ID J8Q6J0_SACAR Unreviewed; 1276 AA.
AC J8Q6J0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=SU7_0661 {ECO:0000313|EMBL:EJS44236.1};
OS Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=1160507 {ECO:0000313|EMBL:EJS44236.1, ECO:0000313|Proteomes:UP000006968};
RN [1] {ECO:0000313|EMBL:EJS44236.1, ECO:0000313|Proteomes:UP000006968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H-6 / AS 2.3317 / CBS 10644
RC {ECO:0000313|Proteomes:UP000006968};
RX PubMed=23368932; DOI=10.1186/1471-2164-14-69;
RA Liti G., Nguyen Ba A.N., Blythe M., Mueller C.A., Bergstroem A.,
RA Cubillos F.A., Dafhnis-Calas F., Khoshraftar S., Malla S., Mehta N.,
RA Siow C.C., Warringer J., Moses A.M., Louis E.J., Nieduszynski C.A.;
RT "High quality de novo sequencing and assembly of the Saccharomyces
RT arboricolus genome.";
RL BMC Genomics 14:69-69(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJS44236.1}.
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DR EMBL; ALIE01000042; EJS44236.1; -; Genomic_DNA.
DR AlphaFoldDB; J8Q6J0; -.
DR HOGENOM; CLU_001832_0_1_1; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000006968; Chromosome IV.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008186; F:ATP-dependent activity, acting on RNA; IEA:UniProt.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0022613; P:ribonucleoprotein complex biogenesis; IEA:UniProt.
DR GO; GO:0006396; P:RNA processing; IEA:UniProt.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006968}.
FT DOMAIN 410..589
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 684..866
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..304
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..728
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 146122 MW; 755847DE44576F01 CRC64;
MGTYRKRFNE KARSGHMAKL KELKKVRNKQ FTRQDENDEE IKQPDSDPSQ DNVPNSNVNA
EILEPLTEEE KKLKKRKLQE LFTPKESKVS RLKKKRLDKF IEHQLKREER KTIIDKLQDY
KIDTSLLTSS KKLGEGRQTK REEFKEALSL ERQGRGSKQV KEILYKEYEP KVWDKDSQTE
SHDDGEGDIE DDFEATFGGM AEPKEIGEED KKPSGFIDHR PAKFGGSGFG FGFSNVKVIN
KGKKTPKKKY NWRQLVAIEE QKRHGKDDEM DFDTSSEDGD EDSSEEQEEY EGEGQEECSE
NSSEEIEGEN DRTESDDTSQ KDIANKFKDW ANQEIKKMEG RDQDLVTPNL NIDYKPIVRK
EDLDDGLKEA YIPINENSTR KAFYVKVNRS HEIQKTRIQL PVFGEEHKIM EAIHHNDVVI
ICGETGSGKT TQVPQFLYES GFGAEASPDY PGMVGITQPR RVAAVSMAGR VANELGDHGH
KVAYQIRFDS TTKEDTKVKF MTDGVLLREM MHDFKLTKYS SIIIDEAHER NINTDILIGM
LSRCVRLRAK QHEENPVEHK ELKLIIMSAT LRVSDFSENK ALFPIAPPVL HVDARQFPVS
VHFNRRTAFN YTEEAFKKTC KIHQKLPPGA ILVFLTGQQE ITHMVKRLRK EFPFKKNSKY
NKELETPISK VGISSRTTNL EAEDIDFSVR IIDEDKFKST IEYEDEADNE KDGEEEEEEE
EGFEETLTEE QTANDPLYVL PLYSLLPTKE QMRVFQQPPP GSRLCIVATN VAETSLTIPG
VRYVVDSGRC KERKFNESNG VQSFEVGWVS KASSNQRSGR AGRTGPGHCY RLYSSAVFEH
DFEQFSKPEI LRMPVESIVL QMKSMAIHNI VNFPFPTPPD RTALAKAVQL LQYLGALDDK
EKISEDGKKM SLFPLSPRFS KMLLVSDEKA CVPYIVAIVS ILSVGDPFIN EFELGINETV
RKPKDDEDVD ENDRKKVDDS ISHMDSELKK ELRGKFYKSR AQFSKLDKYS DVFRLLSVVS
AMDYIPREQK EIFMKKNFLR GKLMEEIVKL RKQLMYIIQS NISKENVAVV IRNEDLKSDM
PSVIQIKLLK QMICSGFVDH VAVRADVLFP DDAKITNRTS MINIPYVPVM AMRTPNIEDC
FVYIHPTSIL NNLGEMPPKY MIYHSLHLGG NSKTRMNTLC DIASTPLANV ARKGLLLTYS
KPLTGQGLKT INLSPTERYC YVIPRFGSTV DNDLKIGWDL NPIAVYQQKQ NGQWTVIKFI
TKKSFQSATS EDKKKN
//
