ID N9Y6K8_9CLOT Unreviewed; 495 AA.
AC N9Y6K8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=NAD(+) hydrolase ThsA {ECO:0000256|ARBA:ARBA00035033};
DE EC=3.2.2.5 {ECO:0000256|ARBA:ARBA00034327};
GN ORFNames=HMPREF1092_00624 {ECO:0000313|EMBL:ENZ03437.1};
OS Clostridium thermobutyricum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ03437.1, ECO:0000313|Proteomes:UP000013097};
RN [1] {ECO:0000313|EMBL:ENZ03437.1, ECO:0000313|Proteomes:UP000013097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=209318 {ECO:0000313|EMBL:ENZ03437.1,
RC ECO:0000313|Proteomes:UP000013097};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium colicanis 209318.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00034990};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00034990};
CC -!- SIMILARITY: Belongs to the soluble Thoeris ThsA family.
CC {ECO:0000256|ARBA:ARBA00035014}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENZ03437.1}.
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DR EMBL; AGYT01000007; ENZ03437.1; -; Genomic_DNA.
DR RefSeq; WP_002597127.1; NZ_KB850956.1.
DR AlphaFoldDB; N9Y6K8; -.
DR PATRIC; fig|999411.4.peg.602; -.
DR eggNOG; COG0846; Bacteria.
DR HOGENOM; CLU_028011_0_0_9; -.
DR Proteomes; UP000013097; Unassembled WGS sequence.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01406; SIR2-like; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR039444; SIR2-like.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR InterPro; IPR041486; ThsA_STALD.
DR Pfam; PF13289; SIR2_2; 1.
DR Pfam; PF18185; STALD; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000013097}.
FT DOMAIN 1..291
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
SQ SEQUENCE 495 AA; 56914 MW; 3E3680D575ECD941 CRC64;
MKFKREVYAF IEDYIEQLKQ GSAAIFAGAG LSAGVGFVDW KGLLEKPARR IGLDVQKEDD
LVTLAQYIFN EDGSRQPLTE VIRNNFISSN KINENHKILS LLPIKTYWTT NYDSLIEDSL
IKYGKNPDVK KTLADLSTII SMRDAVIYKM HGDINDANNA VLIKDDYEVY ETKNHLFTLN
LKADLISKTF LFIGFSFEDP NLEYILSKVR ILLEGNGRKH YCFLKKVNIK DFEKCQNPDE
EFKYAELKQR LKCADLKRYC IHPVLVDEYE DITEILRYID RMYRRNNVLI SGSADEFENF
NIKLKGKDEM IQPLDFIHDL CREISKSGFK IVTGYGKGIG SAVINGVLEN VYQTNTRNLD
DHMIIRPFPL YATKNITDEE FNLVRESYRK SLVEQAGITI FVLGNKIVNG EVVVADGVLK
EFEESLLIGS KVIPIGLTGY ASKELWEKVN TNFEKYYSEH RNLKAYFEVL GDENSNNEDI
INSVCSIIKD LREVF
//