ID   A0A3B0KVY0_DROGU        Unreviewed;       628 AA.
AC   A0A3B0KVY0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=DGUA_6G020924 {ECO:0000313|EMBL:SPP90036.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP90036.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX4/VASA
CC       subfamily. {ECO:0000256|ARBA:ARBA00010132}.
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DR   EMBL; OUUW01000052; SPP90036.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0KVY0; -.
DR   STRING; 7266.A0A3B0KVY0; -.
DR   OMA; DVPDWLV; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd18787; SF2_C_DEAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR   PANTHER; PTHR47958:SF11; RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000492}.
FT   DOMAIN          244..421
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          445..592
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          129..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  70415 MW;  777C9A1D7A51FCCA CRC64;
     MAYIAQHTDM LRVMVDHQKY LSDQQHPGEA IRQYRSLAAV ETYDPHIILD MPISKVELVH
     GLFEALITWP RVDLQNAPFI KNRMDAARTF RFLLDLQATG IVKLSDKGRF CEGRRGCFNP
     YLGELGDRGD RGYRSERKER RRRNNDDEDD LNNNKGDEDG EDGEKKREFY IPPEPSTDEA
     EIFGTTISSG INFSKYDHIP VKVSGIDPPA AFQKFEDAKL RDIIAANVTK SGYKLATPIQ
     KVAIPVITAG RDLMACAQTG SGKTASFLLP ILTKLLDDAT DLEIGKPQAV IVSPTRELAI
     QIYHEARKFS YESYLKISIL YGGTSVKYQN ESIMMGCHVL IGTPGRLLDF VERAFITFDD
     TRFLVMDEAD RMLDMGFSES MRKIVNHCTM RAEHQTLMFS ATFPEEIQRM AGEFLNNYVF
     VTIGVVGGAC SDVKQTIYEA TKFNKRSKLM EMLKESADGT IVFVETKRGA DFLASYLSET
     EIPTTSIHGD RLQSQREQAL RDFKSGRMKI LIATSVASRG LDIKNVKHVV NYDMPRVIDD
     YVHRIGRTGR VGNNGRATSF FDVEHDSAIA TDLVKILEGS EQQVPDFLRA LDRGYGGGGA
     SQFGGYDVRG SGNALKDVCA VEEDQDWA
//