ID D0NUZ8_PHYIT Unreviewed; 1156 AA.
AC D0NUZ8;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=PITG_17084 {ECO:0000313|EMBL:EEY66470.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY66470.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; DS028167; EEY66470.1; -; Genomic_DNA.
DR RefSeq; XP_002896989.1; XM_002896943.1.
DR AlphaFoldDB; D0NUZ8; -.
DR STRING; 403677.D0NUZ8; -.
DR EnsemblProtists; PITG_17084T0; PITG_17084T0; PITG_17084.
DR GeneID; 9466573; -.
DR KEGG; pif:PITG_17084; -.
DR VEuPathDB; FungiDB:PITG_17084; -.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_001832_1_4_1; -.
DR InParanoid; D0NUZ8; -.
DR OMA; HMECGSA; -.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EEY66470.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 64..129
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 236..405
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 554..736
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 128051 MW; B7B783BE493BF9A8 CRC64;
MERNGEWQAR GGRGNRGRGG RRGRGRGRGR GGQSGRSPPS NGFTSSNGRN ASNSSSEPAI
SLDESFTMEI HAALQALVED GERTEMSFSP SYDNTQRRYI HSMAQKYGLF SKSSGKKGAG
RFIHVAKVKK NAAMQEVSLR LPAAPLNAAT VEWFPPVIKT YMERYPAPTE EVTVDPWSAK
DLSPLASVPK RHPGRGGGSP FKPLPSPPKD VGTKVVRTPL VEATKLPVYG YREQILELVE
SNQLVVLSGD TGCGKSTQIP QFLLDDALAR GRGEETRIIC TQPRRISAIS LAERVARERT
GQDPKEVGHA IRFDSSFDAK RSKLIFCTTG TLLKWLNNDP LARGFSHIIL DEVHERDQFT
DFLLILIKTS ILKQRPDLKV ILMSATIQVE KFSQYFQPEF PAPVLQMVGG TNFPVTTLYL
EDILALLERD RSSPLPIMDD SRVGRIGGGS FGHVATAPAS NGLECPLCGE TRIADEEAFG
MHVATCFGEP SADFEAVAVP EPELATVAVP VAAMGDVLQA ALSEINDDAK EALLSSYVKQ
QDALRQDQAV DYDVLLQLLF LVNRTFPLDE DGKGAILVFL PGWEEISFME RALLNSPATS
STYEIALLHS RLSAQEQRRA FMTPPHGKRK LVLATNIAET SLTIEDVVFV VDCGKSKQAH
ALAATSSSSF VMGLQTTWVA RANCVQRTGR AGRVRAGICF RLFSKARYET AMKEFMQPEL
LTTPLEELLL QIKLLQLEKK LHIRDAKEFL LEAMDAPSET SIDASLQRLE DMRALVGISK
GKQALTLLGW HLGHICSGGV SVQMAKLLLW GHTFGCFDAI LQTTCTLSGY RDPFISFLGM
SPEEQRQVDA SKKAFARNGS PPGLTLQSDH FVLWKAFEAY LDARARSSFK AKDAFCARNK
LHRQTLEQLY SIYRQLQQDL DQLGLSTATQ LVPTPVSRMP ATVESVTPYL MALSIGMYPN
ALFTRSGGVS RNWTSKEKVK VKMDGTSMVA WTASNTQKHK RKIGSEQDEF GPPDEWLVYH
EMMQSERTRL AKYGTKLPSQ LLQALLVGSV ETQTVEQQDV DMDDTDDAVA AKWLLVLDDW
IVYELCGHDE ARWLALLRER LHASFIRHLE RLHDNAQHGC ARPLSGTDQQ LQQHDAELLQ
ALSAWISSDL HRGARR
//
