ID A0A3Q7S4B6_VULVU Unreviewed; 4989 AA.
AC A0A3Q7S4B6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|RefSeq:XP_025849541.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025849541.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025849541.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025849541.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025849541.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025849541.1; XM_025993756.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50216; DHHC; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 228..332
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 342..392
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 345..390
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 389..439
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 465..521
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 955..1008
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1005..1055
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1082..1137
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4477..4585
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4849..4965
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4973..4989
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1404..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..2475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2591..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2816..2894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2952..2979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3030..3053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3229..3255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3302..3341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3354..3443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3461..3607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3619..3834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3848..3902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4047..4087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4104..4129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1484..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1885..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1940..1986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2015..2029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2057..2079
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2133..2152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2161..2180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2181..2202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2227..2250
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2299..2317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2324..2400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2410..2424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2453..2475
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2639..2670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2679..2706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2707..2724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2816..2833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2841..2857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2858..2872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2960..2979
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3315..3337
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3380..3394
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3398..3412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3425..3443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3497..3574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3589..3607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3646..3674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3688..3728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3851..3866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3867..3902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4989 AA; 548931 MW; F5B475171F5E43CE CRC64;
MSSEEDKSAE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSKGK
TTVEDEDSMD GLETTETENI VETAEIKEQS AEEDAEAEVD NSKRPIPVLQ RSVSEESASS
LVSVGVEAKI SEQLCAFCYC GEKSSLGQGD LKQFRVTPGF ILPWKSQPSN KKDVDDNSNG
TCERIQNSAP RKQRGQRKER SPLQNIVSCV SVSTQTASDD QAGKLWDELS LVGLPDAIDV
QALFDPTGTC WAHHRCVEWS LGVCQMEEPL LVNVDKAVVS GSTERCAFCK HLGATIKCCE
EKCTQIYHYP CAAGAGTFQD FRNFFLLCPE HIDQAPERSK EDANCAVCDS PGDLLDQFFC
TTCGQHYHGM CLDIAVTPLK RAGWQCPECK VCQNCKQSGE DSKMLVCDTC DKGYHTFCLQ
PVMKSVPTNG WKCKNCRICV ECGTRSSSQW HHNCLVCDSC YQQQDNLCPF CGKCYHPELQ
KDMLHCNMCK RWVHLECDKP TDHELDSQFK EEYICMYCKH IAAEMDPLQA GDEVVMAEVT
TDYNNEMEVE GPEDHMVFPE QAINKDISDQ ESTPGIVPDA VHILTEEQQQ NNTPESLDTH
GLLISESSQD KMNPEVENQI SHEVDSEKME MSSKVMHICE DQNENKMEVT ENIEVRTHQI
IVPHEDLQLE ESKMLASIEE SRPPKSATES AIVPPDTVVS PCEQSTSLCS KEQLVIERVQ
EEMEQKARSE SSTAFTDFGM APAVENCVKD GLCREDKPVK LPSETELSFV SAADISKANV
SSSPLSSDLP SQDILHTYPS TLSASVGNIM PTTYISVTPK IGMGKPAITK RKFSPGRPRS
KQGAWSTHNT VSPPSWSPDI SEGREIFKPR QLPGSAIWSI KVGRGSGFPG KRRPRGAGLS
GRGGRGRSKL KSGIGAVVLP GVSATDVSSN KDEEENSMHN TVVLFSSSDK FTLHQDMCVV
CGSFGQGAEG RLLACSQCGQ CYHPYCVSIK ITKVVLSKGW RCLECTVCEA CGKASDPGRL
LLCDDCDISY HTYCLAPPLQ TVPKGGWKCK WCVWCRHCGA TSAGLRCEWQ NNYTQCAPCA
SLSSCPVCCR NYREDDLILQ CRQCDRWMHA VCQNLNTEEE VENVADIGFD CSMCRPYMPT
SNVPSSDCCE SSLVAQIVTK VKELDPPKTY TQDGVCLTES GMTQLQSLTV TVPRRKRSKP
KLKLKIINQN SVAVLQTPPD IQSEHSRDGE MDDSREGELL DCDGKSESSP EREAVDDETK
GVEGTDGVKK RKRKPYRPGI GGFMVRQRSR TGQGKTKRSV IRKDSSGSIS EQLPNRDDGW
SEHLPDTLVD ESVSVTENTE KIKKRYRKRK NKLEETFPAY LQEAFFGKDL LDTSRQNKLS
LDNLSEDTAH LSYKTNMNTN FLDPSLDPLL SSSSTPAKPG PHGTTDDPLA DISEVLNTDD
DILGIISDDL AKSVDHSGLD LCTFQVESSP FPFAGIDIGP VTDDPSSLPQ SSVNPSSRPL
SEEQLDGILS PELDKMVTDG AILGKLYKIP ELGGKDVEDL FTAVLSPTAT QPPPPPTPQL
LPMHSQGMSP LEKFHVFSRM PLMNGLIGPS PHLPHNSLPP GSGLGTFSAI AQSPYTDARD
KNPAFNPMAS DANSAWTSSA PAVEGENDTM SNAQRSALKW EKEEALGEMA TVAPVLYTNI
NFPNLKEEFP DWTTRVKQIA KLWRKASSQE RAPYVQKARD NRAALRINKV QMSNDPLKRQ
QQQDSIDPGS RIDSDLFKDP LKQRESEHEQ EWKFRQQMRQ KSKQQAKIEA TQKLEQVKNE
QQQQQQQQQF GAQPLLAQSG SDTPSSGMQS PLTPQPGNGN VSPAQSFHKD LFTKQLPSTP
TSASSDDVFV KPQAPPPAAT PSRVSIQEGL PQSQACQPAS PQVFSPGSSH SRPPSPMDPY
AKMVGTPRPP PGGHSFSRRN SAAPADSCTP LPSVSRPAQM TDTTANRPSP VRDLCSSSTT
NTDPYAKPPD TPRPMMTDQF PKPLGLPRSP IVSEQTAKGP LTAGTNDHFT KPSPRADVFQ
RQRIPDPYAR PLLTPAPLDS GPGPFKTPMQ PPPSSQDPYG SVSQPPRRLS VDPYERPALT
