ID A0A3B6FQ41_WHEAT Unreviewed; 1195 AA.
AC A0A3B6FQ41;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=CFC21_042341 {ECO:0000313|EMBL:KAF7030904.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3B02G337600.3};
RN [1] {ECO:0000313|EMBL:KAF7030904.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7030904.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3B02G337600.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G337600.3};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G337600.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7030904.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7030904.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; CM022218; KAF7030904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6FQ41; -.
DR SMR; A0A3B6FQ41; -.
DR STRING; 4565.A0A3B6FQ41; -.
DR PaxDb; 4565-Traes_3B_5D41CB402-1; -.
DR EnsemblPlants; TraesCS3B02G337600.3; TraesCS3B02G337600.3; TraesCS3B02G337600.
DR Gramene; TraesCS3B02G337600.3; TraesCS3B02G337600.3; TraesCS3B02G337600.
DR Gramene; TraesCS3B03G0857800.2; TraesCS3B03G0857800.2.CDS; TraesCS3B03G0857800.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 25..88
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 196..373
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 456..488
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 543..716
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 994..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 130936 MW; 7DF3042199A7946F CRC64;
MGRKGPKGAK NAAALTKAAL AAMSEETTVR ITTLLEDFRA SDAQVHTFEP SLTNQERAAV
HAMCKKMGMI SKSKGYGERR CLSVYKTKNT QGAVKEEGPS KLGFSEEARQ VLLDLFTHYP
PDDAELNGDA VKNPGDKAAK ILWKTDTAFS RPAMQKHDIA KKVKMLTSKL NDTRQLRKIG
EGRSKLPIAS FKDHISSTLE NHQVVLISGE TGCGKTTQVP QYILDHVWGK GESCKIICTQ
PRRISAMSVA ERISVERGET VGDTVGYKIR LESKGGKNSS IMFCTNGVLL RVLIGRVTNI
SKRQRAADDV IMGITHIIVD EIHERDRFSD FMLAILRDLL PIYPHLHLVL MSATIDAERF
SQYFNGCPVI QVPGHTYPVK TFYLEDVLSI LQSVGDNHLN PETNDLGLDS VLTDDYKSSM
DEAISIALVS DEFDPLIELI SIEQNPEIFN YQHSETGVTP LMVFARKGQL GDVCMLLSFG
VDCSARDHDG KSALDWAQQE NQVEAYEVIK KHMDCSPAKL PEENELLKKY LATINPEHID
TVLIERLLRK ICTDSNEGAI LVFLPGWEDI NQTRERLLAS SFRDSSKFLV LSLHSMIPSS
EQKKVFKRAP AGVRKIILST NIAETAVTID DVVFVIDSGR MKEKSYDPYN NVSTLHTSWV
SRANARQREG RAGRCQPGTC YHLYSRFRAA SLPEFQIPEI KRMPIEELCL QVKLLDPNSK
IADFLKKTLD PPVTETVKNA ITVLQDLGAL TQNEQLTDLG EKLGSLPVHP STSKMLLFGI
LMNCLDPALT LACAADYRDP FVLPMAPDER KRAAAAKVEL ASLYGGYSDQ LAVVAAFDCW
TCAKVKGQEA LFCSKYFVAS NTMNMLSSMR KQLHSELTQR GFLPADTSAC SLNAKVPGII
SAVLVAGAYP MVGRLLPPRK NARRAVLETA SGAKVRLHPH SSNFNLSFNK SSGNPLMVFD
EITRGDGGMY VKNCSVVGSY PLLLLATEIA VAPPDDVSDE DDEGSSGDEA GKSTLGQQKE
EIMSSPDNTV SVVVDRWLRF DATALDVAQI YCLRERLASA ILFKVKHPQD VLPPALGATM
YAIACILSYD GLPGNLATRH GSGQSSTDAS GSAEGRKVGF IPPGGFLMSL LSDVPPNAPH
HQKSSNHPGG GSGHIRSSRA PAGRFNQSQQ HPGRNSSGPG SSASQSFKRQ RDAAR
//
