ID M5E478_MALS4 Unreviewed; 750 AA.
AC M5E478;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=MSYG_1520 {ECO:0000313|EMBL:SHO77179.1};
OS Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=1230383 {ECO:0000313|EMBL:SHO77179.1, ECO:0000313|Proteomes:UP000186303};
RN [1] {ECO:0000313|Proteomes:UP000186303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000186303};
RX PubMed=28100699; DOI=10.1093/nar/gkx006;
RA Zhu Y., Engstroem P.G., Tellgren-Roth C., Baudo C.D., Kennell J.C., Sun S.,
RA Billmyre R.B., Schroeder M.S., Andersson A., Holm T., Sigurgeirsson B.,
RA Wu G., Sankaranarayanan S.R., Siddharthan R., Sanyal K., Lundeberg J.,
RA Nystedt B., Boekhout T., Dawson T.L. Jr., Heitman J., Scheynius A.,
RA Lehtioe J.;
RT "Proteogenomics produces comprehensive and highly accurate protein-coding
RT gene annotation in a complete genome assembly of Malassezia sympodialis.";
RL Nucleic Acids Res. 45:2629-2643(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; LT671822; SHO77179.1; -; Genomic_DNA.
DR RefSeq; XP_018738789.1; XM_018883520.1.
DR STRING; 1230383.M5E478; -.
DR GeneID; 30055029; -.
DR KEGG; msym:MSY001_0144; -.
DR VEuPathDB; FungiDB:MSYG_1520; -.
DR HOGENOM; CLU_001832_5_11_1; -.
DR OMA; KVKVWRH; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000186303; Chromosome 2.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:SHO77179.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186303}.
SQ SEQUENCE 750 AA; 82220 MW; CCA9DAAFC1B2210A CRC64;
MSPAMDAKDA LPVWAGKEKI VQRIRENDTV ILVGETGSGK TTQVPQFLLQ EGILPSEGQQ
MIGITQPRRV AATSLARRVA AELGCADPAT LKEKQDHTGA GLPEWVGYSV RFDDRTTRHT
RIKFLTDGML IREILGPSPR RRSKSTERAM KETNDYALKR YSVLIIDEAH ERSIRTDMVL
GLAKRIQRDR RTRIAAGEPN VYPLKIVLMS ATIDAERFAQ FFSHGQPVPI LYVAGRQHGV
RLYHTEASCQ DWTDAAVRTV MQIHVSKPLG DILLFATGQE EIEAMAQSLK HYAAQLDAWA
DEHGQESVPA LIVRPLYAAL GPSASAAVFA PTPKDTRKVV LATNIAETSV TIPGVRYVVD
SGLVKEKVYS PQTHVETLQV LPVSQSSSLQ RAGRAGREGP GECYRLYTRE AFQELQPQPT
SEIHRTELSG AVLQLYAMSL DPFTFDWIEP PATSLLHEAV LQLAELGAVD SRKDEVQLTP
LGYRLAALPV TPSYARLLLA AAERGPHVAS QARDLVSILS ADRGLFVDVS DPEKREALEN
ARDQFVDTSG DHATMLNALR AYLLAQQHAF QSHPTPAAAR QELKLWCQTH AIHERTVKNV
LAIRKQLTRI CAQHGIECAD GGGGKGLAGH PDDGDSESDD DALIVTRHGV SSAKDSEQNY
ADLLQCLGMG RLSHVALRQP DGSFRRIAGG QSFKLHPTCV LHPSRHGARG VSSDSVQAIV
FEELVMTSQT FARTVSKLEP AWLQALLAAS
//
