ID C6HT40_AJECH Unreviewed; 1130 AA.
AC C6HT40;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=HCDG_09371 {ECO:0000313|EMBL:EER36487.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER36487.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG692440; EER36487.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HT40; -.
DR STRING; 544712.C6HT40; -.
DR VEuPathDB; FungiDB:HCDG_09371; -.
DR eggNOG; KOG0923; Eukaryota.
DR HOGENOM; CLU_001832_7_0_1; -.
DR OMA; HITLMNV; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EER36487.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 492..656
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 678..854
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 105..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 127857 MW; 85940CBA560F7E48 CRC64;
MDIRTYISDS LLRLTGASDA TVIDYILATT SSAKSAGSLH EKLGPFLDGD EGDIHSFCAE
LWKRVRGGSS AEDGGKKTSK EKGGDGLKKR YKLVDMEEED VDVNAGLAPL QSTEAGKLRR
KVKENGESGE SRDRDDDSRR KRAHRDARGE RKRGREGDHD RDGRHRSKKV RRRDDRDFED
QWGDEDIPED EAEMHDERLQ DEGYQHEERE PRQHSRSPRS SSPSSDIDPE TKAERARQRD
LKERDEFAKR LAKKDESKSK KIVEDRSSTK DSQAARRRAL ADDAAARSAA MPDLRLRSRQ
EYLKKREAER LALLRKQVAE ETAELRENPN LTRREKEEFA KNREVLRLAE ERLRIDDYRD
GYALPEDYIT EKGKIDRKRK EEALYKRYVD RDEHGHERFI TEHEEWENEQ TAKAKAQIQR
AEFVDEGDYE YVFDDAQKIN FIMDSKLEGD RKPLTKDQLL FQQKLDAAEQ KAASIEETRK
SLPIYRFREE IIRAVADHQV IIIVGETGSG KTTQIPQYLH EAGYTKGGMK IGCTQPRRVA
AMSVAARVAE EMGVKVGNEV GYAIRFEDAT SDKTVLKYMT DGMLLRELLT EPDLGGYSAL
MIDEAHERTV STDIACGLLK DIAKARPDLK LLISSATIDA QKFQKYFDDA PIFNIPGRRY
PVDIHYTSQP EANYLAAAIT TVFHIHISQG AGDVLVFLTG QEEIEAAEQS IQETARKLGS
KIPELIICPI YANLPSELQA KIFEPTPPGA RKVVLATNIA ETSLTIDGIV YVIDPGFVKE
NVFNPRTGME SLVVTPCSRA SAGQRAGRAG RVGPGKCFRL YTKWAFYNEL EENTTPEIQR
TNLNGVVLML KSLGIDQLLD FDFMDPPPAE TLIRALEQLY ALGALNDHGD LTKVGRQMAE
FPTDPMLARA ILAADKYGCV EEVLSIIAML GEASALFFRP KDKKIHADSA RARFTIKDGG
DHFSLLNVWN QWVDSDFSYV WARENFLQQR SLTRARDVRD QLAKLCDRVE VTITSAGSNN
LAPIQKAITA GFFPNAARLQ RGGDSYRTVK NGQTVYLHPS STLFEVNPKW VIYYELVLTS
KEYMRSNMPL QPEWLVEVAP HYHKKKDLET LGIDRKVPKG QGATGEKSKI
//
