ID B6HHR3_PENRW Unreviewed; 1430 AA.
AC B6HHR3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN ORFNames=Pc21g18410 {ECO:0000313|EMBL:CAP96738.1}, PCH_Pc21g18410
GN {ECO:0000313|EMBL:CAP96738.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP96738.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP96738.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
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DR EMBL; AM920436; CAP96738.1; -; Genomic_DNA.
DR RefSeq; XP_002568835.1; XM_002568789.1.
DR STRING; 500485.B6HHR3; -.
DR GeneID; 8317168; -.
DR KEGG; pcs:Pc21g18410; -.
DR VEuPathDB; FungiDB:PCH_Pc21g18410; -.
DR eggNOG; KOG0988; Eukaryota.
DR HOGENOM; CLU_002322_0_0_1; -.
DR OMA; VHFGFSN; -.
DR OrthoDB; 2735303at2759; -.
DR BioCyc; PCHR:PC21G18410-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR Gene3D; 1.10.8.790; RNA-dependent RNA polymerase, slab domain, helical subdomain-like; 1.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF14; RNA-DEPENDENT RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT REGION 92..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 160571 MW; 115877953E31CB57 CRC64;
MDHFTTPQHQ KEDFRTFITR VNVKFGLEIP LPGIESPSVR ERNTSLPSQI YKHIRPLFFN
NKVDKRSLID NLEEWVRGNL PLAVQNNVYQ TNAGRRASQR HQSEEPAPPL SLSGPEKDMC
MRQLLALMED EEYLLANGRV VNTKKRLAAN SFGDAKGLSP KKQRFDDEDE DENFHTAPNS
PVKGSVLAQS PLGENGDGAL QFPEMAQAAF RGPRRNSGAA NLPVNNHRAI QSPARASMGI
ASPAKCQVHP SPGRNNVSVQ SPVNNKENFH SPAKYSATFP PPTKGQPAQG QGYHQSLPRK
VVPKPPSKPQ DNIPPPTRKS TSTSSPAKTP RGAQSLAKDP GSVRSPSKTL KSVDSPSQSP
LKQMDLRSFG FVNSPGKEPS AAPEDIEFKK PTLFEKLSAA SDESKRNNTT QSVNTSFSTT
VTSSIFMSRD SSMGQSFDSV MTDMTEPMDT QSTYADSVVG YMASDKMQRS VDAAAISMTV
NADPFETEYS LKHEFVDELL SYGPFSVGES FLAKIPLRFR YELERIGRAW GIPFKQILVG
DSVNFSTQDD FWSWVSKLSQ RYGCPLPERS SRRAWDAAVG DFKSDKHSEV VVLSGDLDWC
DESEPGIFKL RLNPLKPERT SRFHRRFGSD RFLTLTIPAA DRPPSHQKQL SYPSVLRESI
ASWLTRNDHH CLGRTWRAFY VEEVKTKRKA KGEPRFRVEL FAIDGDDFYH GHQLPPVVAP
PREQSDSYTP MSVDALLEWH MPKTANANQT NCKLFQRISL GLSKTFATVK LKPTQVLRLR
DDPTRPVMND GCALMSRTLA NQICDQLGIT TATPSCFQGR IAGAKGLWMI QISDSQLKIH
PHPQEWVGPV DEEKLTFEVV NWAKQLHPVD LNIQLLAILE YGGNVKEYIA KLTRDGVQSL
YDDFLEVLRS NSPVVCRALL QKLRPSGEDG TGKARRLEQW VTNDAESIIH FSEAGFAPRD
FFPLRMKIRQ YLTWLLERNV EELKIQVPLS TYAYCIADPY GVLGPDEVHF GFSNNWRDPQ
GQFEDNLLDG VDVLVGRLPA HLPSDIQRRR AVWKSELRHF KNVIVFPTTG EFPLAGMLSG
GDYDGDTPWI CWDPMIVERF QNSPMPTDEY SAEHYGLTKH SVPMASLEST EDFLESVFDF
NLNVSNLGRC TVEHEKLAYD ESVDSPKAKE LACLLGHLVD GRKGGVHLSE QAWKEYRKTI
SPKQRALPAY RNPERKSKSS NIVDYLKFNV AQSELCRILS GLNEAFPEND IQNRLDDDLL
RPWKEADEAS KSKYAHSQEL KDALGEVRRS IDELYKQWNQ GHSASTGDEF SAISRQAAEN
AGALAPPQAG RHPLIHTWQN SRNEWRRLVA SYAYRRCPNS RFILHAFGET LCEIKASVSP
SRLITNEVVA CYRVNQKMVS HLAANELPGD ESDAADEYED GEAIEAMLSF
//
