ID   E6V1Y7_VARPE            Unreviewed;       536 AA.
AC   E6V1Y7;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:ADU37990.1};
DE            EC=1.1.99.1 {ECO:0000313|EMBL:ADU37990.1};
GN   OrderedLocusNames=Varpa_3809 {ECO:0000313|EMBL:ADU37990.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU37990.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU37990.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU37990.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT   paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-e00813(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; CP002417; ADU37990.1; -; Genomic_DNA.
DR   RefSeq; WP_013542213.1; NC_014931.1.
DR   AlphaFoldDB; E6V1Y7; -.
DR   STRING; 595537.Varpa_3809; -.
DR   KEGG; vpe:Varpa_3809; -.
DR   eggNOG; COG2303; Bacteria.
DR   HOGENOM; CLU_002865_7_1_4; -.
DR   OrthoDB; 9785276at2; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003968};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003968};
KW   Oxidoreductase {ECO:0000313|EMBL:ADU37990.1}.
FT   DOMAIN          83..106
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00623"
SQ   SEQUENCE   536 AA;  57915 MW;  265F7B422AC1BA55 CRC64;
     MNTSQDYDYI VVGGGSAGCL LANRLSADPS QRVLLIEAGA RDNSIFIRMP AGFSRVFGTH
     RMWDYQSEPQ AGLGGRTAFV PQGRTLGGSG SMNGMIYIRG DRQDYDDWRD GGCSGWGYED
     VLPWFRKSEG NQRLSDAYHG AAGPLKVIDT PYRHALNAAF VRSAQEIGLP FNHDFNGASQ
     LGAGFYQITS FEGERGNTAR FFLRPAMGRP NLEVRTDLTA ARVQFDGTRA TGIECLESKG
     HHAAVAFRAR REVILCAGGL GSAKILLQSG VGPGAQLQAV GVPQVKELAG VGRNYQDHLE
     VPVYGQTREP ISLFGHDRGL SALRHGAQWV LFRSGLMTSN VVESGGFFDT DGDGRADIQF
     HVLPVLVGDA DRAPPMVHGI TLNPCQLAPK SRGELRLRSS DPLDLPWLDA GALADEDDVR
     VLREGVRLAR RILAAPSLAA LVSREIEPLP EFAGDDDADI DARVRHYAKT VYHPGGTCKM
     GTDAMAVVDP QLRVHGLQGL RVADVSVMPA IPRGNTNAGT IMIAERAADF IQSERA
//