
     QGVYLGREVG YAIRFEDCTD KTLTRIKFVT DGLLIREMMA DPLLRRYSVV MLDEAHERTI
     NTDVVIGLLK KIQKKRPELK IIISSATLDA EAFRDFFNSN TTDDTSLDTA SILSIEGRMF
     PVDIHYTADP VPDYIKAAVD TVFKIHQNEK RGDILVFLTG QEEVETAVNM TNDYNHQLQQ
     KLMPLPMYGG LPPGEQLKVF KKTPENMRKV IYATNIAEAS ITIDGVVYVV DCGFVKLKMV
     LPNAGMESLV IVPISKASAK QRAGRAGRVR SGKAYRLLTE KDYEKLLSSA TVPEMQRVNL
     SAVVIQLKAL GIDNVLRFDF LSPPPAKNMI RSLELLYALE ALDDYGRLTL GCGNKMAELP
     VDPMLGKMLL SSSKLECSEE ILTITAMLQV QNIFYTPPKR KAASDNARRK FAVYEGDHLT
     LLNVYKAFMR CRKSSKWCQE NYLNYKALTK AVAIRERLKV FMKKFKLPLI SCDDDPEAVC
     KCLVTGFFAN AAKYCGDGCY RTIRDNHVLH IHPNSVLYTE EPPKWVIFHE VLQTKKDYMR
     DITVIEPSWL YELAPHYYEY GTDLSRRKRK ADESNA
//