ID A0A401NW50_SCYTO Unreviewed; 580 AA.
AC A0A401NW50;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN ORFNames=scyTo_0007645 {ECO:0000313|EMBL:GCB65108.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB65108.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB65108.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB65108.1}.
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DR EMBL; BFAA01002814; GCB65108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NW50; -.
DR STRING; 75743.A0A401NW50; -.
DR OMA; NAEMTEY; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20435; Tudor_TDRD12_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR22655:SF2; ATP-DEPENDENT RNA HELICASE TDRD12-RELATED; 1.
DR PANTHER; PTHR22655; UNCHARACTERIZED; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..580
FT /note="RNA helicase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019400230"
FT DOMAIN 300..327
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 300..327
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB65108.1"
SQ SEQUENCE 580 AA; 66081 MW; 3BEE73444EBAD6F6 CRC64;
TTPHSLIRIL QIHCLFFIRL SHLVLDRVDV LFDEAMDEMT TILQCFREAT NVPERRSTLQ
QLIAVGKHWT KQMDSLVKEN QSDPYVVITA MEEAALYGNV HQVVQVCLDC EKTSFLLTML
DFTSEILQKT IIFTNCAEEV DHVFKVVYPI LENLVVTSLL QALGSNSNFC MKVHEGMSIH
VTNVMEQWNK KFNPGTHVIL VTTDNYLKAL RITDATCVIH YHFPPSWDIF GARLCCMVDN
FDNLIVEGSI LQSQSIILLT DKDAPQASSI LHYLERTDAK IPKELYTFIS DLNNTDAICY
DKSLCKYLKA YGICRENKAC PSRHRLHRDV DTPRCLSGVK KLPASGYVEI TPTCISDATS
YYGRIIHCRS KWEDPPVSME EDYLMLLKDM ADYYSEENHR KPVEQLVVSV LYGLEEKTYS
RVQLIGLPQK AESAVLSNAR VKYIDSGQTG QVMQKQLLEL PAKFQVLPPQ VVEFIICRVK
PIDNEMDWNP QVSRFIKQKI SNKSLNAKIV LALGNTLWLN TVVHMAKLTD LKTTILEFNI
RSEIMNSGFG TDNAEHIEQL KELCRTAGLC LTDEDSPLKQ
//
