ID H0WY63_OTOGA Unreviewed; 1044 AA.
AC H0WY63;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX16 {ECO:0000313|Ensembl:ENSOGAP00000007432.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007432.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007432.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AAQR03060088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03060089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003789022.1; XM_003788974.2.
DR AlphaFoldDB; H0WY63; -.
DR STRING; 30611.ENSOGAP00000007432; -.
DR Ensembl; ENSOGAT00000008304.2; ENSOGAP00000007432.2; ENSOGAG00000008300.2.
DR GeneID; 100950408; -.
DR KEGG; oga:100950408; -.
DR CTD; 8449; -.
DR eggNOG; KOG0923; Eukaryota.
DR GeneTree; ENSGT00940000158480; -.
DR HOGENOM; CLU_001832_7_1_1; -.
DR InParanoid; H0WY63; -.
DR OMA; HITLMNV; -.
DR OrthoDB; 5488182at2759; -.
DR TreeFam; TF313473; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR CDD; cd17974; DEXHc_DHX16; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 412..576
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 601..774
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 100..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 119806 MW; 7AD9242238FF3C01 CRC64;
MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCASA EEFVQRLRDT DTLDLSGPAR
DFALRLWNKV PRKVVLEKPS RAAEREARAL LEKNRSYKLL EDSEESSEET VNRAGSSLQK
KRKKRKHLRK KHQEDEEEEE EDTSEKGKRK TEGSNQQTEK PESEDEWERT ERERLQDLEE
RDAFAERVRQ RDKDRTRNVL ERSDKKAYEE AQKRLKMAEE DRKAMVPELR KKSRREYLAK
REREKLEDLE AELADEEFLF GDVELSRHER RELKYKRRVR DLAREYRAAG EQEKLEATNR
YHMPKETRGQ PARAMDLVEE ESGAPGEEQR RWEEARLGAA SLKFGARDAA SQEPKYQLVL
EEEETIEFVR ATQLQGDEEP SAPASSTQAQ QKESIQAVRR SLPVFPFREE LLAAIANHQV
LIIEGETGSG KTTQIPQYLF EEGYTRKGMK IACTQPRRVA AMSVAARVAR EMGVKLGNEV
GYSIRFEDCT SERTVLRYMT DGMLLREFLS EPDLASYSVV MVDEAHERTL HTDILFGLIK
DVARFRPELK VLVASATLDT ARFSTFFDDA PVFRIPGRRF PVDIFYTKAP EADYLEACVV
SVLQIHVTQP PGDILVFLTG QEEIEAACEM LQDRCRRLGS KIRELLVLPI YANLPSDMQA
RIFQPTPPGA RKVVVATNIA ETSLTIEGII YVLDPGFCKQ KSYNPRTGME SLTVTPCSKA
SANQRAGRAG RVAAGKCFRL YTAWAYQHEL EETTVPEIQR TSLGNVVLLL KSLGIHDLMH
FDFLDPPPYE TLLLALEQLY ALGALNHLGE LTTSGRKMAE LPVDPMLSKM ILASEKYSCS
EEILTVAAML SVNNSIFYRP KDKVVHADNA RVNFFLPGGD HLVLLNVYTQ WAESGYSSQW
CYENFVQFRS MRRARDVREQ LEGLLERVEV GLSSCQGDYI RVRKAITAGY FYHTARLTRS
GYRTVKQQQT VFIHPNSSLF EQQPRWLLYH ELVLTTKEFM RQVLEIESSW LLEVAPHYYK
AKELEDPHSK KMPKKIGKTR EELG
//
