ID D4ADC2_RAT Unreviewed; 2967 AA.
AC D4ADC2;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=Helz2 {ECO:0000313|Ensembl:ENSRNOP00000017787.5,
GN ECO:0000313|RGD:1306056}; Synonyms=Pric285 {ECO:0000313|RGD:1306056};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000017787.5, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000017787.5, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017787.5,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000017787.5}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017787.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; D4ADC2; -.
DR STRING; 10116.ENSRNOP00000017787; -.
DR PaxDb; 10116-ENSRNOP00000017787; -.
DR PeptideAtlas; D4ADC2; -.
DR Ensembl; ENSRNOT00000017787.6; ENSRNOP00000017787.5; ENSRNOG00000013267.8.
DR UCSC; RGD:1306056; rat.
DR AGR; RGD:1306056; -.
DR RGD; 1306056; Helz2.
DR eggNOG; KOG1804; Eukaryota.
DR eggNOG; KOG2102; Eukaryota.
DR GeneTree; ENSGT00940000160694; -.
DR HOGENOM; CLU_000407_0_0_1; -.
DR InParanoid; D4ADC2; -.
DR OMA; ATLQYCC; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000013267; Expressed in liver and 17 other cell types or tissues.
DR Genevisible; D4ADC2; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008859; F:exoribonuclease II activity; ISO:RGD.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR CDD; cd18040; DEXXc_HELZ2-C; 1.
DR CDD; cd18808; SF1_C_Upf1; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 3.
DR Pfam; PF13087; AAA_12; 2.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D4ADC2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 781..972
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1565..1923
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT DOMAIN 2460..2702
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 2967 AA; 334109 MW; 00858D5E1F30494F CRC64;
MASVGCGLRS TSTSTTNGLS LAELCAKVDL HLGCSRCTEY LNESTYILRE VEHTCSREIL
LARFKQAAKN KVWRKVGLRP SFPIPVRYQV CRYYSPGLGC KRHWNRCTFA SSPEEALVWT
FELKNNLTRL KLKEAVQGTR APDRLQTPAD TIRAEFGGHF QLLCALCFKC RPPCLCPVDS
RGHCPKHQIC PTLLIHVIVE GQKRQFVEVR PLPQKRHPLN YCMFVGRGVP CRHGASRCGY
AHSAVEMAVW KAEQLDGLQR GDLLTYPLFG EDKQKASHGQ PPAVKLYCHA CLVTCSSQEA
FENHCSSLEH AQMVAFDQVV PRKHRAPPMG LSKFELCPRP DLCEYGEVCI KAHSKQELQE
WVQRAQDMEL REQAAWQDGL VPYQARLLAE YRRSSKEVLV MAETVHGVSV TCQQPLVHQA
QEKIQHKWVF TIHSEDPLLH VALLKQEPGA AFSLVAPHLP PHQLYAQGKH FCVPNSPAQF
QVGVLVQAAS FGSFEQWVVF DFGRRPVLLQ KLKLQLGQTH SLGLNGKPAP SHPQERECWH
TGNRHVVLEV DWTPEQEALM AKYKLPSLAL EFSHNVVVWG PISRTNYRQR MHKFLYEEEA
AQQQLVAKLA MKGQVSLKTA LETPALGMLF APPGALYAEV PFPSSLLPDT DQGFLMSRAV
