ID I3K3T9_ORENI Unreviewed; 638 AA.
AC I3K3T9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=ddx59 {ECO:0000313|Ensembl:ENSONIP00000015784.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015784.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015784.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX59 subfamily.
CC {ECO:0000256|ARBA:ARBA00009718}.
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DR RefSeq; XP_005454017.1; XM_005453960.3.
DR RefSeq; XP_005454018.1; XM_005453961.3.
DR AlphaFoldDB; I3K3T9; -.
DR STRING; 8128.ENSONIP00000015784; -.
DR Ensembl; ENSONIT00000015799.2; ENSONIP00000015784.2; ENSONIG00000012538.2.
DR GeneID; 100701019; -.
DR KEGG; onl:100701019; -.
DR CTD; 83479; -.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00940000158639; -.
DR HOGENOM; CLU_003041_1_5_1; -.
DR InParanoid; I3K3T9; -.
DR OMA; DESFCIR; -.
DR OrthoDB; 446604at2759; -.
DR TreeFam; TF330866; -.
DR Proteomes; UP000005207; Linkage group LG15.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.30.60.220; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR InterPro; IPR007529; Znf_HIT.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04438; zf-HIT; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 219..247
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 250..425
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 436..599
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 24..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 219..247
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 33..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..91
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70747 MW; F16CD6EEF1D68D51 CRC64;
MFLPRALKVK RPTQGSAQVV IKKSKVVQEE DSKSGSETPA QSEEACEDTQ TRDATTQAAA
ESLAPEDGHS SLSDDSDDDD DDDDDDEEEE EEPVKSFKKN QRWPEPGEPA CVMCGRYGEY
ICDATDNDVC SLECKASHLV QMGMGTGADA FMQKDQNRDE MTVQSQQPAA DPGRVVESEP
GYFYREDRFI SGLTEEQVQR IKQELGIETQ GRDVARPVVE FEHCSFPATL SGNLKKAGYD
TPTPVQMQMV PVGLTGRDVI ASADTGSGKT VAFLLPVVVR ALEKSAHSVG SPVALILTPT
RELAIQIERQ AKELVMGLPN MRTALLVGGM PLPPQLHRLK SSIKIVIATP GRLIEILKQK
ELKLDKVKIV VVDEVDTMLK MGFQQQVLEV LEQVPEEHQT LLASATIPTG TEELAARLVR
DPVRITIGEK NQPCANVRQI LLWVEEPSKK KKLFEILNDG KLYQPPVVVF VESKLGADLL
CEAVAKVTGL TAVAIHSDKS QWERNRILRG LLDGDFEVVI STGVLGRGLD LVNVRLVVNF
DMPNTMDEYV HQVGRAGRLG HRGTAITLLN NNNKRLFLEV VNRVKPTGSI LPPQLLNSPH
LHEQQRREKQ RNKKDHEDSL VTTNNLLDII KKHDRRKK
//
