ID G5C682_HETGA Unreviewed; 438 AA.
AC G5C682;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
GN ORFNames=GW7_02378 {ECO:0000313|EMBL:EHB17043.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17043.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17043.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR EMBL; JH173492; EHB17043.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C682; -.
DR STRING; 10181.G5C682; -.
DR eggNOG; KOG2369; Eukaryota.
DR InParanoid; G5C682; -.
DR OMA; PWQWVPL; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EHB17043.1};
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transferase {ECO:0000313|EMBL:EHB17043.1}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..438
FT /note="Phosphatidylcholine-sterol acyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003475158"
SQ SEQUENCE 438 AA; 49597 MW; 053CE8D87570AA4D CRC64;
MGPPGSPWQW VLLLLLLPPA SPFWLLNVLF PPHTTPKAEL SNHTRPVILV PGCLGNQLEA
KLDKPDVVNW MCYRKTEDFF TIWLDLNMFL PFGVDCWIDN TRVVYNRSSG RVSNAPGVEI
RVPGFGKTYS VEYLDSNKLA GYMHTLVQNL VNNGYVRDET VRAAPYDWRL EPSQQEEYYQ
KLARLVEEMY AAYGKPVFLI GHSLGCLQLL YFLLRQPQSW KDHFIDGFIS LGAPWGGSTK
PMLVLATGNN QGIPLMSSIK LREEQRITTT SPWMFPSYQV WPEGHVFIST PSFNYTGRDF
QRFFADLHFE DGWYMWLQSR DLLAGLPAPG VEVYCLYGVG LSTPSTYIYD HGFPYSDPVN
VIYEDGDDTV ATRSSELCGL WQGRQPQSVY LLPMNGTQHL NMVFSNQTLE YINAILLGAY
RQGSPAPPTA SPGPLPPE
//
