ID A0A3Q3W480_MOLML Unreviewed; 1626 AA.
AC A0A3Q3W480;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(4) demethylase {ECO:0000256|ARBA:ARBA00012902};
DE EC=1.14.11.67 {ECO:0000256|ARBA:ARBA00012902};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000003259.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000003259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-
CC [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone
CC H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537,
CC Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67;
CC Evidence={ECO:0000256|ARBA:ARBA00000604};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the JARID1 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00006801}.
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DR STRING; 94237.ENSMMOP00000003259; -.
DR Ensembl; ENSMMOT00000003311.1; ENSMMOP00000003259.1; ENSMMOG00000002608.1.
DR OMA; GFDQVCK; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16873; ARID_KDM5A; 1.
DR CDD; cd15515; PHD1_KDM5A_like; 1.
DR CDD; cd15606; PHD2_KDM5A; 1.
DR CDD; cd15686; PHD3_KDM5A; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR048615; KDM5_C-hel.
DR InterPro; IPR047974; KDM5A_ARID.
DR InterPro; IPR047970; KDM5A_PHD2.
DR InterPro; IPR047972; KDM5A_PHD3.
DR InterPro; IPR013637; Lys_sp_deMease-like_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR004198; Znf_C5HC2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF17; LYSINE-SPECIFIC DEMETHYLASE 5A; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF21323; KDM5_C-hel; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF08429; PLU-1; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 13..54
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 78..168
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 228..278
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 372..538
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 1096..1156
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1531..1585
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1255..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1466..1507
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1626 AA; 185159 MW; 6C950F24F31F14F2 CRC64;
MSAFPEFVPP PECPVFEPSW EDFSDPLGFI NKIRPIAEKT GICKIRPPED WQPPFACDVR
NFRFTPRVQR LNELEALTRV KLNFLDQIAK FWELQGSKIR FPHVERKVLD LYQLSKTVSS
EGGFETVCKE KRWSKVASRM SYPQGKGTGS LLRSHYERIL YPYELFQSGA TLTVSGTEEN
KEPKGLKIFG TNPKMVGLEI VSRHLKAQAF AIKMRPRKET LEVNFIDLYL CLVCGRGDEE
DRLLLCDGCD DSYHTFCLIP PLQDVPKGDW RCPKCVAEEC SKPREAFGFE QAVREYSLQS
FGEMADQFKS DYFNMPVHMV PTELVEKEFW RLVSSIEEDV IVEYGADISS KDVGSGFPVR
DGKRRLLGDE EDYANSGWNL NNMPVLEQSV LTHINVDISG MKVPWLYVGM CFSSFCWHIE
DHWSYSINFL HWGEPKTWYG VPASAAEQLE AVMKKLAPEL FDSQPDLLHQ LVTIMNPNVL
MEHGVPVYRT NQCAGEFVVT FPRAYHSGFN QGYNFAEAVN FCTADWLPMG RQCVAHYRRL
HRYCVFSHEE LLCKMAADPE SLDVELAAAV LKEMGEMMEE ETKLRGAVQG LGVLSSEQEV
FELLPDDERQ CHKCKTTCFL SALTCSCSPD RLVCLHHAAD LCDCPLGNKC LRYRYDLEEF
PSMLYGVKTR AQSYDTWSKR VTEALAADQK NKKDLIELKV LLEDAEDRKY PEKALFRRLR
EIVKEAETCS SVAQLLLSRK QRHSRLRSES SCNRTKLTVD ELKAFVDQLY RLPCIISQAR
QVKELLENVE DFHERAQVAL SDEMPDSSKL QALLDLGSGL DVELPELPRL KQELQQARWL
DEVRVTLAEP QRFTLELMKR LIDSGVGLAP HHAVEKAMAE LQEILTVSER WEDKARACLQ
ARPRHSMVTL ESIVLEARNI PAYLPNILAL REALQKAKEW TAKVEAIQSG SSYAYLEQLE
SLLARGRSIP VRLDPLAQVE SQVAAARAWR ERTARTFLKK NSTYTLLQVL SPRVDIGVYG
NSKSKRKRVK ELMEKERGGF DPDALSDLED CLEEVRDPST VVAAFKAKEQ KEVESIHSLR
AANLAKMAMA DRIEEVKFCL CRKTASGFML QCELCKDWFH GACVPLPKTG SQKKLGVGWQ
SNSKDSKFLC PLCQRSRRPR LETILSLLVS LQKLPVRLPE GEALQCLTER VMSWQDQARQ
ALATEELSSA LAKLSVLSQR MVEQAAREKT EKIINAELQK AAANPDLQGH IQTFQQSGFS
RATSPRQSLD YDDEETDSDE DIRETYGYDM KDPGEVKPYL FCDEEIPVKS EEVVSHMWPA
ATPSFCAEHA YSSASKSCVQ NISTPRKQPR KTPLVPRSLE PPVLELSPQA KAQLEELMML
GDLLEVSLDE TQHIWRILQA THPPSEERFL QVMEPDDSLM EKPLKIKIKD SEKKRKRKLE
RAEHHHMVGL ELVLGGKSKK KKLKLNMDKN REMKQLAKRL AKEEKERKRK EKAAAKAEAI
REGLEKRKEK KILDIPSKYD WSGAEDSNDE NAVCAAKNCQ RPCKDKVDWV QCDGGCDEWF
HQVCVGVSCE MAENEDYICM DCSRKAAGVS AGGAIKSNQI PLSSLNSYTT KFKPCRGYCF
PPFVYN
//
