ID Q5KEX1_CRYNJ Unreviewed; 783 AA.
AC Q5KEX1; Q55R99;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN OrderedLocusNames=CNF03920 {ECO:0000313|EMBL:AAW44045.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44045.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44045.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AE017346; AAW44045.1; -; Genomic_DNA.
DR RefSeq; XP_571352.1; XM_571352.1.
DR AlphaFoldDB; Q5KEX1; -.
DR STRING; 214684.Q5KEX1; -.
DR PaxDb; 214684-Q5KEX1; -.
DR EnsemblFungi; AAW44045; AAW44045; CNF03920.
DR GeneID; 3258437; -.
DR KEGG; cne:CNF03920; -.
DR VEuPathDB; FungiDB:CNF03920; -.
DR eggNOG; KOG0925; Eukaryota.
DR HOGENOM; CLU_001832_5_11_1; -.
DR InParanoid; Q5KEX1; -.
DR OMA; MKVYPLY; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000002149; Chromosome 6.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 107..273
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 301..485
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 88340 MW; FB1EC1F0719A03D1 CRC64;
MSEPPAKRSK MDSTAASENN PYLAHRNEGP SYGGMTNGAN GVTGSIDRNE HPLNGMVPRK
VTVDQAKKIM DGDVNPFKNL APWSNTYKRI LEQRKGLPVY QKMQEFLTVF NENQIVVMEG
QTGSGKTTQI PQFVCYSDLP MLRGKMVACT QPRRVAAMSV AKRVADEMDV QLGKQVGYSI
RFEDMTEPGT TFLKYMTDGM LLREAMNDPL LERYSTVILD EAHERTLATD ILMGLLKDIA
KRRSDLKIIV MSATLDVAKF QKYFGDTNPT GLAPVVKVSG RTFPVETFFT QEPENDYVEA
AIRTVLFIHQ AEDEGDVLLF LTGEEEIEDA CRKIRAEGEE LANKGMAGPL LVVPLYSSLP
PHQQQRIFDP APPARKDGLP GRKVVVSTNI AETSLTIDGI VYVVDPGFCK QKVYNPRIRV
ESLLVTPISK ASAMQRAGRA GRTRPGKCFR LYTERDFVKE LEEQTHPEIL RSNLANTVLE
LIKLGIKDLV HFDYMDAPAP ETIMRALELL HYLAALDDDG NLTPLGSIMA EFPLDPQLAK
MLIVSPEFGC SNEILSLTAM LSVPNVFMRP ASQRKEADLA KAQFTHPDGD HLTMLNVYHA
YKSNEDDAKS WCWQNYLNQR SLAQADNVRT QLKRAMEKFD LELCSTAWED RNYWNNIRQA
LTCGFFMHVA HKEGEKGSYM TVKDNQVVRL HLSCGLDTTP EWVIYNEFVL TTANFIRTVT
EVRPEWLLEY APQYFDPETF PANSETRRAL QRVLDRKLGK ISSSKHGKDG KDKKDKKKKR
KAE
//