ID   M2SMX9_COCSN            Unreviewed;      1244 AA.
AC   M2SMX9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=COCSADRAFT_178332 {ECO:0000313|EMBL:EMD68523.1};
OS   Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS   spot blotch fungus) (Bipolaris sorokiniana).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD68523.1, ECO:0000313|Proteomes:UP000016934};
RN   [1] {ECO:0000313|EMBL:EMD68523.1, ECO:0000313|Proteomes:UP000016934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2] {ECO:0000313|Proteomes:UP000016934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA   Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA   Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA   LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA   Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector coding
RT   capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; KB445638; EMD68523.1; -; Genomic_DNA.
DR   RefSeq; XP_007696101.1; XM_007697911.1.
DR   AlphaFoldDB; M2SMX9; -.
DR   STRING; 665912.M2SMX9; -.
DR   GeneID; 19133134; -.
DR   KEGG; bsc:COCSADRAFT_178332; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   HOGENOM; CLU_001366_2_0_1; -.
DR   OMA; VDEKKIW; -.
DR   OrthoDB; 5477883at2759; -.
DR   Proteomes; UP000016934; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF17; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016934};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   1244 AA;  141108 MW;  605039A859B1ACCA CRC64;
     MDIYIPSVPK DANHVELQRF LKDKLLKLDI LAFDIRKHNT HKGRPFAILT VPSTSNGNRF
     LQYYGSRGRQ APLHSLVFQG QALTFCKNNK PGQPDPLKIR TLQEKDAAMR SKMGSQAPTA
     QASQADQSTL SFSALMTGVW DYTTLGTLSF QEKYKDKRQG YITFGKSSLV VYLQESTLES
     YNWHCRIDIP YAIIEHVVPS FGFENQGRNG AITFTLKSPP KFYSIESTDD LHLYAGKEAP
     QVQILLAGLA ALNLTSKQKT NRLERLCALN TKNTKNSALC MVYQIAFSDT WSAQHAWNFV
     KDHSVPEEYC WQNMIPNKGS HRIEDELVVV ESKLSAYNPS IPPAFNFAVR YQLAALVLEG
     TITPTAMINL IPHIHQIAKQ HGAETTAIAV RRLGQQVPTP APVISAEMFK VRKFVELVQE
     NVEDCKHWGL AYRDLNGKQK KHHHLALTYK ATVTPTGILL RGPDWDVSNR VLRRYTTRTE
     YFMRVFFADE DGLSVFHDSR ASQNQVYERF RNVLQNGISV AGRTFQFLGF SHASLRNHQA
     WFMAPFEMDG SLVRARNVIQ DLGDFSHIHC SAKCAARIGQ AFSDTIFSVP VPETAYVTEV
     KDDVERNGRT FSDGCGTISL ELLRTVWRAL PPERRQQRPT VLQIRYRGAK GVLSLDASLS
     GQQLHVRKSM TKYIAKETWR DLELCGAAYK PLSVFLNHQF IKILEDLGVP AEKFLDVQDE
     AVKILKLITE HPLNAASFLA YSHSCVFAKV PQLFEMMHRI GLSFHADRFL TDIVEVAAMS
     SLRSLKYRAR IPIEKGYLLY GVMDETNTLK YGEVYIATED HDKTGKLKRS ILVGNQIVVT
     RAPALHPGDV QLVNAVDVPD DSPLRALHNC VVFSQQGPRD LPSQLSGGDL DGDLFHIIYD
     QRLIPAYTVE PAEYDKVPAN DLGRPVEAND IVDFFIEYMK MDRLGQISNK HKIRADVKPN
     GTRHPDCLIL AKLASDAVDF SKTGVPADMS LIPKGIDHFR PDFMAPGSNL VINELGAAEL
     AGIEEDDIDD PDSISVLDAD KGRIRYYRSD KILGILYRAI DEKKFFDKMK SDYEIFRQRW
     GKESLVNKLK RYIIRETQGL QWEHHWDFAE QLRETYEDNM LEIMDTLRPT RGAPLTELEV
     FSGNILGKKE RASSRYIREA NLEVQERFNR DVSSMIKTIV HGDKDWDSEE DATEALPRSI
     ACFMVALEVK GWENYRSLQS WKYVAASVCL EQLWKYNGGT LRCL
//