ID G1PL21_MYOLU Unreviewed; 787 AA.
AC G1PL21;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=ATP-dependent RNA helicase SUPV3L1, mitochondrial {ECO:0000256|ARBA:ARBA00021960};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=Suppressor of var1 3-like protein 1 {ECO:0000256|ARBA:ARBA00031873};
GN Name=SUPV3L1 {ECO:0000313|Ensembl:ENSMLUP00000011532.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011532.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011532.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011532.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR EMBL; AAPE02056546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02056547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006107356.1; XM_006107294.2.
DR RefSeq; XP_014304754.1; XM_014449268.1.
DR RefSeq; XP_014304755.1; XM_014449269.1.
DR AlphaFoldDB; G1PL21; -.
DR STRING; 59463.ENSMLUP00000011532; -.
DR Ensembl; ENSMLUT00000012673.2; ENSMLUP00000011532.2; ENSMLUG00000012664.2.
DR GeneID; 102426686; -.
DR KEGG; mlf:102426686; -.
DR CTD; 6832; -.
DR eggNOG; KOG0953; Eukaryota.
DR GeneTree; ENSGT00390000003100; -.
DR HOGENOM; CLU_010647_3_2_1; -.
DR InParanoid; G1PL21; -.
DR OMA; QPANWYT; -.
DR OrthoDB; 161833at2759; -.
DR TreeFam; TF106432; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016817; F:hydrolase activity, acting on acid anhydrides; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17913; DEXQc_Suv3; 1.
DR CDD; cd18805; SF2_C_suv3; 1.
DR Gene3D; 1.10.1740.140; -; 1.
DR Gene3D; 1.20.272.40; -; 1.
DR Gene3D; 1.20.58.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022192; SUV3_C.
DR InterPro; IPR041082; Suv3_C_1.
DR InterPro; IPR044774; Suv3_DEXQc.
DR InterPro; IPR041453; Suv3_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF12513; SUV3_C; 1.
DR Pfam; PF18147; Suv3_C_1; 1.
DR Pfam; PF18114; Suv3_N; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 354..522
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 37..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 87852 MW; F7C46F2682D79A04 CRC64;
MSFPRCALLW ARLPAGRRAG HRAAVCSALR AHGGPVPGPL GRTPAVASAS SSASGGSKAP
NTSLFVPLTV KPQGPSADGD VGAELTRPLD KNEVKKILDQ FYKRKEIQKL GADYGLDARL
FHQAFISFRN YILQSHSLDV DIHIILNDIC FSAAHVDDLF PFFLRHAKQI FPVLECKDDL
RKISDLRIPP NWYPEARAIQ RKIVFHSGPT NSGKTYHAIQ KYLSAKSGVY CGPLKLLAHE
IFEKSNAEGV PCDLVTGEER VSVEPNGKQA AHVACTVEMC SVTTPYEVAV IDEIQMIKDP
ARGWAWTRAL LGLCAEEVHL CGEAAAIDLV TELLYTTGEE VEVRNYTRLT PISVLDHALE
SLDNLRPGDC IVCFSKNDIY SVSRQIEIRG LESAVIYGSL PPGTKLAQAK KFNDPDDPCK
ILVATDAIGM GLNLSIRRII FYSLIKPSIN EKGEKELEPI TTSQALQIAG RAGRFSSKYK
EGEVTTMNRE DLRLLKEILN KPVDPIKAAG LHPTAEQIEM FAYHLPDTTL SNLIDIFVDF
SQVDGQYFVC NLDDFKFSAE LIQHIPLSLR VRYVFCTAPI NKKQPFVCSS LLQFARQYSR
NEPLTFAWLR RYIKWPLHPP NNIKDLMDLE AVHDVLDLYL WLSYRFIDMF PDASLVRDLQ
KELDGIIQEG VHNITKLIKI SEAQRLLNLE NVSADSRSRL PGTLKSQARR MRGTKTLGYK
AVEPPSPSAE EKSLASRLVQ QGLLTADMLK QLEKEWLTQR TEHGKDRTAP GTSSKGSRRK
KKEPDSD
//
