ID A0A3B3B7P7_ORYME Unreviewed; 1187 AA.
AC A0A3B3B7P7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 9 {ECO:0000256|ARBA:ARBA00031576};
DE AltName: Full=Nuclear DNA helicase II {ECO:0000256|ARBA:ARBA00033216};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000001580.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000001580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR AlphaFoldDB; A0A3B3B7P7; -.
DR STRING; 30732.ENSOMEP00000001580; -.
DR PaxDb; 30732-ENSOMEP00000001580; -.
DR Ensembl; ENSOMET00000014023.1; ENSOMEP00000001580.1; ENSOMEG00000002437.1.
DR GeneTree; ENSGT00940000155924; -.
DR OMA; RFKCELR; -.
DR Proteomes; UP000261560; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0033679; F:3'-5' DNA/RNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW.
DR CDD; cd17972; DEXHc_DHX9; 1.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044447; DHX9_DEXHc.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Transcription {ECO:0000256|ARBA:ARBA00022472};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00022472};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472}.
FT DOMAIN 3..71
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 191..263
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 409..575
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 649..819
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1158..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 133048 MW; 55E3B76B8993D73B CRC64;
MADIKNFLYA WCGKKKLTPN YDIRAAGNKN RQKFMCEVRV DGFNYVGMGN STSKKDAQTN
AARDFVNYLV RVGEMKAEEV PALGVMAPEP TQPDGPPGSF GTLPASGPLP PHLVVKGEKE
AEVPMEEHAG QTEQGYPPRG GYGDGGGAEW DRGANLKEYY ARRDEQEAQA TLESEEVDLN
ANLHGNWTLE NAKARLNRFF QQEKMTAEYK YSQVGPDHNR SFIAEMQLFV RQLGRKIMAR
EHGSNKKLAA QSCALSVVRQ LYHLGVLEAY TGITKKKEGE TLEPYDVNVS PDLQQQLNTV
VEELGIQVPP PPEDPSNPVS LIQGKINTFE PSQRQNTAGV VPWSPPQVNW NPWTSSNIDE
GPLAFCTPEQ ISEDLHNELM YQLEHDDSLQ KILAERDQLP VKQFEEEIMG ALESNPVVII
RGATGCGKTT QVPQYILDRF IKGGRASDCN IVVTQPRRIS AVSVAERVAY ERAEDLGKSC
GYSVRFESVL PRPHASILFC TVGVLLRKLE AGIRGISHVI VDEIHERDIN TDFLMVVLRD
VVQAFPDVRI LLMSATIDTT MFREYFFNCP IIEVFGRTFP VQEYFLEDCI QMTNFIPPPM
DRKKKAKDEE GGEEDTNCNL ICGAEYTPET KNTMSQMSEK ETSFELVEAL LKYIETLKVA
GAVLVFLPGW NLIFSMQRHL ETNPHFGSNR YRILPLHSQV PREEQRRVFE PVPDDVTKVI
LSTNIAETSI TINDVVYVID SCKQKVKLFT SHNNMTNYAT VWASKTNLEQ RKGRAGRVRP
GFCFHMCSRA RFEKLETHMT PEIFRTPLHE VALSIKLLRL GSIGHFLSKA IEPPPLDAVI
EAEHTLRELD ALDSNDELTP LGRILARLPI EPRLGKMMIM GCIFNVGDAV CTISAASCFP
EPFISDGKRL GFVHRNFSGS RFSDHVALLA VFQAWDDVRV NGEEAEMRFC EHKRLNMATL
RMTWEAKVQL KEILVNSGFP EECLMTQMFN TVGPDNNLDV VISLITFGSY PNVCYHKEKR
KILTTEGRNA LIHKSSVNCP FSSHDIKYPS PFFVFSEKIR TRAISAKGMT LVSPLQLLLF
ACKKISSNGE IVELDDWIKL RIPHEVAGGV AALRAGLEAL VVEVTKDPEY INQMDQGNTR
MLNAIRYVSK PTAAGLNLMN SSQRMGDGPR PPKMARFDGG GNRGGGF
//
