ID M1D3A4_SOLTU Unreviewed; 848 AA.
AC M1D3A4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN Name=102578970 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080296};
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080296, ECO:0000313|Proteomes:UP000011115};
RN [1] {ECO:0000313|Proteomes:UP000011115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DM1-3 516 R44 {ECO:0000313|Proteomes:UP000011115};
RX PubMed=21743474; DOI=10.1038/nature10158;
RG The Potato Genome Sequencing Consortium;
RT "Genome sequence and analysis of the tuber crop potato.";
RL Nature 475:189-195(2011).
RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400080296}
RP IDENTIFICATION.
RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400080296};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC for the generation of small interfering RNAs (siRNAs).
CC {ECO:0000256|RuleBase:RU363098}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
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DR AlphaFoldDB; M1D3A4; -.
DR EnsemblPlants; PGSC0003DMT400080296; PGSC0003DMT400080296; PGSC0003DMG400031261.
DR Gramene; PGSC0003DMT400080296; PGSC0003DMT400080296; PGSC0003DMG400031261.
DR HOGENOM; CLU_001366_3_2_1; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; M1D3A4; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000011115};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ SEQUENCE 848 AA; 96096 MW; 7D7AB16EAF7F210F CRC64;
MGKTIQVYGF PDLLSAEVVK SFLEKHTGYG TVCALEVKQS KGGSRAFAKV QFVDNISADK
IINLASKRLY FGSSYLKARE METDLVQLWE YVDHMDGITL NFGCQISDDK FAVLGSTEVS
IKFGIGLKKF FFFLSSGSAD YKLQLSYENI WQVVLHRPYG QNAQFLLIQL FGAPRIYKRL
ENSCYSFFKE TPDDQWVRTT DFAPSWIGLS SSLCLQFRRG VHLPNFQESF FHYAERENNI
TLQTGFTFFV SQKSALVPNV QPPEGIAIPY KILFKISSLV QHGCIPGPAL NVYFFRLVDP
QRRNVACIEQ ALEKLYYLKE CCYDPVRWLT EQYDGYLKGR QPPKSPSINL DDGLVYVRRV
LVTPCKVYFC GPEVNVSNRV LRNYSEDIDN FLRVSFVDEE WEKLYSTDLL PKASTGNGIR
TNIYERILST LRKGFVIGDK KFEFLAFSSS QLRDNSVWMF ASRPGLTAID IRTWMGDFSQ
IKNVAKYAAR LGQSFGSSTE TLSVLRHEIE VIPDVKVHGT SYVFSDGIGK ISADFARRVA
SKCGLQHTPS AFQIRYGGYK GVVAVDPYSS MKLSLRKSMS KYESDNNKLD VLGWSKYQPC
YLNRQLVTLL STLGVKDDVL EQKQKEAVDQ LDAILHDSLK AQEALELMSP GENTNILKAM
LNCGYMPDAE PFLSMMLQTF RASKLLDLRT KSRIFIPNGR LMMGCLDESR TLEYGQVFVQ
FTGSGHREFS EDLHPFNNSR STNCNFILKG NVVVAKNPCL HPGDIRVLRA VDVPALHHMV
DCVVFPQKGK RPHPNECSGS DLDGDIYFVC WDQDMIPPRQ VQAMEYPPAP SIQLDHDVTI
EVPLVSNN
//