ID H2TV28_TAKRU Unreviewed; 1415 AA.
AC H2TV28;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(27) demethylase {ECO:0000256|ARBA:ARBA00034525};
DE EC=1.14.11.68 {ECO:0000256|ARBA:ARBA00034525};
GN Name=kdm6a {ECO:0000313|Ensembl:ENSTRUP00000028537.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028537.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000028537.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000028537.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-
CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224,
CC Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.68; Evidence={ECO:0000256|ARBA:ARBA00034421};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the UTX family. {ECO:0000256|ARBA:ARBA00034483}.
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DR STRING; 31033.ENSTRUP00000060482; -.
DR Ensembl; ENSTRUT00000028651.3; ENSTRUP00000028537.3; ENSTRUG00000011300.3.
DR GeneTree; ENSGT00940000166518; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032452; F:histone demethylase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1370; -; 2.
DR Gene3D; 2.10.110.20; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR046941; KDM6_GATAL_sf.
DR InterPro; IPR048562; KDM6A_B-like_C-hel.
DR InterPro; IPR048560; KDM6A_B-like_GATAL.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14017; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR14017:SF9; LYSINE-SPECIFIC DEMETHYLASE 6A; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF21322; KDM6_C-hel; 1.
DR Pfam; PF21326; KDM6_GATAL; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 99..132
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 136..169
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 324..357
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1109..1272
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 20..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..951
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 153920 MW; D21186DE7B072BBC CRC64;
MQSCGVSVAV AACAAARSLG SASSGGDEGK KMAAGKASET EEDFPTLTTQ ERDSLVGIDS
SLFGFQKLHE DGARTKALLI KAVRCYDSLI LKAEGKVEPE LFCQLGHFNL LLEDYPKALS
AYQRYYSLQS DYWKNAAFLY GLGMVYFHYN AFQWAIKAFQ EVLYIDPGFS RAKEIHLRLG
LMFKVNTDYE SSLKHFQLAL IDSNPCTLSK AEIQFHIAHL YEIQKRYRAA KEAYESLLQT
EDLPAQVKAT TLQQLGWMHH TVEQLGDRAS RESYAIQCLQ KSLEADPNSG QSWYFLGRCY
SSIGKVQDAF ISYRQSIDKS EASADTWCSI GVLYQQQNQP MDALQAYICA VQLDHSHAAA
WMDLGTLYES CNQPHDAIKC YINATRSKGC TNTTALAHRI KCLQAQLSNP QLSSLQGKSK
MLPLIEEAWS LPIPAELTSR QGGLSSAQQQ SDSWAGNTAP QPVPSWYLSP QKLQLLEQLR
SNRASLKPPQ LQMLGQLEAQ LAMMHQHQMR QNSSGVQVRP SLSNGPTVNS LPSPNPSLQP
TRPHMGPHRP VGPQPQLLAN GPVGHAESLP VGNNSSNQPG PTATGPNGDV PYLQPAGSGD
AATLPHTCTR TQTQDSAPRQ ALHLNSSQGL QKESTPPGTD STSEGTISLT QTPNTTTPTP
THPSNQVGHS TDVPSPPQQA HNHLSSPPSL PHTSTSGGAA PGATKDSNTA ATSPGNGGSE
GKAPSPLPSA ESKTAQADGL GNHLHSVDAG KVAEGGEKSS LSADNPRLSA LLAGGKGSEE
TEGPSEGATS TASAMPETHK KINNIHPAAL PSTPHAQGSS AASSPISAIS TATPSPKSTE
HTQTGAHSPA TTSTSAAPAV NGNGKGGISE DSQSPLKAEP PTVSSLKATP PHGHSSSSSS
SISIYPSSTD VLKACRNLGR NGLSNSSILL DKCPPPRPPP PPSPALPKDK LNPPTPSIYL
ENKRDAFFPP LHQFCTNPSN PVTVIRGLAG ALKLDLGLFS TKTLVEANPE HLVEVWTQLS
QPADENWDPA GTKKMWRCES ARSHTTIAKY AQYQAASFQE SLREENEKKA LKEPSDVEPA
SSESIVHKRR GPLKHIKFGT NIDVSDERKW KQQLQELSKL PAFARVVSAG NLLSHVGHTI
LGMNTVQLYM KVPGSRIPGH QEHNNFCAVN INIGPGDCEW FAVPEPYWGV MSNFCEKNNI
NFLMGSWWPN LEDLYEADVP VYRFIQRPGD LVWLNAGTVH WVQAIGWCNN IAWNVGPLTA
HQYKLAVERY EWNKLQSVKS MVPMVHLSWN MARNIKVSDH KLFEMIKYCL LRTLKQCQSV
KEALVSAGKE TALRPRTREE PAHYCTICEV EVFNLLFVRR ELLSKKQHVI HCLDCARKGS
ATLDDFVVLE QHRMEDLMQV YDQFSLAPPL HSSSS
//