STALVAPAPA PDSKVYQVRL EARASSEHAL WLLLPARCCM ALGLQAQDSP VLEVQFQIDP
LIFRFWHRAV DALPEVCLVV PDLPACTLPH PWPTPPSFRG NHKQKLAVGL IAGRRPEGSK
HIPPLLIYGP FGTGKTYTLA MAALEVVQQP HTKVLICTHT NSAADIYVRE YFHGYVNSGH
QEAAPLRVMY ADRPPRQTDS TTLQYCCLTE DRQAFRPPTF PELLRHRLVV TTTSQARELQ
VPAGFFSHIF IDEAAQMLEC EALIPLSYAL TLTRVVLAGD HMQVTPRLFS VPRDKAAGHM
LLHRLFLYYQ QEVHKIAQHS RIVFHENYRS TAAIINFVSR HFYVAKGNPI QASGKVPRHP
QHYPLMFCHV AGSPEQDMSR TSWLNSAEVT QVVEKVQEIY NTWPHCWGPR EQRHICAVSH
GAQVSALRQE LRRRNLGEVS VGSFEILPGR EFRVVVLSSV HNRNSLLSPG APTSEFFTEP
RVLNTVMTRA QSQLVAVGDA VALCSSGACR KLWKNFIREC IEHHSIFPED LSLEQIEQGV
AQRQNWASLM LRAWDTEAEH KPTAQDLQRP IAEGTMVTVK AETRARAAAT AQTEAVAAGG
TARRNSASTD AAAEVSTLEG YEEDSESDLW PSDWELNADD AILKELLDES RQMTVTVRED
GLLDTMVCPA SSQKARQYIN LPSSALRKYL RLDPKQYRRC SFLQETFERA LATPLDDMAS
SPIQVRGRLN CGMAFTGDEV LVQILGPAVD DKSIPGSLLG RVMGVLKRRR RELAFVCRMD
EWDPHIMIPI NSSVTKIFVA GLKDPQQVPI HCLIEGKVKH VRHETLKRED RSTRLFWVRI
VLWRERFYYP LGIVLEVLPK AVTWEQGLHI LDLEHGLKAH TPDPASVSKA LQKYHSEIDM
AASHREDYRR FLTFTVDPQG ACNLDDALSV RDLGPVYEVA VHIADVASLV PKDGALDVEA
RQQGTVFYAP SREPVLMLPA SLCQEALSLL PGQDRLAISL FLTMEKGGGG QIRSLRFAPS
IVRSDRQLSY EEAEELIKRH PGAGLKLPAH LDSVEACVVA ACYFSWMLRR QRLPADCYYE
PPDEDSVLGF RTAHIMVQEY MIQFNSRVAE FLVGDKHTQT LTPLRWQPTP SRQQLDSVFK
KHRGLVPLSL HLCHHSNTHY TPNKRLYLLT SLWKQVQLAA GTRDYSQMVD LIATEDMHPS
LAPACLDFRR ALGRSVFGRS SQGRQRPAGH YSLQVDWYTW ASSPIRRYLD VVLQRLILLA
LGHKSSTYSN RDIDGLCQDF SRQYACAQSY QRRACSLHLA IQLKTQPQNK LGFVVDVETG
ARCFKVLFPI NRETLPDPCP IHYHSLQLAE NPEELVGQTG LRLVWRRRTY SVQASKLPLP
HLGTSFDPLT QTIDAALWMK LLVLLKEERW PEVAALIQEQ DKLSRQREKA QVHQSRCGHF
IEVAYELGSG DTLQVQLGSS LQRGFLAPTL QLWTVVPGFS LCLEHMERPG DCFSGHVHQP
LQDQYLEVSQ YSGVWGPRCA LESLMSAVAE NDSIVLQDVH IYWDTSQEQL QGTFQLEAAF
LQEKCINIHF GCCYLCIRLE GLPLPLASSL PGPSDLGPFL NIDPNTYTWV AHGLSGDWDH
ELAGDWDQEC VDDRQEVPKQ VHFFIHHMTM EKVPEEVLRP STRFTVEVLS KQLPDLRKEE
AVRGLKNASP LVISIALGLP ILEPHWPIPE PRHQISWPRH QISWPRHPIS GPCLPVSGLC
LPVSGLCHPI PEPCRRGWPP QHSSRKVPTS RFLERKNYNI PGGHHKLNQS QDKAVRSALQ
KQFTVIQGPP GTGKTVVGFH IVYWFHRSNQ EQMPTGSSPS EEEKLGGPCV LYCGPSNKSV
DVLGGLLLRK KTEMRPLRVY GEQAEATEFP LPGVSNRSLF GKISQEGRPN QSLRSITLHH
RIRQAPNPYA AEIRKFDAQL REGKIFSKDD LLVYRRVLGK ARKYELERHS VILCTCSCAA
SGSLKALNVR QILIDEAGMA TEPETLIPLV CFSKTEKVVL LGDHKQLRPV VKNEQLRNLG
MDRSLFERYH RDAIMLDTQY RMHKDICSFP SMEFYGGKLK TWSDLKRPPS LLGHVGKQSC
PVIFGSVQGY EQKLLVSTEE GNENSRANPE EVTEVVRIIK QLTLDRTVDP KDVAVLTPYN
AQAAAISRGL MQRGVTGVTV TSITKSQGSE WRYVIVSTVR TCPRSDMDQR PTKSWLKKFL
GFVVDPHQVN VAITRAQEGL CIIGDHLLLR CCPLWHRLLG FCEAQNSLVP AERCDNPPPQ
SPEVRDAASE IYTRTAGVPK AWLRSLL
//
