ID   A0A3B3CSD5_ORYME        Unreviewed;      1024 AA.
AC   A0A3B3CSD5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Oryzias melastigma (Marine medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000020019.1, ECO:0000313|Proteomes:UP000261560};
RN   [1] {ECO:0000313|Ensembl:ENSOMEP00000020019.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   AlphaFoldDB; A0A3B3CSD5; -.
DR   STRING; 30732.ENSOMEP00000020019; -.
DR   PaxDb; 30732-ENSOMEP00000020019; -.
DR   Ensembl; ENSOMET00000029385.1; ENSOMEP00000020019.1; ENSOMEG00000021862.1.
DR   GeneTree; ENSGT00420000029847; -.
DR   OMA; KMHKEVV; -.
DR   Proteomes; UP000261560; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd20435; Tudor_TDRD12_rpt2; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 2.40.50.90; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   PANTHER; PTHR22655:SF2; ATP-DEPENDENT RNA HELICASE TDRD12-RELATED; 1.
DR   PANTHER; PTHR22655; UNCHARACTERIZED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00567; TUDOR; 2.
DR   SMART; SM00333; TUDOR; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          72..133
FT                   /note="Tudor"
FT                   /evidence="ECO:0000259|SMART:SM00333"
FT   DOMAIN          848..909
FT                   /note="Tudor"
FT                   /evidence="ECO:0000259|SMART:SM00333"
FT   REGION          303..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1024 AA;  115374 MW;  966D7461360DAD0F CRC64;
     MILLGTESFI LKISIKTPHI LRDIESPSCL WCRVIQEPGV DTETAEQYSK LQARMNLFYN
     DLTQDQSRLI PTSFEENEVY AVFWEERKFW CRVVVKSITV DSVTCLACCF LVDYGERIVV
     SSDKIRLTVP DFLQLPFWAQ KFHLSGIKPT TLRVPFLEEK AELIPSSQWD ISATLYLHSL
     LKASLSMEAV LLESESDSTA IELYLSTGDF KICVNDELVS KKFAYYSEES GRGGLDPWGR
     IPVKFCSILT QIDSASSIKL EAVKPPPTSG KHTFESPVPR VGLDEELNMC RPVQKNKHST
     TFLEWLNPGP SNPDQEDSDD AAPHCDPCLS GVLVHSSLPV EACSSLEDAP VTYPLRRVNL
     HVVKYGSLSS ADCYSWPAVA QGNSTVIISH SSDQPLSFLA PILTHILLNS LYTPRMSSLG
     PMVLVLCPGW ERVQMVFSVL EETKVSESLH PDVALLGVGK DQAKNFKLPK NCLMLVTTPF
     TMVRLLSCHC RLFQRLYHLV LDEADQLFAR APDQMKTILQ HFHKVVSTEE KTLYPQQLVC
     VAKRWSPQME AMVTAYMPYP SIVITIPEEA GLYGNVQQIV LMTVESMKIS VLMGVLDFSP
     LVCQKTLIIA NSSQDVDYVY EVIHSKSAFC LKTHEGLTHQ FDSVVQQWSK DIGAGSHLIL
     VTTDECLKCL GIRDATCVVH YEFPAARKWF GRRLFCMFKN FRNLSKQTQR CSSVARSVLL
     VSEKDSRHIV GVMRYLRRTD ALLPPELLAF EQGVLKARDE QKMSRPLCSY LKSFGVCRDS
     SVCPDRHTFS PLLDRSTLPA AGIIEVVPLF IKTASVFCGR LVRKEDREFD EMVSGMASYY
     ADKKPEARDL QEGGLYAVQE EDFFHRVKIL SLPKSDGSLF FCVYVRFIDV GREKEVKSYQ
     ILKLPEHFHS LPEQAVEITV CGVKPADAEI DWHPKVIRTI SQKIRGLQHR ATAVLSLGNT
     IFVDPMVRVT QVPGMKTLIN EYNVQLEILN TGMGFRNPDH LDLLKALCQD EKACSHKEDV
     HPSG
//