ID H3AKT2_LATCH Unreviewed; 4872 AA.
AC H3AKT2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|Ensembl:ENSLACP00000010253.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010253.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AFYH01122677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01122686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000010253; -.
DR Ensembl; ENSLACT00000010331.1; ENSLACP00000010253.1; ENSLACG00000009033.1.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000155281; -.
DR HOGENOM; CLU_000065_3_0_1; -.
DR InParanoid; H3AKT2; -.
DR OMA; MYCKHLE; -.
DR TreeFam; TF354317; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000009033; Expressed in chordate pharynx and 1 other cell type or tissue.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15697; ePHD2_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15600; PHD6_KMT2C; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041968; KMT2C_ePHD2.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR047005; KMT2C_PHD6.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 5.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00184; RING; 6.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 145..249
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 259..309
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 306..356
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 385..441
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 889..942
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 939..989
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1016..1071
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4360..4468
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4732..4848
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4856..4872
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1985..2319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2567..2710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2733..2925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3177..3205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3336..3378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3568..3789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3808..3843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3861..3884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3935..3979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3997..4017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4216..4235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2355..2382
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3205..3242
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1497
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1818..1841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1886..1914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2084..2139
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2583..2615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2626..2652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2657..2685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2686..2702
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2733..2771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2772..2798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2805..2827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2835..2849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2850..2925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3189..3205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3336..3355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3363..3378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3594..3677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3681..3702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3724..3741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3761..3781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3811..3825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3868..3882
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3954..3968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4872 AA; 538070 MW; 0F58ABF95B509860 CRC64;
EIKGQNAEEG DVQAEADISE QLTPVLQRTA SEESTGSTAS VGVEVKTSNE KLCALCYCGE
RSLLGQGELK QFDPTPGFTV PWKSQSKSKK GSNDRLGDKN PKQNSVSRRQ RGQKKDRGSR
NSTASCMNVS TQTTSDEQVS KCWDELSLVG IPDEIDMEAL FEPTGHCWTH HRCAEWSEGV
CQTEEMVLIN VDKAVVSGST EHCAYCKHLG ATIKCCEEKC NRLYHYPCAA GAGTFQDISR
LTLLCPEHIN LAPERSKDEA NCAVCDSPGD LLDQLFCTSC GQHYHGMCLE ISATPLMRAG
WQCPDCKVCQ TCKHSGDDSK MLVCDTCDKG YHTFCLQPVV DSVPTNGWKC KNCRVCVECS
TRISSQWHLN CSVCDNCYQQ QYPVSLSCPL CGKMYHLDTQ KDMLHCQLCK RWTHIDCNKL
TDNDMDSQLK EGYICTLCKQ TEGVVEQMTP CDVMETDELV QEPATGIDEV EIEDTEEMLT
QKQVAGWLRD VAGSVIVPGM GPDDIELGTK ETSKFHLFKR WTTYSQLIFF MSLHEQNEEP
ELTQQSDITE KEASQPEEME ISEQTHTEQA MEVMEEAEVD RDLVMEQQGE EQKVKEPDKA
PEAVQGESQC QTPAPKVETE ISATENIHQK QELSPLKEEP TESVATVEDS TDKKENEECQ
TSGSSVIMEM NTVPNLDSLS ETASPGEEKF SKTLPETAPV MKSEIESIRT PVSPSPFHSV
GTPSAGEVPR RYSSQIGTTF NSILPSTFVS MTPKIGMGKP AITKRKFSPG RPRVRQGGWT
ATNTVSLPSW PPDISEGRDY FKSRQPPSSA IWSIKVGRGS GFPGKRRPRG AGLSGRGGRG
RSKLKNGLGA MIMPGFSILD APSSKDEDEN TMRNTVVLFS SSDKFTLQQD MCVVCGSFGR
GAEGRLLACS QCGQCYHPYC VSIKITKVVL SKGWRCLECT VCEACGKATD PGRLLLCDDC
DISYHTYCLD PPLQTVPKGG WKCKWCVGCT HCGATSPGLR CEWQNNYTQC APCASLATCP
VCYLNYREEE LILQCRQCDR WIHASCQNLN TEEEVETAAD NGFDCSMCRP FVTPTHVPTL
DCCESPLVAQ IVTKLKEPGL DPPKTYTQDG VCLTETGRSQ LQSLTISVQR RKRPKPKLKL
KIINQNSVAV LQTPPDPQSE HSRDGDMDDS RGTIEEMLDS TPVIDSCPKT RNIELEAHNI
EFSYYIDKVQ RKTCNSGFEV SYPKYFVSKY KVELKGALIK RKCSHEIGEK FPCEDYLHFI
NSWSEQLPDT PVDETAPGSE STEKIKKRYR KKKNKLEETF PAYLQEAFFG KDLLDTSRQT
KLSLDSLPDE PTPLPSKTAN VNTNFLDPSS DPLLSSATTS VPVKQGAQAN SDDPLADLSE
VLNTEDDILG ILSDDLVKPV DDSAGLDIGP ISDDPAAAPQ PSGSQSSRPL SEEQLDGILS
PELDKMVTDG AILSKLYKIP ELEGKDVEEL FTAVLSPTSN QPPPPPPPPP PPPQPQMMMA
LHNNLGDGMF PRMPMMNGLM GPNPHLPANP LTPRGRHCIP GTFSLPQSSF PDNRDKNSTY
GPMVNDTNSP WTTPAPVTEG EGDTMSNAQR STLKWEKEEA LDEMATVAPV LYTNINHPNL
REDFPDWSTR VKQIAKLWRK ASSQERAPYV QKARDNRAAL RINKVQMSSD SLKRQQHQDS
MDPASRIETD LFKDPLKQKE SEHEQEWKFR QQMRQKNKQQ AKIEATQKLE QVKNEQQQQQ
QQQFGGQQLS GQTGGDTSNS GVQSPLPPQQ GNGNRSPAQQ MLPKDLFAKQ QLPGTPASLS
SEDVFVKPQP PPPTPTRISA QDQFAQTSQP QSPQVFSPGA ASSRPPSPFD PYAKMVGTPR
PPPIGQNFVK RNSLSPMDTC PPPPAMSRSL QGNEQSGSSR PSPARDSFGS PTHGNSDPYI
KPPDTPRPAM TTEPFAKPMG MQRPQLNIDQ SGRAPIATGD CDPFAKPALR PDVFQRQQMA
LNRLAPQDSY ARSSLPLTPT VNEGGTGTFK TPMRPPQSPQ DPYVSMPGTP RYMPVDPYER
