ID A0A3P6U599_LITSI Unreviewed; 658 AA.
AC A0A3P6U599;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=NLS_LOCUS2063 {ECO:0000313|EMBL:VDK73314.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK73314.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK73314.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; UYRX01000087; VDK73314.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6U599; -.
DR STRING; 42156.A0A3P6U599; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT DOMAIN 17..158
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 183..357
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 658 AA; 74053 MW; 2CE39B361D04204C CRC64;
MYVNVEKSDY IISLTKLTTL KYTATVALVI ATIEHYQICY DEGLICGGLV AVTEPRRVAA
ITLARRVALE MNANLGEVVA YKVRFENTTS DETKIVYGTD GIFLRETFYD SLLTHYSLVI
VDEAHERSVH TDIVIMSATL ETNIFSEYFD DAPVYIVQGR TYPVEIFYAN SLDKKDDDYV
FNVLTTVLQI HRTEPLSSDV LAFLTGQEEI ETACRKVQEA SKLVTGGLIA LPLYAGLPPS
AQMRVFEPTS VPYTRKIIFA TNIAETSITI PGVRIIVDSG KMKVKTFLPD RHIDILRVED
ISQCSATQRA GRAGREAPGK CYRLYSEKHF HSLSKVTVPE ILRSNLAVVL LELLRIGLRR
IKSLALISNP KKERLEAAEK HLRLLDAVKR PDKKGRLRLT EMGTALSSFP VDPAFARALI
AASQNECLEE VLTIVAFMST DSVFVSSASS REQTNLSRRK FEAPEGDHCT LLNVYRGYRL
ARKEKKLEEW CEANHVHHRL LNTVFKIRKQ LRDICSKNSM IFRSCGTDTD KLRKALCQGL
FMNACAYERL HDRYSLLISP GTLLKIHPSS CLSRSRPTAF IFTDLVRTNE LYARRQKWEN
DTAICHAVTR IIARSATTIF DAIVTVFDGV TCSPSFISAL KLSSIRAEFH FSGVSFVL
//
