ID   A0A3S4B124_9PEZI        Unreviewed;       852 AA.
AC   A0A3S4B124;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=TT172_LOCUS1173 {ECO:0000313|EMBL:SPQ18754.1};
OS   Thermothielavioides terrestris.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermothielavioides.
OX   NCBI_TaxID=2587410 {ECO:0000313|EMBL:SPQ18754.1, ECO:0000313|Proteomes:UP000289323};
RN   [1] {ECO:0000313|EMBL:SPQ18754.1, ECO:0000313|Proteomes:UP000289323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Huttner S., Dainat J.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; OUUZ01000001; SPQ18754.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S4B124; -.
DR   Proteomes; UP000289323; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd17917; DEXHc_RHA-like; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          71..133
FT                   /note="T-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50192"
FT   DOMAIN          169..370
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          406..593
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   852 AA;  94920 MW;  2EC0BD7B98E0328A CRC64;
     MSGTHQKMLD QKMEYSRRRE TEQNEQVRQE VIRSRMTAEA SRRANSQRVL GSNKPTVKKE
     FLFEDFDGTQ QEQEQEIENN LLEVSAVLAD VHDEVSALGN ELDVQNRVID QLTERSEVVI
     DDIRRGQTKL DLLSRSGIRR IQPATFGLEL RFFAARQALP LWTRRDEIRG ILRQKDVLVL
     VGETGSGKST QVPQYLFQEP WCRSRKVKVK AGAGTEEVRV GGMIAITQPR RVAATTLAHR
     VSREAGTPLS EHNSGGGGAN GAVSKGLVGY SVRFDHRVPP GTKIKYLTEG MLLQELLRDP
     HLKQYSAIIV DEVHERSVDV DLLLGFLKQI VSGDKAGRGG VPLKVVIMSA TADVEGIRRF
     FSESVSHSPG SQPSLMPKSG TSVDFLQIEG RQFPVDIVHT PKPVPDIQQA LLKLVFKFHT
     EEALSDKHGR KDILAFLTGQ EEIEAAQKLI EEYASTLASN LPKLKVFPLF GQLSMEAQHE
     AFQPVKGGFT RKVVLATNIA ETSVTVPGVR YVIDCGKAKV KQFRPRLGME SLLAKPISKS
     SAIQRAGRAG REGPGKCFRL YTEETYETLQ ETDLPEILRT DILSAVLTMK ARGIDDVLSF
     PLMDPPEVES VEKALLHLHI LGALSDDGSI TETGRKMVLF PVTPPYARVL LAAAEAKYDC
     LLEAIDIISC ITAGEDIFLQ LRSEEAKEEA EEYRKELSRR EGDLLTYLTT MQLYAAENTD
     RAQWCKDRKI HVRNMKQALN IRKQLRGLCV REGMMEPPPP DPQPFTPTSP EQAAVILKCF
     LKGFALKTAI LAPDSSYVTS HGKHVVAIHP SSVLHGQKKE AIMFLEHVYT QKNYAKKVSA
     IQASWIADAL EE
//