HVLTPRPAET FSQNHLADPY TQPPLTPRPA ISEQFVHPQR MDPHAQPPGT PRPAPQDPYA
QPPGTPRPAP PDAYAQPPGT PRPALQDPYA QPPGTPRPAL QDPYTVDPYA QPPATPRSTM
GDRFVQSPVN QRHSDPYAQP PGTPRPINSS FTHPQQAAPR PGIPEYFNRS SMARPGFMPD
QQPFLQTRGP ALQDSFIRPA DPCSQPSQTP RLAGPTVTES FSHGSESSVC DSYDQHPMTP
RKQSGDTFGS GHLGNDTVEQ QGSGPGTEPS FCTPGSSPMN SHVQLFPTVP LATGPGTPVV
STETMSNTNL PQADTEEKLR QRQRLREMIL RAQQQKNAGR QEKGLQELPA PLAMGSHRHW
QREDLSRQNE FFSRPPPPYP GNIRTAGGSR FAVFSKDQRG PFPGDDMAAI GMRPHGSRFG
FPGSGQGPVP GQERFIGPPQ PMQGPGFPQQ LRRSLSVDLA RPVNNPQINN PVGLPQPFSP
QGLQVQQHNI LGQPFIELRH RVDSRPRLPF GSSVTPTNVM DLASQQQKPG GFLSVPVGQG
QRPMQPMGNQ QHGIVSQLQM ASSLQNLSQQ QHLMTAGHPP VPLMRSLSHQ PSSDTFSASS
STSTTSAPGD ISISNEEAGG LEEKLDPDDP AVKDLEDVKD LDSVEVKDLD DEDLENLNLD
TEDNLETNDP HLDDLLRSGK FDIIAYTDPE LDLGDKKDMF SEDLDLNDPI DDKLEVPCKR
DEEKKKSNES TVDPTKGLSP QKKANPGNEG TSESLRLISQ ADKLPEKSNS EESIGEGMDK
TELNSEAKDM LHSSNVQSSE EKRSEEAISN QETTEASPSL SQSSAQLPSQ NGPSSCSLTV
TPSVLSSLLT TEKSESSGLG SLDSSNQAMP PSQPMSMGSG PQASNVMIPS EQVSEHAVNP
NMPMGPRINR SFSHGASLNP GFIQGQAPGH NFGAGPSSNQ TMPLTNQPGP SGIAAPQQIM
LSQVINQQTR ERPLLLEEQP LLLQDLLDQE KQEQQQQRQM QAMIRQRSDP FFPNIDFDAI
TDPIMKAKMV ALKGINKVMA QSNMGMPSMV MNRFSLMSQQ MPGVQGGDGQ NFIQQGTAQD
GAMPPQMSRP NPPSFGPGFF SNQDDAQRKQ YEEWLQDTQQ LLHMQQKFLE EQIGAHRKSK
KALSAKQRTA KKAGREFPEE DAEQLKHVTE QQSMVQKQLE QIRKQQKEHA ELIEDYRIKQ
QQCAVAPQTM MAGVQVPPPM VAGGHPPPLN QQNFPVLPQQ LQQQPPHPGI IPGQPSPARM
PNVQAWQTTS AAPRHLGGTA PRMQPPVPQM PINTTSSTPA AVASATAQSN APPRVEFDDN
NPFSETFQER ERKERLREQQ ERQKIQLMHE VERQRALQQR MEMEQQQQHG MMGAQLNNRP
QMPYFNSDLP CDFMPPQRPL QPQQQQQLQQ QMGQVLPQQN VQQGFIGSTP STPFMQGGEQ
RPMGPAAFGP EVPAVSPGTA NFQPMKPATG NISGPGIAQT QSRPPFGSAS MPVVPQSIVE
GAHFSQEMPL PSNYPGSGQS LIQLYSEIIP EEKGKKKRNR KKKKDDDAES VKTPSTPHSD
ITAPTTPSVS DSSIPTVNVP NDFVHHQPEQ ESTEAPCSSA PNTSISQLPT ELERQLSNSN
EPQTLTRQSS AVSETDRSQA EAPAKLQDIK LEHTESSQCH EQAEPKVDSP CGVKVEEEKG
TPPHPAVSTQ SPAQGTAAPG SKTEPGTELL KQLLKSKNAP LSHQRSEESL RSEDEGSVDS
KVAEKQNQLE GMQSLGLRFL NILGCLPETH KGKSLTKERS KWSRNSPEEV TSPSSKFKKK
YQSNKKAMYS KNYQKYYLKL QNNLSNPPTP PASLPPTPPP VARQKMVNGF ATTEELAGKP
GVLGGHDVSK TLGSKQFQLP FRPEDDLLAR AMAQGPKTVD VPASLPTPPH NNQEELRGQD
HCDDRDTPDS FVPSSSPESV VGMEISRYPD LSLVKEEPPD PVPSPVIPIL PSSTGKGSEA
RQADIKMEAS SGAMFFGSHF MQPHNGPKPG LISVAITLTP SAAENISGVV AAMADLLRVR
IPNSYEVSDA PVALLASRKM NAGLESRPPM MLQGPVRIAG SSVLVQPNIS FSSANSSTVT
VKEHHRNVAR SPVPKHQWCC HCKVVILGSG VRKSNKDLPF LKPDSCESSD RVERDTVFCS
NNCFVLYSTT FQAKTSETKE SSSAQESLFK ETPPKSFHQY SNNTSTLDVH CLPQLQEKIS
PPSTPPIIFP PAAFETAKVE TKPDELKVTV KLKPRPRTVQ GGLDDARPGS KKWKGMKWKK
WNVQIVIPKG TFKHPCDNEI DELIKKLGTS LKPDPMPKDG RKCCFCHEEG DGLTDGPARL
LNLDLDLWVH LNCALWSTEV YETQAGALIN VELALRRGLQ MKCVFCQKMG ATSSCHRLRC
TNIYHFTCAI KAQCMFFKDK TMLCPIHRPK GSHEQELKYF AVFRRVYIQR DEVRQIASIV
QRGERDHTFR VGSLIFHAIG QLLPQQMQAF HSSIALFPVG YEASRLYWSM RYTNKRCHYL
CSIEEKDGFP EFVVRVIEQG HEDLVLTDTT PKGVWNKILE SIDCLRKDSA MLKLFPGYLR
GEDLFGLTVS AVTRIAESLP GVEACERYTF RYGRNPLMEL PLAINPSGSA RSEPKMSTHV
KRFVLRPHTL NSTSTSKSFQ STVTGELNAP YSKQFVHSKS SQYRKMKTEW KSNVYLARSR
IQGLGLYAAR DIEKHTMVIE YIGTIIRNEV ANRKEKLYES QNRGVYMFRI DNDHVIDATL
TGGPARYINH SCAPNCVAEA VTFEKGHKII ISSNRRIQKG EELCYDYKFD FEDDQHKIPC
HCGAVNCRKW MN
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