ID   A0A498SLZ4_ACAVI        Unreviewed;      1095 AA.
AC   A0A498SLZ4;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=NAV_LOCUS5724 {ECO:0000313|EMBL:VBB30933.1};
OS   Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX   NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB30933.1, ECO:0000313|Proteomes:UP000276991};
RN   [1] {ECO:0000313|EMBL:VBB30933.1, ECO:0000313|Proteomes:UP000276991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
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DR   EMBL; UPTC01001044; VBB30933.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498SLZ4; -.
DR   STRING; 6277.A0A498SLZ4; -.
DR   Proteomes; UP000276991; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276991}.
FT   DOMAIN          288..454
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          476..698
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          187..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1095 AA;  124597 MW;  807EC653399B762D CRC64;
     MKRKVTQCAA ENVCVSLVQT EMTSDDYNNP VDTTNALILP VKTKKKKAKK ADDKVINRKK
     NEARKRRLEQ TEAKISKAKR KKLMKIMERK KKKESRESLL ENLMQYQLPT GTLSKLTAEV
     HPRKPVKSED FVPKKLSNLA GRKCISLPVK KEPVQENYYE TGSESEDDIS LTEKVISMNT
     ESSKCVLGDN DVREKQLEDS TDRRQKNSTS QNTNESKIKI KCNEVHLLEP GTSELDVANL
     PVKISSVRNK ISILKDTQKS KFVPVHRSEN IEAQRSKLPI YAEEQNIMEA INDNCATIIY
     GETGSGKTTQ LPQFLYEAGY AHDGKLIGIT EPRRMAAISM AARVAQEMNL PNAVSYQIKY
     EGNRSVETSI LFMTDGVLMK EMQKDVMLSA YSVIVIDEAH ERSMYSDVLI GLLTRIAPYR
     VRIGSPLKLI IMSATLRLDD FRNKRLFPVS LPPVLNIDAR QYPVSVHFER RTPENYLTAA
     FHKICEIHEK KGPGTILVFL SGKLERNKLE LKKTVSNKSK KTEKSVKDEL TEDRFADADN
     LDCDDSGSEI HEVNFCPEAS RTQNSSTLPL FCLPLYSLLS SKKQQRIFEP TPDGHRMCVI
     ATNVAETSLT IPAVRYVVDS GREKRRHYDP VTGVSQFLVS WISQASADQR AGRAGRVQPG
     EVYRLYSSAV YSDFEKFSPP EILSKPVDQL MLHLKSMNII KVANFPFPTP PDEDSLEEAE
     KRLIRLGALQ VTMKNNIKEA RISLLGKTLS IFPLAPTFAK ILVMANQHSL MAHACCLVAA
     LSVREPLIPL YSLRGENVEE TQALIFEALK QRRSWCPPGQ ARNFGDLTVI LRAILSAEAS
     EGSGSEEECH RLGVRRKALI EIRKLRQQLT KIINLKCPQD KPFTVKLDMK PPTDEETLML
     RQIVIASLTD NIARRVDPIA NQSVPKGAYQ SQKLKDYVYI DPSSVLFKDE PDWVLYQEII
     ERKDKKFMQN VICVEEHWLP RLANTYCHFT PIKEAEPRYD SATDTVLTFV NGTFSDRRWP
     LGKVEQPLPV NINLYRYFAQ FFLDGSVCPP LATYVTSRVR LLEVWKNKSE YLLDEYLEWL
     PKFLHEKVQM NWPPN
//