ID   D5GCP2_TUBMM            Unreviewed;      1218 AA.
AC   D5GCP2;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=GSTUM_00000785001 {ECO:0000313|EMBL:CAZ82285.1};
OS   Tuber melanosporum (strain Mel28) (Perigord black truffle).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Tuberaceae; Tuber.
OX   NCBI_TaxID=656061 {ECO:0000313|EMBL:CAZ82285.1, ECO:0000313|Proteomes:UP000006911};
RN   [1] {ECO:0000313|EMBL:CAZ82285.1, ECO:0000313|Proteomes:UP000006911}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mel28 {ECO:0000313|EMBL:CAZ82285.1,
RC   ECO:0000313|Proteomes:UP000006911};
RX   PubMed=20348908; DOI=10.1038/nature08867;
RA   Martin F., Kohler A., Murat C., Balestrini R., Coutinho P.M., Jaillon O.,
RA   Montanini B., Morin E., Noel B., Percudani R., Porcel B., Rubini A.,
RA   Amicucci A., Amselem J., Anthouard V., Arcioni S., Artiguenave F.,
RA   Aury J.M., Ballario P., Bolchi A., Brenna A., Brun A., Buee M.,
RA   Cantarel B., Chevalier G., Couloux A., Da Silva C., Denoeud F.,
RA   Duplessis S., Ghignone S., Hilselberger B., Iotti M., Marcais B., Mello A.,
RA   Miranda M., Pacioni G., Quesneville H., Riccioni C., Ruotolo R.,
RA   Splivallo R., Stocchi V., Tisserant E., Viscomi A.R., Zambonelli A.,
RA   Zampieri E., Henrissat B., Lebrun M.H., Paolocci F., Bonfante P.,
RA   Ottonello S., Wincker P.;
RT   "Perigord black truffle genome uncovers evolutionary origins and mechanisms
RT   of symbiosis.";
RL   Nature 464:1033-1038(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; FN430119; CAZ82285.1; -; Genomic_DNA.
DR   RefSeq; XP_002838094.1; XM_002838048.1.
DR   AlphaFoldDB; D5GCP2; -.
DR   STRING; 656061.D5GCP2; -.
DR   EnsemblFungi; CAZ82285; CAZ82285; GSTUM_00000785001.
DR   GeneID; 9187903; -.
DR   KEGG; tml:GSTUM_00000785001; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   HOGENOM; CLU_001366_2_0_1; -.
DR   InParanoid; D5GCP2; -.
DR   OMA; PNAVTLY; -.
DR   OrthoDB; 5477883at2759; -.
DR   Proteomes; UP000006911; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF17; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006911};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   1218 AA;  137813 MW;  1450F33982576FDC CRC64;
     MEIFIQNIPY SSGRDSQLRR TLEPHLNEIG VLAFRATVFK RKPGKGSWKN GALTVPTQEA
     GKKFLSLYGA RNSGVAQRMI RMQGTPLRFV ISNKGCDHYV VKSLQKEQES LIKESLQQPQ
     IQRTRPPGKK FDIEKVECGV WSTETEGCAP VFDCYYSINV VGTLRFGGRA VHAVFESECD
     PSQDDPLSLV FERLGLEVQS DGSSTNKSIV ARYIDMISIV VSNWDSKSVT FTLDKAPRFY
     EETTQQDELL FGFFGKDVRR RVSCLGADHA LYAPFAFVYR IHLKEAHEID SIMLLGEHRG
     IPPVIEKRTD TRSAVFEFQE SSKELVAKLQ RQFFGPEMFP IAFQLNAMWA GGYLPPSSVL
     RLLPQVGSFI RRHGCEQTAT ILQEFVESSG REDPMNEPGT FSHQALTSGL DGCAAFASSR
     KGSLIASKLE RAQKKHMALV HHVSITPAGC YFFGPLPEPQ NRVLRKYPDH HEYFIRVTFC
     EEDGEPLLFQ HKVDQSPIYK NQFRFYLSEG ITIAGRKFEF LGFSSSSLRT QSCWFMAPFY
     LDGKYLDPKI VTSRLGDFSS ITCPGKYAAR VGQAFSDTYG SIDVRAEHEV EIPDVVRNGR
     TFSDGVGTIS QQLLDRVWRE SESLRKTRPT VFQIRFAGAK GVVSLDTRLV GDKFCLRPSM
     IKFRGSSDRK IEICNSADWL PMYLNRPLIK VLEDIGVFES TFMTLQKEAI EDLRQSTTSV
     ANAANFLKRQ RIASTAIRLP WVIESLNNLG FNFRDDHFLE QAFELSLITS LRSLKHKARI
     PVKKGMTLVG VMDETGYLQE GQIYVTVQAR DKSTSESIAG RVLITRSPVH HPGDVQMALA
     IGTNQLPPDS PLRALRNCVA FPQRGERDMP SMLGAPDLYN IIYDARFSLK TTYDPAEYPK
     VPTKDLGRPV KTSDIVDFFL EFMENNLLGM ISSRHLITAD KKVEGVHHPD CLKLAELAST
     AVDFPKTGIK VSRSDFPKAT FAKPDFMAPG PRILIKRGPE FVEEDVVPDD DDDDEDTPTL
     YYESEKVLGK LYREIDETAF LREVQGTVNK ERRARNVDEG AVVLGIWEWL EEAIPSNYKW
     EDYIGVAAEL KEAYEGNVER MMLNYSDMPW KYRLREVEVF IGNIVGKERQ TQRQKDASSQ
     MRDEFDRLAS SIVESMQSES REKTLGIGMA SLSLCLPEKN WKDLDSLKSF TWIAVSVLLT
     EVDKMQKEAK SKGGRRLR
//