ID G7EAM0_MIXOS Unreviewed; 608 AA.
AC G7EAM0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Proline dehydrogenase {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
DE EC=1.5.5.2 {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
GN Name=Mo06583 {ECO:0000313|EMBL:GAA99880.1};
GN ORFNames=E5Q_06583 {ECO:0000313|EMBL:GAA99880.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA99880.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC {ECO:0000256|RuleBase:RU364054}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC ChEBI:CHEBI:132124; EC=1.5.5.2;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- SIMILARITY: Belongs to the proline oxidase family.
CC {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA99880.1}.
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DR EMBL; BABT02000241; GAA99880.1; -; Genomic_DNA.
DR AlphaFoldDB; G7EAM0; -.
DR STRING; 764103.G7EAM0; -.
DR eggNOG; KOG0186; Eukaryota.
DR HOGENOM; CLU_018202_1_1_1; -.
DR InParanoid; G7EAM0; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR002872; Proline_DH_dom.
DR InterPro; IPR015659; Proline_oxidase.
DR PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR Pfam; PF01619; Pro_dh; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU364054};
KW Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU364054};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW ECO:0000256|RuleBase:RU364054};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131}.
FT DOMAIN 186..580
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
SQ SEQUENCE 608 AA; 66371 MW; A11A122CCF93B0C5 CRC64;
MLLARALALQ RVPHRVSAAQ EAFFVVPKPC RYTSTAQAGT RQQWRASGSR ATRIAAFSLL
ATGATIYYLR HQDLRIREHQ ELAVARSAAI SDPLDVLNPA EMAKGKHLRA MPLPVLLRSY
LVYALSSSGF IVEQSPKIIS ALETVRDTVP LVGPLVWSTF AGVMRNTFFA HYVGGETVPG
CFGLMDELEK EGCSAMLNYS VEKDASTAAQ SGIIDENVEE IHRAIVASGH AGRARSTWVA
IKITGLVHNP GLIQRASEAL ASSTAYQRGQ LAVSADTLFP AGPALSEQDH VDLDSLLEGL
RKACSQAKAL GVRVAIDSEQ SWYHPAIDHI HDLLAIEFNR VEAPPDLRKP GFLARWIWGD
RIPLTPSSVP PTVFNTFQCY RKDTEERLSI SLARSVQLNH SLGVKLVRGA YADTERARAL
AAGLKTSPVW DSKPETDACY DRCAAICVER VDHDLNTARG QWSPGIGILI ATHNATSVKR
MLTDLRARKL IMNAGARLDV SEEVRGRICF AQLLGMSDAL TFALSQLFSG SETVPSYNTA
TSISPYPVSP LPIVAKYIPY GPLDRALPYL IRRAQENRSV LTGADGSGRG GASDERRLIG
AEIRRRFL
//
