ID C1E1Z9_MICCC Unreviewed; 725 AA.
AC C1E1Z9;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=MICPUN_97165 {ECO:0000313|EMBL:ACO61832.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO61832.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO61832.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; CP001324; ACO61832.1; -; Genomic_DNA.
DR RefSeq; XP_002500574.1; XM_002500528.1.
DR AlphaFoldDB; C1E1Z9; -.
DR STRING; 296587.C1E1Z9; -.
DR GeneID; 8241765; -.
DR KEGG; mis:MICPUN_97165; -.
DR eggNOG; KOG0922; Eukaryota.
DR InParanoid; C1E1Z9; -.
DR OMA; FHEVMET; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000002009; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT DOMAIN 61..226
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 268..456
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 78509 MW; 9978E8DE782810BF CRC64;
MAFWKPGSKK PEASLPLSAE VDREGPGDSG GRLVVFNRNE NLALQAQRER LPIFKTRDAI
LHLVETRATT VLVGQTGCGK TTQVPQYLVE AGWTAGGRLV ACTQPRRVAA MTVASRVADE
MGVTLGAEVG YAVRFENVST PGVTRVRFCT DGVLLRELME DPLLSRYSVV MVDEAHERSL
ATDLLLGLLK KVQRRRPDLR IIIASATIQA EEFAAFFDTR HLEPKPASEA SSVNAPSREP
GIVSVEGRAH TVLIHYLEKP VPDYVKAAVG AAIDVHRAEG PGDVLVFLTG EEEIEAAVSM
LQEEAEDNSR RLLGGGAGTN PAGGPERFTV HPLYAGLSPA QQMEAFRPAP RYTRKIVVAS
NVAETSVTIE GVVYVVDCCF VKQKAYDPTR GMESLLTAEA SRASANQRAG RAGRVRPGKA
YRLCTEKAFR DLPETAPPEM IRSDLAATVL QLKALGIDNI MNFEWLSPPP AANMIKALEL
LYALQAIDDD ARLTKPLGMH LAELPLEPQL GKALLVSGEL GCVEEMLTVS AYLQVQTLWV
SPRGRQKRLD ECRDRFAVAE GDAVTALNIH TAWCGGRARS FADKNMLSHR ALVRASDIRA
QLARHVRRVG LVVSSAGKDS APVRRAMTAG FFANAAALAP HGGGAEGSAF RSVRGGATLF
IHPGSVLFRA RPAMVVYAAA VRTGREYMRD VTAIDPEWLS ELAPHFYAMT QRSGNERPAD
AAAVF
//
