ID A0A3B4DR34_PYGNA Unreviewed; 1404 AA.
AC A0A3B4DR34;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(27) demethylase {ECO:0000256|ARBA:ARBA00034525};
DE EC=1.14.11.68 {ECO:0000256|ARBA:ARBA00034525};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000025419.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000025419.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-
CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224,
CC Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.68; Evidence={ECO:0000256|ARBA:ARBA00034421};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the UTX family. {ECO:0000256|ARBA:ARBA00034483}.
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DR RefSeq; XP_017568434.1; XM_017712945.1.
DR STRING; 42514.ENSPNAP00000025419; -.
DR Ensembl; ENSPNAT00000007666.1; ENSPNAP00000025419.1; ENSPNAG00000010594.1.
DR GeneID; 108436446; -.
DR CTD; 569207; -.
DR GeneTree; ENSGT00940000166518; -.
DR OMA; CENNRSH; -.
DR OrthoDB; 20251at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032452; F:histone demethylase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR Gene3D; 1.20.58.1370; -; 1.
DR Gene3D; 2.10.110.20; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR046941; KDM6_GATAL_sf.
DR InterPro; IPR048562; KDM6A_B-like_C-hel.
DR InterPro; IPR048560; KDM6A_B-like_GATAL.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14017; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR14017:SF9; LYSINE-SPECIFIC DEMETHYLASE 6A; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF21322; KDM6_C-hel; 1.
DR Pfam; PF21326; KDM6_GATAL; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 96..129
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 133..166
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 321..354
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1098..1261
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 438..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..941
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1404 AA; 153466 MW; A0F5ED88FD571233 CRC64;
MQSCRVSLAV AACAAARSLG AAGDEEKKMA AGKASETEED FPRLTAQERD SLAGIDSSLF
GFLRLHEDGA RTKALLLKAV RCYDSLILKA EGKVDPELFC QLGHFNLLLE DYPKALSAYQ
RYYSLQSDYW KNAAFLYGLG MVYFHYNAFQ WAIKAFQEVL YIDPGFSRAK EIHLRLGLMF
KVNTDYESSL KHFQLALIDS NHCTLSKAEI QFHIAHLYEI QKRYRAAKEA YESLLKTENL
PAQVKAATLQ QLGWMHHTVE QLGDRSNKDS YAIQCLQKSL EADPNSGQSW YFLGRCYSSI
GKVQDAFISY RQSIDKSEAS ADTWCSIGVL YQQQNQPMDA LQAYICAVQL DHSHAAAWMD
LGTLYESCNQ PQDAIKCYIN ATRSKGCSNT AALTARIKYL QAQLCNLQHT SLQSKSKMLP
SIEEAWSLPI PAELTSRQGV QNTAQQACKP HPSAGGGLTG AHGSGQSLPP HVSPLGHGEE
QSSPAKRKRT SSPAKSSAEW GSSPAQQTPS WYLSPQKLQL LEQLRANKAN LKPVQMQRLE
QLEAQLSAMQ LHQQQMRQNA SGQVRPTLPN GPTAGPSLPV QIHSRGPAVR PPCTAQPLAN
GPFSASPSSV PRTGPHPSSV GNNHMPGTGT NGDVPYLHPN ALPHNCTSPS DTWKSQHLNS
TQGLQKGSHW AGPNGDRALS SSASADGGPH NQVGHSSTTH VDPSEPAVNH LSSPTPSSAS
SPASSSVHTA TSGAPLTKES DHPQGNGSTA ANHHSPSHTP TSTSTSGSPA THSSDNPQLS
ALLACKESPA TGPRVNHIHP AVTLPAPGSS AASSPASALS TTSPSPRANE LTASLNKPGS
TTPGPPPAVT VNGSGGGVCS EDSQSPLKAE PPEVCLKPAP PHRPSHSSST VSIYPTSSDI
LKACRNLGKN GLSSSSILLD KCPPPRLPPP PSPPLPKDKL NPPTPSIYLE NKRDAFFPPL
HQFCTNPSNP VTVIRGLAGA LKLDLGLFST KTLVEANPEH LVEVRTQLCQ PADENWDTSG
TRKQWRCESS RSLTTIAKYA QYQAASFQES LREENEKKGQ KELSDSEMSS SENVARRRKG
PFKQIKFGTN IDVSDEKKWK LQLQELSKLP AFARVVSAGN LLSHVGHTIL GMNTVQLFMK
VPGCRTPGHQ ENNNFCSVNI NIGPGDCEWF AVPEPYWGVM SEFCEKNNIN FLMGSWWPNL
EDLYEANVPV YRFIQRPGDL VWLNTGTVHW VQAIGWCNNI SWNVGPLTAH QYKLAVERYE
WNKLQSVKSA VPMVHLSWNM ARNIKVSDHK LFEMIKFCLL RTLKQCQTVK ESLVASGKET
IWHGRSRDEP ARYCTICEVE VFNLLFVTSE SYSRKTFVVH CQDCARKGSS DLDGFVVLEQ
YRMEDLMQVY DQFSLAPPLH SSSS
//