PRPVDNFSHN QSSDPYSQPP LTPHPAMNES FAHPSRAFSQ PGTISRPTSQ DPYSQPPGTP
RPVVDSYSQP SGTSRSNPDP YSQPPGTPRP TTIDPYSQQP PTPRPSAQAD LFVTSVTNQR
HSDPYGHPPG TPRPGISVPY SQPPATPRPR ISEGFPRSSM TRPVLMPNQD PFLQAAQTRG
AALSGPLIRP PDACSQTPRP PGPSLSDTFT RVSPSATRDP YDQPPMTPRS QSDSFGTSQV
SHDIVDQSRP GSEGSFSAPS NSPMSSQSQQ FSSVSHLPGP IPTSGVTDTQ NTVNMSQADT
EKLRQRQKLR EIILQQQQQK KMAGRQEKGS QDPAAVPHPA PLQHWQPESI SQAFTRPPPP
YPGNIRSPVG PPLGPRYAVF PKDPRGPYPP DVTGMGMRPH GFRFGFPGAS HGTLSSQERF
LVPPQQIQGS GVPPQLRRSI SVDMPRPLNN SQMNNPVGLP QHFPPQSLPV QQHNILGQAF
IELRHRAPDG RPRLPFSASP SSVIEAPSHP RHGNFIPRPD FPGPRHTEPL RRPSQGLPTQ
LPLHPNLEQV PPSQQDQGHP AHSSSMVMRS LNHPVGGEFS EASLSTSTSA ETTSDNLQMT
TQSSEGLEEK LDSDDPSVKE LDVKDLEGVE VKDLDDEDLE NLNLDTEDGK GDELDTLGNL
ETNDPNLDDL LRSGEFDIIA YTDPELDLGD KKSMFNEELD LNVPIDDKID NQCVSIEPKK
KEQEEKTMVP PDKHSPWKKS VGTSEIKTEV LSPNSKGETK CESEKSEESK DNVDTPCSQA
SAHTDINDGE KAPLQSCDTD LLEKRTNRET AVSSTSGVLG STQLPAEDVI NSCGITGTTP
VLSSLLANEK SDNSDIRPLG SPPPTLPASP SNHVSNLPPP LLTPPGHVLD NTINSNVTVV
SRVNHTFPQG VQVNPGFIQG QSTVNHGFGT GKPTNQTVPL TSQSGTSGMS GPQQLMIPQT
LAQQNRERPL LLEEQPLLLQ DLLDQERQEQ QQQRQMQAMI RQRSEPFFPN IDFDAITDPI
MKAKMVALKG INKVMAQNNM GMPPMVMNRF PFMGQSVTGT QTSEGQSLLP QAIAQDGSIT
HQISRPNPPN FGPGFVNDSQ RKQYEEWLQE TQQLLQMQQK YLEEQIGAHR KSKKALSAKQ
RTAKKAGREF PEEDAEQLKH VTEQQSMVQK QLEQIRKQQK EHAELIKDYR IKQQQQQQQQ
QQQQQQCALA PPAVMPGVQP QPPLVPGATP PAMSQPSFPM VPQQLQHQQH PAVISGHSSP
ARMPSLPGWQ PASAPAHLPL NPARIPPPVA QLPIRTCTPA PGTVSSVNPQ SGPPPRVEFD
DNNPFSESFQ ERERKERLRE QQERQRIQLM QEVDRQRALQ QGVGMQQHGP LRSQMPFYGS
DLPCDFTQPP RPLQQSPQPQ QQMGQGSQQQ SIQQGSMNSP PTQTFLQTNE RRQIGPPSFL
SDSPSIPGGS PNFHSVKQVH GGLSGTSFQQ SPVRPPFTPA LPAAPVATNS SLPCGQDPAA
THGQSYPGSA QSLIQLYSDI IPEEKGKKKR TRKKKKDEDV ESTRAPSTPH SDITAPPTPS
ISETTSTPTV NTPGELPPQV EPESMEPVCP STPNTAAGQL GTELENKLPQ TDLSQGTPNP
QTYANPEVDK LSMETPAAAE EVKVETAEPQ QCPGQDGPDR EEQTGNEAEG RAVAGPVSSA
QSPPHSAGAP AAKGDSGNEL LKHLLKNKKS SSLLSQKPEG SFSEDDCTKD NKLVERQNPV
EGLQTLGAQM QGGFGCGNNQ LPKTDGGSET KKPRSKRTQR TGEKAAPRSK KRKKDEEEKQ
AMYSTTDTFT HLKQLSLLPL MEPIIGVNFA HFLPYGSGQF NSGSRLLGTF GSATLEGVSD
YYSQLIYKQN NLSNPPTPPA SLPPTPPPMA CQKMANGFAT TEELAGRAGV LMSHEVTKSL
GPKPFQLPFR PQDDLLARAI AQGPKTVDVP ASLPTPPHNN QEELRIQDHG GDRDTPDSFV
PSSSPESVVG MEVSRYPDLS LVKEEPPEPV PSPIIPILPS SAGKGLESRR NDIKTEPGTL
FFTPPFGSSP NGPRSGLISV AITLHPTAAE NISSVVAAFS DLLHVRIPNS YEVSNAPDVP
SMGLVSSHRV NPGLECRQHL FLRGPPPGPA NPPRLASSYR LKQPDGPFPP TSNGFSGYKD
PSHGIAESTA LRPQWCCHCK VVILGSGVRK SFRDLAFVSK DSRESSNRME KDIVFCSNNC
FVLYASTTQA KNSESKESAP PMMQSPVKEM PSKAFHQYSN NISTLDVHCL PQLQEEVSPP
ASPPITFPPA FEAAKVEAKP DELKVTVKLK PRLRTVHGGF EDCRPINKKW RGMKWKKWSI
HIVIPKGSFK PPCEDEIDEF LKKLGTSLKP DPVPKDYRKC CFCHEEGDGL TDGPARLLNL
DLDLWVHLNC ALWSTEVYET QAGALINVEL ALRRGLQMKC VFCHKMGATS GCHRFRCTNI
YHFTCAIKAQ CMFFKDKTML CPMHKPKGIH EQELSYFAVF RRVYVQRDEV RQIASIVQRG
ERDHTFRVGS LIFHTIGQLL PQQMQAFHSP KALFPVGYEA SRLYWSTRYA NRRCRYLCSI
EEKDGRPVFV IRIVEQGHED LVLSDSSPKG VWDKILEPVA CVRKQSEMLQ LFPAYLKGED
LFGLTVSAVA RIAESLPGVE ACENYTFRYG RNPLMELPLA VNPTGCARSE PKMSAHVKRF
VLRPHTLNST STSKSFQSTV TGELNAPYSK QFVHSKSSQY RKMKTEWKSN VYLARSRIQG
LGLYAARDIE KHTMVIEYIG TIIRNEVANR KEKLYESQNR GVYMFRMDND HVIDATLTGG
PARYINHSCA PNCVAEVVTF ERGHKIIISS NRRIQKGEEL CYDYKFDFED DQHKIPCHCG
AVNCRKWMN
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